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141.
目的分析一腓骨肌萎缩症家系的临床表现及不同基因检测方法的特点。方法收集一CMT家系8名成员临床资料,并应用等位基因特异性PCR-双酶切方法及多重连接依赖的探针扩增技术(MLPA)检测PMP22基因突变情况,同时选择60名性别、年龄无明显差异的健康人做为对照组。结果该家系中患病者以行走不稳、跨阈步态,伴有弓形足为主要临床表现。该家系中5名成员经等位基因特异性PCR-双酶切及MLPA方法均检测出PMP22基因重复序列,其中出现临床症状的有4名(Ⅱ3、Ⅱ9、Ⅱ11、Ⅲ7),未出现临床症状但基因检测结果示PMP22基因重复序列的为携带者有1名(Ⅲ5),家系中余3名成员及对照组60名均未见重复序列。结论基因检测在明确CMT诊断中起重要作用,且MLPA法筛查基因时操作更简便、灵敏度更高、特异性更好。 相似文献
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143.
Tinghu Kang Yang Li Jiandong Guo Xingwen Ma Fatema Akhter Hiramoni Md Zahir Ahmed Mary C. Jobe Oli Ahmed 《International Journal of Mental Health Promotion, The》2022,24(2):207-217
The aim of the study was to explore the relationship between college graduates’ dual self-consciousness, job search
clarity and perceived stress, and reveal the mediating role of perceived stress between dual self-consciousness and
job search clarity. In this study, 467 college graduates were investigated using the Dual Self-Consciousness Scale,
Job Search Clarity Scale, and Perceived Stress Scale. After controlling for gender, age, and region, the results
revealed that: (1) private self-consciousness has a significant positive predictive effect on job search clarity; (2)
perceived stress has a significant negative predictive effect on job search clarity; (3) perceived stress plays partial
mediation effects between private self-consciousness and job search clarity; (4) perceived stress plays complete
mediation effects between public self-consciousness and job search clarity; (5) perceived stress has suppressing
effects between public self-consciousness and job search clarity. 相似文献
144.
145.
手术患者“边缘时间”的安全护理 总被引:7,自引:0,他引:7
现代医院手术室每日接待大量的手术患者,虽然都已经认识到各种风险的存在,但往往把目光集中在手术间内,而容易忽略手术前、后病人在转运过程“边缘时间”的安全。文章总结、分析了以往手术前后“边缘时间”存在的风险,设置了合理的接送程序;使用患者身份识别腕带的“五查对制度”;采取搬运患者前的“一查、二看、三整理、四搬运”等护理对策。 相似文献
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149.
血管生长因子在血管新生过程中起着重要作用.大量的动物研究显示在给予血管生长因子后能够有效地促进缺血心肌的血管新生,改善局部血流灌注,提高心功能.但由于临床Ⅱ期试验未取得预期的阳性结果,给治疗性血管新生的应用带来了新的挑战,众多问题有待进一步优化和解决. 相似文献
150.
Thomas S. Klitzner Maggie Lee Sandra Rodriguez Ruey‐Kang R. Chang 《Congenital heart disease》2006,1(3):77-88
Background. It has been reported that gender differences in cardiovascular outcomes found in adults also are present in children who undergo surgical repair for congenital heart disease. Methods. California statewide hospital discharge data 1989–99 were used to study outcomes in children <18 years undergoing cardiac surgery. Hospital discharge data were linked to death registry data to study postdischarge death within 30 days of discharge. We used logistic regression to evaluate the effect of gender on mortality controlling for age, race and ethnicity, type of insurance, household income, date and month of surgery, type of admission, hospital case volume, and various types of procedures. Results. There were 25 402 cardiac surgery cases with 1505 in‐hospital deaths (mortality rate of 5.92%). An additional 37 deaths occurred within 30 days after hospital discharge. Crude mortality rates for males (5.99%) and females (5.84%) were not significantly different. However, fewer neonates were female and females underwent a higher proportion of low‐risk procedures than males. Logistic regression revealed that females, compared with males, had a significantly higher odds ratio (OR) for in‐hospital mortality (OR = 1.18, P < .01) and overall (up to 30 days post discharge) mortality (OR = 1.18, P < .01). The risk‐adjusted length of hospital stay was similar between females and males while charges per hospital day were slightly higher in females than males. The prevalence of Down syndrome, pulmonary hypertension, and failure to thrive were higher in females. Conclusions. Female gender is associated with an 18% higher in‐hospital and 30‐day postdischarge mortality as compared with male gender. There was no difference in length of hospital stay between males and females. The mechanism by which female gender acts as a risk factor requires further investigation. 相似文献