右旋布洛芬注射液安全药理学研究

目的 评价右旋布洛芬注射液对动物中枢神经系统、心血管系统及呼吸系统的影响。方法 通过小鼠自主活动试验、运动协调试验和戊巴比妥钠催眠/睡眠试验,考察右旋布洛芬注射液对中枢神经系统的影响;通过对清醒Beagle犬遥测心电图、血压和呼吸指标的检测,考察右旋布洛芬注射液对心血管系统和呼吸系统的影响。结果 右旋布洛芬注射液20、40、80 mg/kg剂量时对小鼠自主活动、爬杆行为均无显著影响,剂量为80 mg/kg时与戊巴比妥钠诱导的小鼠催眠/睡眠具有协同作用;剂量为10、20、40 mg/kg时对Beagle犬中枢神经系统、心血管系统和呼吸系统均没有显著影响。相同剂量条件下,右旋布洛芬注射液与布洛芬注射液比较,不良反应未见增加。结论 右旋布洛芬注射液对自主活动、运动协调能力、心血管系统和呼吸系统没有显著影响,大剂量时与戊巴比妥钠诱导小鼠催眠/睡眠有协同作用。     

风湿马钱片联合甲氨蝶呤治疗类风湿关节炎的临床研究

目的探讨风湿马钱片联合甲氨蝶呤治疗类风湿关节炎的临床疗效。方法选取2016年1月—2016年8月在南阳医学高等专科学校第一附属医院诊治的类风湿关节炎患者84例,根据治疗方案的不同分为对照组(42例)和治疗组(42例)。对照组患者口服甲氨蝶呤片,10 mg/次,1次/周。治疗组在对照组的基础上口服风湿马钱片,4片/次,1次/d,1周为1个疗程,两个疗程间隔3 d。两组患者均治疗12周。评价两组患者临床疗效,同时比较治疗前后两组患者临床症状评分和血清学指标改善情况。结果治疗后,对照组和治疗组总有效率分别为71.43%和90.48%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者关节疼痛、关节肿胀和晨僵等评分均显著下降,同组比较差异具有统计学意义(P0.05);且治疗组患者下降比对照组更明显,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血清C反应蛋白(CRP)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、环氧化酶-2(COX-2)、肿瘤坏死因子样配体1A(TL1A)和血沉(ESR)水平均明显降低,同组比较差异具有统计学意义(P0.05);且治疗组患者上述血清学指标显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论风湿马钱片联合甲氨蝶呤治疗类风湿关节炎可有效改善患者临床症状及血清细胞因子水平,具有一定的临床推广应用价值。     

Achievement of safer palladium nanocrystals by enlargement of {100} crystallographic facets

Developing catalytic and safe nanomaterials is very necessary for the reduction of potential risk to human health; however, this strategy has been found extremely challenging because the enhancement in catalytic activity of nanomaterials is inevitably accompanied with more potent cell injury. The relationship of physicochemical properties and biological responses in catalytic nanomaterials needs to be clarified at the nano–bio interface for achieving the safe application. Herein, high-energy crystallographic facets of palladium (Pd) nanocrystals that have been known to significantly contribute to the catalytic activity were introduced to attenuate the toxicity, and the underlying mechanism was unraveled. Polyhedral Pd nanocrystals with morphology evolution from truncated octahedron to cuboctahedron and cube were prepared for elaborately tuning the extents of high-energy {100} facets, and hierarchical in vitro and in vivo biological evaluation were performed to clarify that Pd nanocrystals exposed with the more {100} facets could show the less toxicity to cells and animals. Density functional theory (DFT) calculation revealed {100} facet exposure was endowed with a strong oxygen adsorption, which weakens the breakage of the water molecule and suppresses the hazardous water dissociation and hydroxyl radical generation, which was supported by electron spin resonance (ESR)–based radical evaluation and X-ray photoelectron spectroscopy (XPS)-based oxygen identification. This means high-energy facet-based catalytic Pd nanocrystals can deliver low toxicity due to their unique surface properties.     

半夏曲炮制中4种优势微生物的生理生化特性及黄色素含量测定

目的研究半夏曲中4种优势微生物的生理生化特性,测定炮制过程中不同时间点各样本的黄色素含量,为揭示半夏曲炮制机制奠定基础。方法以半夏曲中筛选出的4株优势菌枯草芽孢杆菌Bacillussubtilis、宛氏拟青霉Paecilomyces variotii、丝衣霉菌Byssochlamys spectabilis、黑曲霉Aspergillus niger为研究对象,分别测定它们的最适宜生长温度、pH值,利用糖类的产酸能力以及产淀粉酶、蛋白酶、黄色素的能力,同时测定半夏曲炮制过程中5个不同时间点样本的黄色素含量。结果枯草芽孢杆菌、宛氏拟青霉、丝衣霉菌、黑曲霉生长的最适温度分别为35℃、29℃、29～31℃、39℃,最适pH值分别为7.0、7.0、7.5、7.0。4种菌均具有产淀粉酶和蛋白酶的能力,宛氏拟青霉、丝衣霉菌具有产黄色素能力。5个不同时间点样品的黄色素质量分数分别为69.875、69.875、71.750、119.500、137.875μg/g。结论 4种优势微生物在半夏曲炮制中可能起重要作用。     

Brief Report: Specificity of Interpersonal Synchrony Deficits to Autism Spectrum Disorder and Its Potential for Digitally Assisted Diagnostics

Journal of Autism and Developmental Disorders - Reliably diagnosing autism spectrum disorders (ASD) in adulthood poses a challenge to clinicians due to the absence of specific diagnostic markers....     

Anti-HMGCR myopathy overlaps with dermatomyositis-like rash: a distinct subtype of idiopathic inflammatory myopathy

Journal of Neurology - To characterize the clinical and pathological features of anti-HMGCR myopathy. The presence of anti-HMGCR antibody in the serum of 227 patients with idiopathic inflammatory...     

Conversational metrics,psychopathological dimensions and self-disturbances in patients with schizophrenia

European Archives of Psychiatry and Clinical Neuroscience - Difficulties in interpersonal communication, including conversational skill impairments, are core features of schizophrenia. However,...