The influence of carcinoma growth on diamine oxidase activity in human gastrointestinal tract

The distribution of diamine oxidase (DAO) activity was studied in patients having no carcinoma disease. Besides in gut DAO occurred in high activity only in kidney and mesenteric lymph nodes.In patients with adenocarcinoma of the large bowel or of the stomach the enzymic activity was reduced in the tumour tissue itself as compared with the adjacent mucosa in which part the highest activities were observed. In stomach it seemed most important that the enzymic activity was enhanced in the whole mucosa, also in a 10 cm distance from tumour where no histological alterations were found. This fact should be checked for significance in early tumour diagnosis.Supported by A. v. Humboldt Stiftung.Supported by a grant from Deutsche Forschungsgemeinschaft (Lo 199/7).     

Comparison of immunofluorescence with enzyme immunoassay for detection of Q fever

To evaluate enzyme immunoassay (EIA) as an alternative to indirect immunofluorescence assay (IFA) to screen for Q fever in humans, 157 serum samples from patients suspected of having the disease were tested for immunoglobulin G antibodies toCoxiella burnetii. The agreement between the tests and the sensitivity of EIA were excellent (96.8% and 98.4%, respectively) when an IFAtiter of > 1/160 was considered positive. All serum samples with a titer of > 1/320 in the IFA were also positive by the EIA. The EIA seems to be an acceptable alternative to IFA for screening for Q fever.     

Antibiotics from Algae XXXIII1: Phlorotannins of the Brown Alga Himanthalia elongata2,3

It is possible to obtain approximately 0.2% (relative to dry weight) phenols soluble in ethyl acetate from HIMANTHALIA ELONGATA. After removal of a fraction containing high-molecular weight substances, a total of 17 oligomeric phlorotannins with 2 to 8 aromatic rings can be isolated from the mixture of the acetylated phenol fraction. Apart from 2 derivatives belonging to the fucol group, diphlorethol and a tetraphlorethol not yet fully identified, all the other substances are fucophlorethols. Amongst these substances, a phenoxylated therphenyl derivative and several fucophlorethols with two-fold phenoxy-substituted biphenyl moieties were identified for the first time.     

Untersuchungen zum Synergismus von Ciprofloxacin mit β-Laktam-Antibiotika,Gentamicin, Minozyklin und Pipemidsäure

Zusammenfassung In der Studie wurde untersucht, inwieweit durch Zugabe von Ciprofloxacin die antibakterielle Wirkung der Pipemidsäure sowie von Minozyklin, Gentamicin, Cefazolin, Mezlocillin oder Ampicillin gegenüber resistenten bzw. mäßig empfindlichen Testkeimen der SpeziesEscherichia coli, Klebsiella pneumoniae/Klebsiella oxytoca, Pseudomonas aeruginosa undStaphylococcus aureus beeinflußt wird. Die Untersuchungen ergaben eine synergistische Wirkung mit Pipemidsäure bei allen geprüften Spezies. Die Kombination mit Gentamicin ließ beiE. coli undK. pneumoniae/K. oxytoca Synergismus, beiP. aeruginosa undS. aureus additive Wirkung erkennen. Auch Minozyklin hatte mit Ciprofloxacin eine synergistische Wirkung, jedoch nur beiS. aureus. Bei den anderen Spezies und Antibiotikakombinationen war weder ein Synergismus noch ein Antagonismus festzustellen.

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Studies on the synergism of ciprofloxacin with -lactam antibiotics, gentamicin, minocycline and pipemidic acid

Summary UsingEscherichia coli, Klebsiella pneumoniae/Klebsiella oxytoca, Pseudomonas aeruginosa andStaphylococcus aureus strains, we examined a possible influence of pipemidic acid, minocycline, gentamicin, cefazolin, mezlocillin and ampicillin on the antibiotic activity of ciprofloxacin. We found in all bacterial species synergistic influence by pipemidic acid. When ciprofloxacin was combined with gentamicin, synergism was observed inE. coli and inK. pneumoniae/oxytoca, additive effects inP. aeruginosa andS. aureus. In combination with minocycline we demonstrated synergism inS. aureus only. In all other bacterial species and antibiotic combinations we found neither synergism nor antagonism.

     

Wissenstranslation am Beispiel Bewegungsförderung von älteren Menschen: Wie gelangen wissenschaftliche Erkenntnisse in die kommunale Praxis?

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Wissenschaftliche Ergebnisse können eine Wissensquelle für kommunale Akteurinnen und Akteure der...     

Aufbau von Interventionsdatenbanken für mehr Evidenzbasierung in Prävention und Gesundheitsförderung – methodische Überlegungen

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Kommunale AkteurInnen erfahren bei der Entwicklung und Auswahl von Maßnahmen der Prävention und...     

Sexualisierte Gewalt in der Erfahrung Jugendlicher: Ergebnisse einer repräsentativen Befragung

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Seit 1998 erhebt die Bundeszentrale für gesundheitliche Aufklärung (BZgA) im Rahmen ihrer Repräsentativbefragung...     

FAM19A4基因启动子甲基化检测在宫颈癌及其癌前病变筛查的研究

宫颈癌是最常见的妇科恶性肿瘤之一。目前人乳头瘤病毒(HPV)检测及细胞学检查是宫颈癌及其癌前病变(CCPL)的主要筛查手段。由于上述传统筛查方法,仍然存在对CCPL漏诊的风险,因此寻找有效识别CCPL的特异性分子标志物,具有重要临床意义。对具有序列相似性家族19成员A4(FAM19A4)基因启动子甲基化定量检测,可有效检出CCPL组织,较传统筛查方法有较高特异度,有望成为CCPL筛查的特异性分子标志物。笔者拟就FAM19A4基因启动子甲基化定量检测,在CCPL筛查中应用的最新研究现状进行阐述,旨在为进一步推进CCPL筛查方法的开发,提供思路。     

右颌下血管周肌细胞瘤一例

患者女,48岁。因发现右颌下结节1年余,长大2个月,于2003年11月10日入院。患者入院前1年无明显诱因出现右颌下结节,约豌豆大小,不痛,未予处理。2个月前发现结节进行性长大。体检：右颌下扪及一直径2cm类圆形肿块,固定,表面光滑,边界尚清,无压痛,未扪及血管搏动。     

Zur Anwendung des Rektaltemperatur-Todeszeit-Nomogramms am leichenfundort

Summary The application of the rectal temperature time of death nomogram at the scene of death by 11 authors from 6 lego-medical institutes resulted in a standard deviation of the differences between nomographic and real death time of ± 1.3 h in 46 cases (group I) with met requirements and clearly defined points of contact, nevertheless, including 9 cases with a more progressive cooling (0.5 > Q 0.2). In cases with a real death time of more than 4 h (N = 26) the standard deviation was ± 1.0 hours corresponding to permissible variation of 95% of ± 2.0 hours. Consequently, the permissible variation of 95% was much smaller than that suggested by the nomogram. The nomographic death time interval did not agree with the real one in 5 cases out of additional 30 cases with recognizably unsure points of contact (group II).