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71.
Squamous cell carcinoma in situ (Bowen's disease) is a common skin condition but has only rarely been described on the nipple. All reported cases have been treated with wide local excision and observation. A new treatment for Bowen's disease is photodynamic therapy. This has been reported as being able to treat Bowen's disease in other sites effectively with an acceptable local recurrence rate. We describe two patients presenting with itching and scaling of the nipple which were histologically proven Bowen's disease, one of these patients was treated successfully with a combination of photodynamic therapy and cryotherapy: this is the first time such a lesion has been treated in this way. 相似文献
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73.
Mechanism for the loss of preferential benzo[a]pyrene binding to the linker DNA of chromatin 总被引:1,自引:0,他引:1
We have examined the fate of the asymmetric chromosomal distributionof DNA adducts generated by the chemical carcinogen r-7, t-8-dihydroxy-t-9,10-oxy-7, 8, 9, 10-tetrahydrobenzo[a]pyrene (BPDE). Treatmentof mouse embryo cells with BPDE results in 3.5 times more bindingto the linker DNA regions between nucleosome cores than to thenucleosome core DNA itself, but 24 h post-treatment incubationof these cells leads to a loss of this non-random binding. Asimilar result was obtained when post-treatment incubation wascarried out in the presence of hydroxyurea indicating that factorsother than DNA replication are responsible for this change inadduct distribution. However in the case of excision repairdeficient xeroderma pigmentosum (XP12/BE) cells the non-randomadduct distribution was stable over a period of 48 h, whereaswith excision repair proficient XP variant (XP4/BE) cells, lossof preferential binding did occur. These results indicate thatthe loss of non-random nucleosomal DNA modification with timecan be accounted for by the preferential removal of adductsfrom micrococcal nuclease sensitive linker DNA and further,demonstrates that in certain cells at least, the relative positionof nucleosome core structures on DNA remains unchanged overa period of at least 48 h. 相似文献
74.
75.
Tarsal navicular stress fractures: radiographic evaluation 总被引:3,自引:0,他引:3
Tarsal navicular stress fractures are a potential source of disabling foot pain in physically active individuals. The diagnosis of tarsal navicular stress fracture requires a high index of clinical and radiographic suspicion because the fracture is only rarely evident on routine radiographs or standard tomograms. The radiographic diagnosis of a tarsal navicular stress fracture may require anatomic anteroposterior tomograms or a radionuclide bone scan with plantar views. Radiographic examinations of 23 fractures in 21 patients are evaluated. 相似文献
76.
Brookes CE 《The journal of the American Academy of Psychoanalysis and Dynamic Psychiatry》2005,33(2):275-285
In two previous articles by this author, the concept of psyche was given legitimate scientific status insofar as a necessarily new and unique scientific paradigm for psychodynamics was elaborated, stemming from the idea that positivistic science is not appropriate to the subjective data of psychoanalysis. This paradigm includes the idea that the concept of meaning as scientific validation is central to psychodynamic science. The concepts of erroneous meaning, synchronicity, and numinosity were introduced as aspects of this new scientific paradigm. In the present article, the complementary relationship between psychodynamic and traditional science is explored. The concepts of synchronicity, numiosity, and meaning are elaborated, together with discussion of the phenomenon of anxiety as it impinges on these dynamics. The concept of erroneous meaning is in this article separated from the concept of meaning itself through the idea that the activation of anxiety separates the two. 相似文献
77.
Gu HF Abulaiti A Ostenson CG Humphreys K Wahlestedt C Brookes AJ Efendic S 《Diabetes》2004,53(Z1):S31-S35
Adiponectin (APM1) is an adipocyte-derived peptide. The APM1 gene is located on chromosome 3q27 and linked to type 2 diabetes. In patients with type 2 diabetes, the adiponectin level in plasma is decreased in comparison to healthy subjects. To identify genetic defects of the APM1 gene that contribute to the development of type 2 diabetes, we genotyped 13 single nucleotide polymorphisms (SNPs) in 106 patients with type 2 diabetes, 325 patients with impaired glucose tolerance (IGT), and 497 nondiabetic control subjects in Swedish Caucasians by using dynamic allele-specific hybridization (DASH). We found that SNPs -11426(A/G) and -11377(G/C) in the proximal promoter region had significant differences of allele frequencies between type 2 diabetic patients and nondiabetic control subjects (P = 0.02 and P = 0.04, respectively). SNP-11426(A/G) was significantly associated with fasting plasma glucose in type 2 diabetic patients (P = 0.02) and in IGT subjects (P = 0.04), while the patients carrying CC and CG genotypes for SNP-11377(G/C) had a higher BMI than the patients with the GG genotype (P = 0.03). Haplotype analysis of 13 SNPs in the APM1 gene showed that estimates of haplotype frequencies in Swedish Caucasians are similar to those estimated in French Caucasians. However, no significant association of haplotypes with type 2 diabetes and IGT was detected in our study. The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes. 相似文献
78.
Hanna JN Ritchie SA Eisen DP Cooper RD Brookes DL Montgomery BL 《The Medical journal of Australia》2004,180(1):24-28
OBJECTIVE: To describe an outbreak of Plasmodium vivax malaria in Far North Queensland in 2002. DESIGN: Epidemiological and entomological investigations; molecular analyses of the infecting parasites. MAIN OUTCOME MEASURES: Case characteristics, adult and larval mosquito counts at the outbreak location, haplotyping of parasites in blood samples from different cases determined through sequencing of AMA1 and MSP1 genes. RESULTS: A man with imported P. vivax malaria stayed at a camping ground 95 km north of Cairns in late September 2002. This led to an outbreak of P. vivax malaria in 10 adults who stayed at the camping ground in October. Large numbers of Anopheles farauti sensu lato larvae were present in stagnant pools in a creek at the camping ground, and many adult mosquitoes were collected nearby. Not only had most of the infected patients been exposed to mosquitoes at night, they were also less likely than other campers to have used insect repellents appropriately (odds ratio, 0.01; P < 0.001). Two different haplotypes of P. vivax, only one of which was detected in the imported case, were involved in the outbreak. CONCLUSIONS: Although local transmission of malaria is rare in Far North Queensland, the risk is probably higher in the dry season (September to December). Campers need to be aware of the increased risk of mosquito-borne diseases. Sexual recombination of multiple gametocytes in mosquitoes infected by the imported case may have resulted in the two haplotypes of P. vivax involved in the outbreak. 相似文献
79.
Brookes D 《Nursing times》2002,98(23):36-38
Annual screening for patients with diabetes plays an important role in preventing complications. An audit carried out at a GP practice showed that housebound patients with diabetes were not receiving adequate treatment and support as they could not attend the clinic at the surgery. District nurses at the practice were trained in the management of diabetes and screened patients, who were then visited by a GP. The initiative highlighted a range of previously undetected problems with the patients' conditions, which were then addressed. The service is now available to newly diagnosed housebound patients with diabetes, as well as providing annual reviews for current patients. 相似文献
80.
Digerness SB Brookes PS Goldberg SP Katholi CR Holman WL 《The Journal of thoracic and cardiovascular surgery》2003,125(4):863-871
BACKGROUND: Preconditioning and inhibition of sodium-proton exchange attenuate myocardial ischemia-reperfusion injury by means of independent mechanisms that might act additively when used together. The hypothesis of this study is that treatment with a sodium-proton exchange inhibitor and a mitochondrial adenosine triphosphate-sensitive potassium channel opener produces superior functional recovery and a greater decrease in left ventricular infarct size compared with treatment with either drug alone in a model of severe global ischemia. METHODS: Isolated crystalloid-perfused rat hearts (n = 8 hearts per group) were administered vehicle (control, 0.04% dimethyl sulfoxide), diazoxide (100 micromol/L in 0.04% dimethyl sulfoxide), cariporide (10 micromol /L in 0.04% dimethyl sulfoxide), or diazoxide and cariporide before 40 minutes of ischemia at 35.5 degrees C to 36.5 degrees C and 30 minutes of reperfusion. RESULTS: The combination group had superior postischemic systolic function compared with that seen in the cariporide, diazoxide, and control groups (recovery of developed pressure: 91% +/- 7% vs 26% +/- 5%, 35% +/- 6%, and 16% +/- 3%, respectively; P <.05). Postischemic diastolic function in the combination group was superior compared with that seen in the other groups (change(pre-post) diastolic pressure of 67 +/- 4 mm Hg with control, 49 +/- 11 mm Hg with diazoxide, 59 +/- 10 mm Hg with cariporide, and 3 +/- 3 mm Hg with diazoxide and cariporide combination; P <.05). The left ventricular infarct area was less in the combination group compared with that in the cariporide, diazoxide, and control groups (6% +/- 2% vs 35% +/- 7%, 25% +/- 3%, and 37% +/- 9%, respectively; P <.05). CONCLUSIONS: Combining a selective mitochondrial adenosine triphosphate-sensitive potassium channel opener with a selective reversible inhibitor of sarcolemmal sodium-proton exchange improves recovery of contractile function from severe global ischemia in the isolated buffer-perfused rat heart. The putative mechanism for this benefit is superior protection of mitochondrial function. 相似文献