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排序方式: 共有1329条查询结果,搜索用时 984 毫秒
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Sarah E. Smith-Jeffcoat Mary A. Pomeroy Sadia Sleweon Samira Sami Jessica N. Ricaldi Yonathan Gebru Brianna Walker Shane Brady Matthew Christenberry Stephen Bart Johanna Vostok Stephanie Meyer Scott Seys Amanda Markelz Nicole Ditto Valerie Newbern Franda J. Thomas Deepam Thomas Enrico Cabredo Stephanie Kellner Vance R. Brown Jacqueline E. Tate Hannah L. Kirking 《MMWR. Morbidity and mortality weekly report》2022,71(7):238
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Yan Sun PhD Sameer C. Dhamne MS Alejandro Carretero-Guillén PhD Ricardo Salvador PhD Marti C. Goldenberg BS Brianna R. Godlewski BS Alvaro Pascual-Leone MD PhD Joseph R. Madsen MD Scellig S. D. Stone MD PhD Giulio Ruffini PhD Javier Márquez-Ruiz PhD Alexander Rotenberg MD PhD 《Annals of neurology》2020,88(3):489-502
64.
We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds. 相似文献
65.
Richard I. Rynes Gregory Krohel Anthony Falbo Robert D. Reinecke Bruce Wolfe Lee E. Bartholomew 《Arthritis \u0026amp; Rheumatology》1979,22(8):832-836
Ocular toxicity of long-term hydroxychloroquine treatment was assessed by regular ophthalmologic examinations in 99 patients. No patient developed significant loss of vision or visual field constriction to a white test object. Three patients had evidence of toxicity, but the medication had to be permanently discontinued in only one who subsequently had regression of all abnormalities except visual field constriction to a red test object. Neither duration of treatment nor the diagnosis of systemic lupus erythematosus predisposed patients to toxicity. 相似文献
66.
Origins of cerebral palsy 总被引:7,自引:0,他引:7
R L Naeye E C Peters M Bartholomew J R Landis 《American journal of diseases of children (1960)》1989,143(10):1154-1161
Analyses were undertaken to determine the causes of cerebral palsy in a prospective study of 43,437 full-term children. Presumed causes were found for about 71% of the 34 quadriplegic and 40% of the 116 nonquadriplegic patients with cerebral palsy. Risk estimates based on predictive models, adjusted for multiple factors, suggest that 53% of the quadriplegic patients with cerebral palsy could be attributed to congenital disorders, 14% to birth asphyxia, and 8% to other identified disorders. Thirty-five percent of the nonquadriplegic patients with cerebral palsy could be attributed to congenital disorders and 6% to other disorders. In the victims of cerebral palsy, characteristic consequences of birth asphyxia were more often the result of nonasphyxial disorders. These included meconium in the amniotic fluid, low 10-minute Apgar scores, neonatal apnea spells, seizures, persisting neurologic abnormalities, and slow head growth after birth. 相似文献
67.
Jim Klostergaard M. Elena Leroux H. -A. Hsu Bartholomew P. Hsi Zahid H. Siddik Lynn L. Danhauser Stephen P. Tomasovi 《Cancer chemotherapy and pharmacology》1995,37(3):235-241
Effective adjunctive therapies for colorectal carcinoma are clearly needed. We evaluated the cytotoxic responses in vitro of human colon carcinoma cell lines to combined modalities: 5-fluorouracil/leucovorin (5-FU/LV), carboplatin (CP), tumor necrosis factor (TNF) and hyperthermia (HTX). Cytotoxicity was evaluated in a cell proliferation assay using crystal violet staining. 5-FU/LV was administered 2–3 days before TNF and CP, followed 1 h later by HTX. These cell lines were relatively resistant to HTX alone (42°C for 2 h), but were heterogeneous in their responses to various doses of the other single agents. This heterogeneity was also evident for combined modalities: the geneity was also evident for combined modalities: the HCT-15 cell line exhibited significant supra-additivity for selected doses of CP, TNF and 5-FU/LV, which was further enhanced by hyperthermia. In contrast, the HT-29 cell line did not demonstrate a strong pattern for supra-additivity, whereas the DLD-1 cell line had an intermediate response. Thus, our results suggest one approach to develop effective and dose-sparing multimodality therapeutic regimens for colon adenocarcinoma. 相似文献
68.
Bartholomew NG Rowan-Szal GA Chatham LR Nucatola DC Simpson DD 《Journal of psychoactive drugs》2002,34(4):347-354
Women who enter drug abuse treatment programs are likely to report histories of sexual abuse that may impact psychosocial functioning, retention, and outcomes. This study investigates differences at admission between women with and without sexual abuse histories who entered an outpatient methadone treatment program in Texas. In a sample of 137 women, 39% reported prior sexual abuse. Findings show that women with sexual abuse histories were more likely also to have experienced physical and emotional abuse, to report poorer family-of-origin relationships, and to report more drug-related problems. These clients also reported more depression, anxiety, thoughts of suicide, trouble concentrating, and trouble controlling violent behavior. Results are discussed in terms of the need for adequate assessment of abuse history at intake and the need for targeted outcome studies to better define the impact of past abuse on treatment participation and outcome. 相似文献
69.
We describe a patient with diffuse polycystic disease of the liver. The patient's polycystic liver disease was found to be due to liver metastases from squamous cell carcinoma of the uterine cervix. No evidence of discrete masses was found in the liver using abdominal CT scan. Pseudocystic formation in the liver secondary to squamous cell carcinoma is very rare and has not previously been reported as a first presentation of a cervical cancer. Metastatic neoplasms need to be considered in the differential diagnosis of hepatic cysts. 相似文献
70.