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121.
Glória Abreu Carlos Galvão Braga João Costa Pedro Azevedo Jorge Marques 《Revista portuguesa de cardiologia》2018,37(8):707-713
Background
Spontaneous coronary artery dissection (SCAD) is an unusual cause of acute coronary syndrome (ACS). Better recognition and diagnosis has raised awareness of this condition. However, the pathophysiology of SCAD and its prognosis are still little understood. We aimed to investigate the characteristics and prognosis of patients with SCAD, and subsequently performed a review of literature.Methods
Single-center, retrospective study performed in patients hospitalized from January 2010 to December 2016 with suspected ACS (n=5002) whose final diagnosis was SCAD (n=27; 0.5%).Results
Patients with SCAD were mainly female (81.5%; n=22), with median age of 56. Predisposing factors were identified in 12 (44%) patients and precipitating factors in three (11.1%). Non-ST elevation myocardial infarction (NSTEMI) was the main form of presentation (51.9%). The left anterior descending artery (LAD) territory was the most commonly involved (n=12, 44.4%). Type 2 dissection was the most prevalent angiographic pattern (n=17, 63%). The majority of patients (n=15; 55.6%) were managed medically and the remaining patients underwent percutaneous coronary intervention (PCI) with drug-eluting stents. Seven patients re-infarcted while in the hospital. Over the median follow-up period of 20 months, 7.4% of patients (n=2) had symptoms of heart failure (HF) and 14.8% developed ACS (in three patients the event occurred in a coronary territory other than that of the index case, and in one patient it occurred in the previously affected territory). There were no deaths.Conclusion
In the studied population, SCAD was more prevalent in middle-aged women. Despite the high prevalence of in-hospital re-infarction or during follow-up, the prognosis was good overall. 相似文献122.
Effect of postural angle on back muscle activities in aging female workers
performing computer tasks
Nabilla Sofia Mohd Kamil Siti Zawiah Md Dawal 《Journal of Physical Therapy Science》2015,27(6):1967-1970
[Purpose] This study investigated the effects of postural angle on back muscle activity
during a computer task in aging women. [Subjects] Seventeen women ≥50 years old
participated. [Methods] The participants were instructed to perform computer-related tasks
for 20 minutes on a workstation that simulated typical office working conditions. Back
posture was measured from the measured trunk and pelvic angles. Electromyography
activities were recorded simultaneously from the cervical erector spinae, longissimus, and
multifidus muscles. [Results] The lowest mean percentages of maximum voluntary contraction
for the cervical erector spinae and longissimus muscles were obtained when the upper trunk
and pelvic angles were between 0° to −5° from the sagittal plane. The back muscle
activities increased as the upper trunk and pelvic angles exceeded 0°. Statistical
analysis showed significant correlations between upper trunk angle and cervical erector
spinae and longissimus muscle activities. Similarly, pelvic angle was significantly
correlated with cervical erector spinae and multifidus muscle activities. [Conclusion] A
neutral back posture minimizes muscle activities in aging women performing computer
tasks.Key words: Postural angle, Muscle activity, Aging 相似文献
123.
Alexandre Braga Libório Marcelo Boecker Munoz Braz Antonio Carlos Seguro Gdayllon C. Meneses Fernanda Macedo de Oliveira Neves Danielle Carvalho Pedrosa Luciano Pamplona de Góes Cavalcanti Alice Maria Costa Martins Elizabeth de Francesco Daher 《The American journal of tropical medicine and hygiene》2015,92(3):611-616
Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage. 相似文献
124.
Sack RB Siddique AK Longini IM Nizam A Yunus M Islam MS Morris JG Ali A Huq A Nair GB Qadri F Faruque SM Sack DA Colwell RR 《The Journal of infectious diseases》2003,187(1):96-101
How Vibrio cholerae spreads around the world and what determines its seasonal peaks in endemic areas are not known. These features of cholera have been hypothesized to be primarily the result of environmental factors associated with aquatic habitats that can now be identified. Since 1997, fortnightly surveillance in 4 widely separated geographic locations in Bangladesh has been performed to identify patients with cholera and to collect environmental data. A total of 5670 patients (53% <5 years of age) have been studied; 14.3% had cholera (10.4% due to V. cholerae O1 El Tor, 3.8% due to O139). Both serogroups were found in all locations; outbreaks were seasonal and often occurred simultaneously. Water-use patterns showed that bathing and washing clothes in tube-well water was significantly protective in two of the sites. These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks. 相似文献
125.
Maryam Sayah Md Christopher VandenBussche Md PhD Zahra Maleki Md 《Diagnostic cytopathology》2015,43(9):751-755
Epithelioid hemangioendothelioma (EHE) is a rare mesenchymal tumor of vascular origin with variable morphological features and unpredictable biological behavior. EHE occasionally involves the pleural fluid. However, the cytomorphology of EHE found in pleural fluid has not been well characterized in the literature. Herein we describe a case of EHE, initially presenting as multiple liver lesions plus several small nodular densities at the bases of the lungs followed by bilateral pleural effusions. Diagn. Cytopathol. 2015;43:751–755. © 2015 Wiley Periodicals, Inc. 相似文献
126.
Naveed Khan Muhammad Shoaib Akhtar Barkat Ali Khan Valdir de Andrade Braga Adam Reich 《Archives of Medical Science》2015,11(6):1261-1271
Introduction
Numerous herbal medicines have been recommended for the treatment of different diseases. Achyranthes aspera, Linn. (Family: Amaranthaceae), popularly known as Charchitta or Pitpapra, is commonly used by traditional healers for the treatment of fever, malaria, dysentery, asthma, arterial hypertension, pneumonia, and diabetes. The root extract is well reputed for its insect molting hormonal activity. This investigation was conducted to evaluate the effects of saponins from Achyranthes aspera seeds on the serum lipid profile of albino rats fed a high cholesterol diet.Material and methods
Hypolipidemic, antioxidant and hepatoprotective activities of these saponins were tested as described previously. To determine the mechanism underlying the observed effects, serum antioxidant status was assessed according to ABTS (2,2’-azino-bis-3-ethylbenzo-thiazoline-6-sulfonic acid), superoxide dismutase and ferric ion reducing antioxidant power (FRAP) assays in saponin-treated hyperlipidemic animals. Liver enzyme levels were determined to reveal any possible hepatotoxicity.Results
Four-week oral administration of A. aspera seed saponins produced a significant (p < 0.05) decrease of total cholesterol, total triglycerides and LDL-C and a significant increase of HDL-C level in hyperlipidemic rats. Treatment with A. aspera seed saponins also showed a significant (p < 0.01) improvement of serum antioxidant status in tested animals. No significant hepatotoxicity was produced by such treatment as the serum liver enzyme activity remained unaltered.Conclusions
Saponins from A. aspera seeds possess antihyperlipidemic and antioxidant properties which might lead to improvement of serum lipid profile and blood antioxidant status. Our findings support the folkloric use of this indigenous plant in the treatment of hyperlipidemia. However, its exact mechanism of action remains to be elucidated. 相似文献127.
128.
M. Barbot N. Albiger F. Ceccato M. Zilio A. C. Frigo L. Denaro F. Mantero C. Scaroni 《Pituitary》2014,17(2):109-117
Cushing’s disease (CD) is associated with increased morbidity and mortality. Until now, no medical treatment has been shown to be totally satisfactory when administrated alone. This study aimed to assess the effectiveness of cabergoline with added ketoconazole and of the same combination in reverse, using urinary free cortisol (UFC) and late night salivary cortisol (LNSC) levels as biochemical markers of the treatments’ efficacy in CD patients. A prospective analysis conducted on 14 patients (f/m = 12/2; median age 52, range 33–70 years) divided into two groups: 6 patients initially treated with cabergoline for 4–6 months (rising from 0.5–1 mg/week up to 3.0 mg/week), after which ketoconazole was added (group A); and 8 patients first took ketoconazole alone for 4–6 months (rising from 200 mg/day to 600 mg/day), then cabergoline was added (group B). Patients were compared with 14 age-matched patients in prolonged remission after effective neurosurgery for CD. The combination therapy led to UFC normalization in 79 % of patients with no differences between the groups; only one patient failed to respond at all. Neither drug succeeded in controlling the disease when taken alone. LNSC dropped when compared to baseline levels, but not to a significant degree (p = 0.06), and it remained significantly higher than in controls (p = 0.0006). Associating cabergoline with ketoconazole may represent an effective second-line treatment, achieving a satisfactory reduction in UFC levels and clinical improvement. Although the combined treatment lowered patients’ LNSC levels, they remained higher than normal, indicating a persistent subclinical hypercortisolism; the implications of this condition need to be considered. No differences emerged between the two treatment schedules. 相似文献
129.
Md. Sazzadul Islam Bhuyian Ronald Saxton Khaled Hasan Jahed Masud Fatema Zohura Shirajum Monira Shwapon Kumar Biswas M. Tasdik Hasan Tahmina Parvin Ismat Minhaj Kazi Md. Zillur Rahman Nowshin Papri Mahamud‐ur Rashid Lubaba Sharin Alana Teman Elizabeth D. Thomas Kelsey Alland Alain Labrique David A. Sack Jamie Perin Munirul Alam Christine Marie George 《Tropical medicine & international health : TM & IH》2020,25(8):985-995
130.
Lizzul Laura Lombardi Giuseppe Barbot Mattia Ceccato Filippo Gardiman Marina Paola Regazzo Daniela Bellu Luisa Mazza Elena Losa Marco Scaroni Carla 《Pituitary》2020,23(4):359-366
Pituitary - Aggressive pituitary adenomas (APAs) and pituitary carcinomas (PCs) are challenging for their invasive nature, resistance to treatment and recurrences. Temozolomide (TMZ) is... 相似文献