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排序方式: 共有4491条查询结果,搜索用时 0 毫秒
91.
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93.
E.S. Bloom 《Breast Diseases: A Year Book Quarterly》2012,23(3):271-272
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95.
S. N. Sullivan M. C. Champion N. D. Christofides T. E. Adrian S. R. Bloom 《The Physician and sportsmedicine》2013,41(7):77-82
In brief: Diarrhea is a common complaint of recreational and competitive runners. To test the hypothesis that running stimulates gut motility through a hormonal mechanism, we studied the effects of a 30-km run on plasma concentrations of gastrointestinal (GI) regulatory peptides in seven male marathon runners. Concentrations of insulin, enteroglucagon, neurotensin, and gastric inhibitory polypeptide did not change, but gastrin, motilin, somatostatin, pancreatic glucagon, pancreatic polypeptide, and vasoactive intestinal polypeptide increased. Epinephrine and norepinephrine also increased, which may partly explain the concentration changes. The increase in motilin was sufficient to stimulate gastric emptying and colonic motility, but further research is needed to determine whether these hormonal changes affect Gl function. 相似文献
96.
Evidence suggests a role for central dopaminergic activity in determining an individual's level of hypnotizability. The authors measured the correlation between blink rate, which has been shown to correlate with central dopaminergic activity, and hypnotizability. Forty-eight healthy participants were evaluated for hypnotizability by the Harvard Group Scales of Hypnotic Susceptibility and the Stanford Hypnotic Susceptibility Scale: Form C. Blink rate was assessed under conditions of conversation, staring at a cross, listening to music, and resting. Contrary to their hypothesis, the authors found a negative correlation between hypnotizability and blink rate, accounted for primarily by the higher blink rates at rest in medium as compared to high hypnotizables. The results do not provide evidence for a role of dopamine in determining hypnotizability. 相似文献
97.
David M. Gilligan Antonios Marsonis Jayshree Joshi Stephen R. Bloom Celia M. Oakley Petros Nihoyannopoulos Mohammad A. Ghatei 《Clinical cardiology》1996,19(2):129-135
Some patients with hypertrophic cardiomyopathy experience postprandial exacerbation of symptoms. The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients with postprandial symptoms, 10 patients without postprandial symptoms, and 10 normal subjects ate a 740 Kcal meal, following which heart rate, blood pressure, and echocardiographic and gastrointestinal hormone changes were compared among the three groups. Heart rate increased (p<0.001) and diastolic blood pressure fell (p < 0.001) to a similar degree in the three groups. Left ventricular outflow tract velocity increased (p< 0.01) and some patients had substantial increases in outflow tract pressure gradient; however, this was independent of the presence or absence of postprandial symptoms. The atrial contribution to filling increased in normal subjects and in both groups of hypertrophic cardiomyopathy patients. There was no significant difference in the gastrointestinal hormone changes in the three groups. In summary, there is no evidence for a distinctive hemodynamic or hormonal response to food in hypertrophic cardiomyopathy patients with postprandial symptoms. These symptoms more likely reflect differences in underlying cardiac disease characteristics and severity. 相似文献
98.
Carlson D Hernandez J Bloom BJ Coburn J Aversa JM Steere AC 《Arthritis and rheumatism》1999,42(12):2705-2709
OBJECTIVE: To determine whether Borrelia burgdorferi DNA may be detected in synovial tissue from patients with Lyme arthritis who have persistent synovial inflammation after antibiotic treatment. METHODS: Synovial specimens obtained at synovectomy from 26 patients with antibiotic treatment-resistant Lyme arthritis and from 10 control subjects were tested for B burgdorferi DNA using 3 primer-probe sets that target genes encoding outer surface proteins A or B or a flagellar protein (P41) of the spirochete. RESULTS: The 26 patients with Lyme arthritis, who had received antibiotic therapy for a mean total duration of 8 weeks prior to synovectomy, and the 10 control subjects each had negative polymerase chain reaction (PCR) results in synovial samples. When the samples were spiked with approximately 1-10 B burgdorferi, all but 1 had positive PCR results, suggesting that spirochetal DNA could have been detected in most of the unspiked samples if it had been present. CONCLUSION: These results indicate that synovial inflammation may persist in some patients with Lyme arthritis after the apparent eradication of the spirochete from the joint with antibiotic therapy. 相似文献
99.
Druce MR Wren AM Park AJ Milton JE Patterson M Frost G Ghatei MA Small C Bloom SR 《International journal of obesity (2005)》2005,29(9):1130-1136
OBJECTIVE: To investigate whether effects on food intake are seen in obese subjects receiving exogenous administration of ghrelin. DESIGN: Randomised, double-blind, placebo-controlled study of intravenous ghrelin at doses 1 pmol/kg/min and 5 pmol/kg/min. SUBJECTS: In all, 12 healthy lean subjects (mean body mass index (BMI) 20.5+/-0.17 kg/m(2)) and 12 healthy overweight and obese subjects (mean BMI 31.9+/-1.02 kg/m(2)). MEASUREMENTS: Food intake, appetite and palatability of food, ghrelin and other obesity-related hormones, growth hormone. RESULTS: Low-dose infusion of ghrelin increased ad libitum energy intake at a buffet meal in the obese group only (mean increase 36.6+/-9.4%, P<0.01.) High-dose ghrelin infusion increased energy intake in both groups (mean increase 20.1+/-10.6% in the lean and 70.1+/-15.5% in the obese, P<0.01 in both cases.) Ghrelin infusion increased palatability of food in the obese group. CONCLUSION: Ghrelin increases food intake in obese as well as lean subjects. Obese people are sensitive to the appetite-stimulating effects of ghrelin and inhibition of circulating ghrelin may be a useful therapeutic target in the treatment of obesity. 相似文献
100.
Electrical and mechanical alternation in pericardial effusion 总被引:3,自引:0,他引:3