Synthesis and antimicrobiological activity of N-aryl-substituted 2-methyl-3-carbethoxy-5-pyrrolinone derivatives

We describe the synthesis of N-aryl-2-methyl-3-carbethoxy-5-pyrrolinones benzylidene derivatives, their condensation with azomethines and substitution with aniline. The compounds have been tested for antimicrobial and fungicide activity: they have better fungicidal than bactericidal activity.     

Anticholinesterase activity of monoquaternary ammonium salts containing hydrophobic radicals

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 22, No. 6, pp. 686–691, June, 1988.     

The antialdolase activity of plague antiserum and differentiation between aldolase and toxin of Pasteurella pestis

Summary Antiplague serum possesses antialdolase activity. This activity is specific since it was not revealed in normal horse serum. Antialdolase of antiplague serum not only precipitates the aldolase contained in the preparations ofP.pestis toxin (fraction II), but also neutralizes it.By cross serological reactions and by experiments on animals it was revealed thatP.pestis aldolase and toxin were different antigens.Presented by Active Member AMN SSSR N. N. Zhukov-Verezhnikov Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 57, No. 4, pp. 84–87, April, 1964     

Clinical use of tramal in patients in the early postoperative period

Tramal was given to 204 patients who were operated on the lung, heart, abdomen. During pain therapy, good and satisfactory results were on average obtained in 75% patients operated on the lung, in 77%, on the heart, in 89%, on the abdomen, in 70%, on the great vessels. The absence of the inhibitory effect of the drug on the respiratory center and its slightly marked sedative effect allow one to recommend the agent for application in the early period following the surgery when narcotic analgesics still retain their effect and a real risk of their overdosage exists. During prolonged artificial pulmonary ventilation in the early postoperative period and in impaired adaptation of the patients to a respirator, tramal aids normalization of lung mechanics and hemodynamic parameters without eliminating and suppressing the patients' consciousness and results in cessation of muscular shivering. Adverse effects of tramal are of no decisive clinical significance and occur mainly when the drug is rapidly injected into the vein.     

A family with amyotrophic lateral sclerosis and parkinsonism

Zusammenfassung Bericht über einen 45jährigen Mann mit der Kombination von myatrophischer Lateralsklerose und Parkinson-Syndrome, dessen Vater ebenfalls diese Krankheitskombination aufwies. Die epidemiologische Bedeutung derartiger Fälle wird diskutiert unter Bezugnahme auf das gehäufte Vorkommen auf den Marianen-Inseln und die Mitteilungen für das familiäre Vorkommen in Europa. Ein gemeinsamer genetischer Faktor wird für wahrscheinlich gehalten.