全文获取类型
收费全文 | 533篇 |
免费 | 48篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 43篇 |
妇产科学 | 15篇 |
基础医学 | 63篇 |
口腔科学 | 11篇 |
临床医学 | 53篇 |
内科学 | 107篇 |
皮肤病学 | 29篇 |
神经病学 | 23篇 |
特种医学 | 83篇 |
外科学 | 37篇 |
综合类 | 21篇 |
预防医学 | 11篇 |
眼科学 | 7篇 |
药学 | 59篇 |
中国医学 | 1篇 |
肿瘤学 | 16篇 |
出版年
2021年 | 2篇 |
2019年 | 2篇 |
2017年 | 6篇 |
2016年 | 7篇 |
2015年 | 8篇 |
2014年 | 13篇 |
2013年 | 24篇 |
2012年 | 4篇 |
2011年 | 8篇 |
2010年 | 24篇 |
2009年 | 26篇 |
2008年 | 15篇 |
2007年 | 12篇 |
2006年 | 14篇 |
2005年 | 14篇 |
2004年 | 8篇 |
2003年 | 14篇 |
2002年 | 12篇 |
2001年 | 5篇 |
1999年 | 6篇 |
1998年 | 20篇 |
1997年 | 42篇 |
1996年 | 31篇 |
1995年 | 20篇 |
1994年 | 24篇 |
1993年 | 23篇 |
1992年 | 16篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 29篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 14篇 |
1985年 | 16篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 14篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1969年 | 2篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1955年 | 1篇 |
1932年 | 1篇 |
1912年 | 1篇 |
排序方式: 共有581条查询结果,搜索用时 15 毫秒
41.
42.
43.
Disease-free survival after autologous bone marrow transplantation in patients with acute myelogenous leukemia 总被引:1,自引:0,他引:1
Korbling M; Hunstein W; Fliedner TM; Cayeux S; Dorken B; Fehrentz D; Haas R; Ho AD; Keilholz U; Knauf W 《Blood》1989,74(6):1898-1904
Autologous bone marrow transplantation (ABMT) makes it possible to escalate the dose of cytotoxic treatment to a lethal range. Disease- free survival (DFS) following myeloablative therapy and ABMT has been shown to be superior to conventional treatment in high risk patients with acute myelogenous leukemia (AML). It was the purpose of the present study to compare hematopoietic reconstitution, actuarial DFS, and relapse rate of patients transplanted in first complete remission (CR) of AML with those in second or subsequent CR, and to evaluate transplant related mortality. Fifty-two patients with AML, 22 in first CR (low risk) and 30 in second or subsequent CR (high risk), underwent total body irradiation (12.1 to 16.7 Gy) and cyclophosphamide (CY) treatment (200 mg/kg) followed by ABMT. The autograft was incubated with the active CY derivative Mafosfamide (ASTA Werke, Bielefeld, Federal Republic of Germany) to reduce the number of possibly contaminating clonogenic tumor cells. All patients showed three lineage engraftments with platelet recovery observed as being the slowest. The transplant related death rate was low at 5.8%. There was no significant difference in the kinetics of polymorphonuclear (PMN) cell or platelet reconstitution between the low and high risk patient subgroups. The estimated probability of DFS (relapse) after ABMT in first CR was 61% (36%) compared with 34% (65%) in second or subsequent CR, the longest follow-up being 55 months and 57 months, respectively (median follow-up 31 months and 19 months, respectively). ABMT offers a stable long-term DFS when performed in first CR with no relapses occurring in over a year after transplantation. Six later relapses, however, were seen after ABMT in second or subsequent CR, although DFS was not statistically different from that of first remission patients (P = .72). 相似文献
44.
Moore AD; Godwin JD; Muller NL; Naidich DP; Hammar SP; Buschman DL; Takasugi JE; de Carvalho CR 《Radiology》1989,172(1):249-254
The authors retrospectively evaluated radiographs, computed tomographic (CT) scans, and results of pulmonary function tests (when available) for 17 patients with biopsy-proved pulmonary histiocytosis X. In 11 patients, high-resolution CT was used. In 12 patients, CT demonstrated cystic air spaces, usually less than 10 mm in diameter. In three of these 12, cysts were the only abnormality, but in six others, nodules (usually less than 5 mm in diameter) were also present. Two patients had only nodules and one, only emphysema. CT showed that many lesions that appeared reticular on plain radiographs were actually cysts. CT showed no central or peripheral concentration of lesions, but it did reveal that many small nodules were distributed in the centers of secondary lobules around small airways. CT findings correlated better with the diffusing capacity (rho = -0.71) than did the plain radiographic findings (rho = -0.57). Thus, CT was better than radiography at showing the morphology and distribution of lung abnormalities. 相似文献
45.
JH Burridge DE Wood HJ Hermens GE Voerman GR Johnson F. Van Wijck T. Platz M. Gregoric R. Hitchcock AD Pandyan 《Disability and rehabilitation》2005,27(1):69-80
Purpose: To discuss the measurement of spasticity in the clinical and research environments, make recommendations based on the SPASM reviews of biomechanical, neurophysiological and clinical methods of measuring spasticity and indicate future developments of measurement tools. Method: Using the results of the systematic reviews of the biomechanical, neurophysiological and clinical approaches, methods were evaluated across three dimensions: (1) validity, reliability and sensitivity to change; (2) practical quality such as ease of use and (3) qualities specific to the measurement of spasticity, for example ability to be applied to different muscle groups. Methods were considered in terms of applicability to research and clinical applications. Results: A hierarchy of measurement approaches was identified from highly controlled and more objective (but unrelated to function) to ecologically valid, but less objective and subject to contamination from other variables. The lack of a precise definition of spasticity may account for the problem of developing a valid, reliable and sensitive method of measurement. The reviews have identified that some tests measure spasticity per se, some phenomena associated with spasticity or consequential to it and others the effect of spasticity on activity and participation and independence. Conclusions: Methods appropriate for use in research, particularly into the mechanism of spasticity did not satisfy the needs of the clinician and the need for an objective but clinically applicable tool was identified. A clinical assessment may need to generate more than one 'value' and should include evaluation of other components of the upper motor neurone syndrome. There is therefore a need for standardized protocols for 'best practice' in application of spasticity measurement tools and scales. 相似文献
46.
I. W. Reimann C. Britzelmeier P. Haber H. Wollmann K. H. Antonin P. R. Bieck 《European journal of clinical pharmacology》1987,33(2):147-150
Summary The specific binding (Bmax) of (3H-methyl)yohimbine to alpha2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection.A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha2-adrenoceptor binding sites on intact platelets was not found. 相似文献
47.
Occult fractures of the proximal femur: MR imaging 总被引:9,自引:0,他引:9
48.
IJ Webb ; CE Eickhoff ; AD Elias ; LJ Ayash ; CA Wheeler ; GN Schwartz ; GD Demetri ; KC Anderson 《Transfusion》1996,36(2):160-167
BACKGROUND: Peripheral blood progenitor cells (PBPCs) are commonly collected and used to reconstitute hematopoiesis after high-dose chemotherapy. However, strategies for optimal collection and assessment of leukapheresis components are not standardized. STUDY DESIGN and METHODS: Hematopoietic progenitor cell assays were performed on 369 leukapheresis components collected from 95 patients who had received doxorubicin-based chemotherapy and/or granulocyte-colony-stimulating factor (G-CSF). Precollection patient hematologic values, leukapheresis collection values, component hematopoietic progenitor cell assays, and patient outcome measures were summarized. The kinetics of mononuclear cell (MNC) and PBPC mobilization were assessed among four patient groups. RESULTS: Patient group was a significant predictor of the peripheral blood MNC count on the day of collection (p<0.0001), and that value was a significant predictor of granulocyte-macrophage– colony-forming unit (CFU-GM) yield (p<0.0001). This relationship between the peripheral blood MNC count on the day of collection and CFU- GM yield differed according to patient group (p<0.0001). CFU-GM made up a larger fraction of peripheral blood MNCs collected from patients who received chemotherapy plus G-CSF than collected from those who received G-CSF alone. Moreover, the peripheral blood MNC count and the corresponding CFU-GM yield increased significantly on consecutive days of collection in patient groups receiving chemotherapy and G-CSF but were unchanged or decreased in patients receiving G-CSF alone. CONCLUSION: The relationship between peripheral blood MNC count and leukapheresis component CFU-GM yield differed significantly between patients who received chemotherapy and G-CSF and those who received G- CSF alone for the mobilization of PBPCs. Patient peripheral blood MNC count and component CFU-GM yield are useful for both assessing and suggesting revisions to PBPC mobilization and collection strategies. 相似文献
49.
50.
Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia 总被引:1,自引:0,他引:1
AD Auerbach ; Q Liu ; R Ghosh ; MS Pollack ; GW Douglas ; HE Broxmeyer 《Transfusion》1990,30(8):682-687
Reported here are studies of Fanconi anemia fetal cells that led to the first use of umbilical cord blood for hematopoietic reconstitution in a clinical trial. Prenatal diagnosis and HLA typing were performed in fetuses at risk for Fanconi anemia (FA) to identify, prior to birth, those that were unaffected with the syndrome and were HLA-identical to affected siblings. Umbilical cord blood was harvested at the delivery of these infants; assays of progenitor cells indicated the presence of colony-forming units-granulocyte-macrophage (CFU-GM) in numbers similar to those of bone marrow CFU-GM that are associated with successful engraftment in HLA-matched allogeneic bone marrow transplantation. The possibility that umbilical cord blood from a single individual can be used as an alternative to bone marrow for hematopoietic reconstitution has now been demonstrated by the successful engraftment of two patients with FA. Progenitor cell assays of umbilical cord blood collected at the birth of a child affected with FA, who had been misdiagnosed on the basis of chorionic villus sampling (CVS) studies, indicated a profound deficiency in colony formation, consistent with previously reported abnormalities in the growth of FA cells in vitro. These results suggest that the hematopoietic disorder in FA is related to an underlying problem with cell proliferation. 相似文献