总被引：2，自引：0，他引：2  

Oestmann  JW; Greene  R; Kushner  DC; Bourgouin  PM; Linetsky  L; Llewellyn  HJ 《Radiology》1988,166(2):451-453

The influence of viewing time on the detectability of subtle and obvious lung cancers was studied. Frontal chest radiographs of 40 patients with subtle cancers, 40 patients with obvious cancers, and 40 healthy control subjects were shown to four observers for four different viewing times (0.25 second, 1 second, 4 seconds, and unlimited time). Receiver operating characteristic analysis was used to compare the detectability of lesions. Performance was degraded as viewing time decreased. The true-positive fractions for subtle and obvious cancers were 30% and 70% at 0.25 second and 74% and 98% at unlimited viewing time, respectively, for a given false-positive fraction of 20%. Thus, even with unlimited viewing time, the false-negative fraction for subtle cancers was 26%. The difference in detectability between subtle and obvious lung cancers was exaggerated at 1.0 second compared with 4 seconds and unlimited viewing time. The following conclusions were reached: (a) a substantial proportion of subtle lung lesions are missed, even with unlimited viewing time; (b) a large proportion of obvious lung cancers are detected with flash viewing; (c) the detectability of lesions decreases considerably as viewing time becomes less than 4 seconds; and (d) differences in detectability are exaggerated by short viewing times.  相似文献   

  总被引：2，自引：0，他引：2  

Soila  KP; Viamonte  M  Jr; Starewicz  PM 《Radiology》1984,153(3):819

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  总被引：13，自引：0，他引：13  

Turner  DA; Templeton  AC; Selzer  PM; Rosenberg  AG; Petasnick  JP 《Radiology》1989,171(1):135-140

Six painful hips in five patients were examined with magnetic resonance (MR) imaging and were found to have diffuse signal abnormalities in the marrow of the femoral head and neck, which extended into the intertrochanteric area in five cases. The abnormal regions were low in signal intensity on images obtained with a short repetition time (TR) and a short echo time (TE) and were isointense or hyperintense on long TR/TE images--findings that have been attributed by others to bone marrow edema. Edema was also seen in marrow just above the acetabulum in two cases. No focal abnormalities characteristic of osteonecrosis were seen. Osteonecrosis was subsequently shown to be present in all six femoral heads at core biopsy (three cases) or by subsequent development of focal MR abnormalities reported to be highly specific for osteonecrosis (three cases). The affected hips had been radiographically normal or subtly osteopenic and had shown intense radionuclide uptake in the femoral head at scintigraphy, with lesser abnormality in the neck and intertrochanteric region. Follow-up MR examinations of five of the six femoral heads showed the diffuse abnormalities to have been transient. Although diffuse MR abnormalities in the proximal femur are not specific, they may indicate the presence of osteonecrosis of the femoral head.  相似文献   

  总被引：1，自引：0，他引：1  

Bret  PM; Bretagnolle  M; Gaillard  D; Plauchu  H; Labadie  M; Lapray  JF; Roullaud  Y; Cooperberg  P 《Radiology》1985,154(1):7-10

Ultrasound (US) detected 27 small, asymptomatic renal angiomyolipomas in 18 patients. Twenty-five lesions were diffusely hyperechoic and 2 were heterogeneous. Nephrotomography was positive in 8 out of 12 patients (67%), CT in 12/14 (86%), and angiography in 10/14 (71%). Percutaneous fine-needle biopsy confirmed the diagnosis in 8 out of 12 patients (67%). Nephrotomography and angiography were nonspecific, whereas CT and biopsy were most specific because of the presence of fatty tissue. Angiography helped clarify the degree of vascularity of the masses. If the diagnosis can be made preoperatively, more conservative management can be undertaken.  相似文献   

    

Som  PM; Lanzieri  CF; Sacher  M; Lawson  W; Biller  HF 《Radiology》1985,154(2):407-412

Twenty-eight patients had combined conventional drip infusion CT scans. The information about the anatomic location of the lesion, its configuration, its cross-sectional appearance, its vascularity (as determined by dynamic signature curves), and its clinical presentation were considered as a single overall unit. This diagnostic approach allowed a diagnosis to be made on virtually all of these enhancing lesions without resorting to either a digital venous imaging study or angiographic procedure. In 17 of these cases, such an invasive second procedure was performed either to confirm the CT impression as part of this study or as part of a therapeutic embolization procedure.  相似文献   

    

Chong Guan Ng  Marco PM Boks  Hugo Matthias Smeets  Nor Zuraida Zainal  Niek J. de Wit 《Psycho-oncology》2013,22(4):762-767

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Soo Khai Ng MBBS  John PM Wood DPhil  Glyn Chidlow DPhil  Guoge Han MBBS  Thaksaon Kittipassorn MD  Daniel J Peet PhD  Robert J Casson DPhil FRANZCO 《Clinical & experimental ophthalmology》2015,43(4):367-376

The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina.  相似文献   

    

O'Sam Shibeeb MOphth  Glyn Chidlow DPhil  Guoge Han PhD  John PM Wood DPhil  Robert J Casson DPhil FRANZCO 《Clinical & experimental ophthalmology》2016,44(1):24-32

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  总被引：26，自引：1，他引：25  

Rao  PM; Rhea  JT; Novelline  RA; McCabe  CJ; Lawrason  JN; Berger  DL; Sacknoff  R 《Radiology》1997,202(1):139

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  总被引：7，自引：1，他引：6  

Migraine  S; Atri  M; Bret  PM; Lough  JO; Hinchey  JE 《Radiology》1997,205(1):55

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