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61.
Simon R Thompson Steve E Humphries Mark G Thomas Rosemary Ekong Ayele Tarekegn Endeshaw Bekele Olivia Creemer Neil Bradman Krishna R Veeramah 《European journal of human genetics : EJHG》2013,21(4):465-468
Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk. 相似文献
62.
Background
More than two thirds of the total population of Ethiopia is estimated to be at risk of malaria. Therefore, malaria is the leading public health problem in Ethiopia.Objective
To investigate the determinants of malaria Rapid Diagnosis Test (RDT) result and the association between socio-economic, demographic and geographic factors.Method
The study used data from household cluster malaria survey which was conducted from December 2006 to January 2007. A total of 224 clusters of about 25 households each were selected from the Amhara, Oromiya and Southern Nation Nationalities and People (SNNP) regions of Ethiopia. A multiple correspondence analysis was used to jointly analyse malaria RDT result, socio-economic, demographic and geographic factors.Results
The result from multiple correspondence analysis shows that there is association between malaria RDT result and different socio-economic, demographic and geographic variables.Conclusion
There is an indication that some socio-economic, demographic and geographic factors have joint effects. It is important to confirm the association between socio-economic, demographic and geographic factors using advanced statistical techniques. 相似文献63.
64.
Ashenfai A Yirga Sileshi F Melesse Henry G Mwambi Dawit G Ayele 《African health sciences》2020,20(4):1546
BackgroundThis study aims to make use of a longitudinal data modelling approach to analyze data on the number of CD4+cell counts measured repeatedly in HIV-1 Subtype C infected women enrolled in the Acute Infection Study of the Centre for the AIDS Programme of Research in South Africa.MethodologyThis study uses data from the CAPRISA 002 Acute Infection Study, which was conducted in South Africa. This cohort study observed N=235 incident HIV-1 positive women whose disease biomarkers were measured repeatedly at least four times on each participant.ResultsFrom the findings of this study, post-HAART initiation, baseline viral load, and the prevalence of obese nutrition status were found to be major significant factors on the prognosis CD4+ count of HIV-infected patients.ConclusionEffective HAART initiation immediately after HIV exposure is necessary to suppress the increase of viral loads to induce potential ART benefits that accrue over time. The data showed evidence of strong individual-specific effects on the evolution of CD4+ counts. Effective monitoring and modelling of disease biomarkers are essential to help inform methods that can be put in place to suppress viral loads for maximum ART benefits that can be accrued over time at an individual level. 相似文献
65.
John M. Nesemann Michael I. Seider Blake M. Snyder Robi N. Maamari Daniel A. Fletcher Berhan A. Haile Zerihun Tadesse Nicole E. Varnado Sun Y. Cotter Elizabeth Kelly Callahan Paul M. Emerson Todd P. Margolis Thomas M. Lietman Jeremy D. Keenan 《The American journal of tropical medicine and hygiene》2020,103(6):2488
66.
Geleta Geshere Oli Fasil Tekola Ayele Beyene Petros 《Tropical medicine & international health : TM & IH》2012,17(6):722-726
Objective To determine whether the elephantiasis in Midakegn district, central Ethiopia, is filarial or non‐filarial (podoconiosis) using serological, parasitological and clinical examinations, and to estimate its prevalence. Methods At house‐to‐house visits in 330 randomly selected households, all household members who had elephantiasis were interviewed and clinically examined at the nearby health centre to confirm the presence of elephantiasis, check the presence of scrotal swelling and rule out the other causes of lymphoedema. A midnight blood sample was obtained from each participant with elephantiasis for microscopic examination of Wuchereria bancrofti microfilaria. A daytime blood sample was obtained from half of the participants for serological confirmation using the immuno‐chromatographic test card. Results Consistent with the features of podoconiosis, none of the elephantiasis cases had consistently worn shoes since childhood; 94.3% had bilateral swelling limited below the level of the knees; no individual had thigh or scrotal elephantiasis; parasitological test for microfilariae and serological tests for W. bancrofti antigen were negative in all samples. The prevalence of the disease was 7.4% and it peaked in the third decade of life, the most economically active age. Conclusion Midakegn District has a high prevalence of podoconiosis and no filarial elephantiasis. Prevention, treatment and control of podoconiosis must be among the top priorities of public health programmes. 相似文献
67.
Keenan JD Ayele B Gebre T Moncada J Stoller NE Zhou Z Porco TC McCulloch CE Gaynor BD Emerson PM Schachter J Lietman TM 《Clinical infectious diseases》2012,54(2):253-256
Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7). 相似文献
68.
Scott D. Nash Ambahun Chernet Paul Weiss Andrew W. Nute Mulat Zerihun Eshetu Sata Demelash Gessese Kimberly A. Jensen Zebene Ayele Berhanu Melak Taye Zeru Abdulkerim Mengistu Adisu Abebe Fikre Seife Zerihun Tadesse E. Kelly Callahan 《The American journal of tropical medicine and hygiene》2023,108(2):261
69.
70.
Gizachew Ayele Belay Tessema Anteneh Amsalu Getachew Ferede Gizachew Yismaw 《BMC immunology》2018,19(1):37