全文获取类型
收费全文 | 11257篇 |
免费 | 649篇 |
国内免费 | 69篇 |
专业分类
耳鼻咽喉 | 123篇 |
儿科学 | 318篇 |
妇产科学 | 225篇 |
基础医学 | 1656篇 |
口腔科学 | 166篇 |
临床医学 | 1083篇 |
内科学 | 1870篇 |
皮肤病学 | 453篇 |
神经病学 | 1238篇 |
特种医学 | 595篇 |
外国民族医学 | 2篇 |
外科学 | 1842篇 |
综合类 | 119篇 |
一般理论 | 1篇 |
预防医学 | 746篇 |
眼科学 | 153篇 |
药学 | 755篇 |
中国医学 | 40篇 |
肿瘤学 | 590篇 |
出版年
2022年 | 81篇 |
2021年 | 151篇 |
2020年 | 121篇 |
2019年 | 134篇 |
2018年 | 183篇 |
2017年 | 168篇 |
2016年 | 180篇 |
2015年 | 242篇 |
2014年 | 270篇 |
2013年 | 424篇 |
2012年 | 512篇 |
2011年 | 545篇 |
2010年 | 342篇 |
2009年 | 320篇 |
2008年 | 443篇 |
2007年 | 531篇 |
2006年 | 481篇 |
2005年 | 491篇 |
2004年 | 432篇 |
2003年 | 410篇 |
2002年 | 409篇 |
2001年 | 419篇 |
2000年 | 393篇 |
1999年 | 324篇 |
1998年 | 169篇 |
1997年 | 137篇 |
1996年 | 101篇 |
1995年 | 99篇 |
1994年 | 90篇 |
1993年 | 87篇 |
1992年 | 177篇 |
1991年 | 196篇 |
1990年 | 146篇 |
1989年 | 172篇 |
1988年 | 179篇 |
1987年 | 159篇 |
1986年 | 165篇 |
1985年 | 119篇 |
1984年 | 110篇 |
1983年 | 113篇 |
1982年 | 74篇 |
1981年 | 60篇 |
1979年 | 73篇 |
1978年 | 67篇 |
1977年 | 62篇 |
1976年 | 61篇 |
1975年 | 72篇 |
1974年 | 65篇 |
1973年 | 81篇 |
1971年 | 69篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
H. H. Hennemann W. Wundt R. Schuh B. Bauer 《Journal of molecular medicine (Berlin, Germany)》1986,64(11):512-517
Summary Acute leukaemia was complicated by pneumonia in 38 (34.8%) of 109 patients treated between 1979 and 1983; in 39.5% of the patients pneumonia occurred more than once. In 23 patients (60.5%) pneumonia occurred during cytostatic therapy, and 25 patients (65.8%) had less than 1000 mm2 granulocytes. Antibiotic therapy had no or only little effect in 70%. A total of 21 patients (55.3%) died of pneumonia. In 15 patients a direct relationship could be seen between pneumonia and the bacterial spectrum in the sputum. A prevalence of gram-negative bacteria was found (24 of 40 bacteria isolated, especially Enterobacteriaceae (19). Fungi were cultivated in 10 cases. Each of the typical pneumonia bacteria was only seen once respectively. It is most important that therapy begin immediately, even before the bacteria have been identified. Only then is there hope that the survival time of patients with acute leukaemia can be influenced. 相似文献
62.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献
63.
Auditory Discrimination and the Eyeblink 总被引:1,自引:0,他引:1
Lance O. Bauer Barbara D. Strock Robert Goldstein John A. Stern Larry C. Walrath 《Psychophysiology》1985,22(6):636-641
This experiment evaluated the association between blinking and cognitive activities. Subjects received 200 and 400 ms tones (1 KHz) at fixed intervals in a duration discrimination paradigm. One group (“Task”) was instructed to respond to the stimuli on the basis of duration and another (“No-Task”) was instructed to ignore the stimuli. Blink activity (latency, rate, duration) and performance (RT, hit and false alarm rates) measures were evaluated. A first analysis (Task subjects only) indicated that stimulus duration had significant effects on RT and blink latency; both were generally longer following the 400-ms than the 200-ms stimuli. In a second analysis, involving Task and No-Task subjects, blink latencies were shorter in the Task group. Blink and eyelid closure durations increased over the task period in both analyses. These effects suggest that blinks occur when attentional processes wane. 相似文献
64.
65.
Clineff TD Erbe EM Bauer TW Carroll BE 《Journal of biomedical materials research. Part B, Applied biomaterials》2005,72(1):125-130
Synthetic calcium phosphate bone void fillers promote varying rates of bone formation and material resorption depending on chemistry, porosity, pore structure, and implant site. The objective of this study was to quantify the resorption of a novel ultraporous beta-tricalcium phosphate cancellous bone void filler with simultaneous quantification of bone formation in a canine humerus model. Potential measurement error involved in conventional histomorphometry using Von Kossa stains inspired the development of a new technique. This technique utilizes bright-field and polarized-light microscopy in conjunction with image analysis software, allowing more accurate histomorphometry. This technique was validated with two separate controlled experiments. Scanning electron microscopy further supported the results. The findings suggest that the use of polarized-light microscopy combined with image analysis software can be an effective tool in simultaneously quantifying calcium phosphate resorption and bone formation. 相似文献
66.
Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni,Co and Mn ions 总被引:2,自引:0,他引:2
Kohlhardt M. Bauer B. Krause H. Fleckenstein A. 《Pflügers Archiv : European journal of physiology》1973,338(2):115-123
Pflügers Archiv - European Journal of Physiology - According to earlier studies on mammalian papillary muscles, Ni and Co ions reduce the Ca dependent mechanical response whilst the action... 相似文献
67.
68.
Bauer E Gendo A Madl C Garo F Roth E Kramer L 《The International journal of artificial organs》2002,25(10):923-928
In cirrhotic patients, plasma amino acid levels are severely deranged. A decreased ratio of branched-chain to aromatic amino acids (Fischer ratio) has been implicated in the pathogenesis of hepatic encephalopathy. In this prospective study, we investigated the effects of extracorporeal detoxification on amino acid levels using a sorbent suspension dialysis system. Twenty patients with documented cirrhosis and hepatic encephalopathy grade II-III not responding to standard treatment were randomized to receive either six hours of sorbent dialysis and standardized conventional medical treatment or ongoing medical treatment alone. In contrast to previous uncontrolled studies, no significant effect on amino acid levels, Fischer ratio or clinical grade of hepatic encephalopathy was detected in either treatment group. In conclusion, a 6-hour treatment with sorbent dialysis did not significantly influence plasma levels of amino acids and did not ameliorate the clinical grade of hepatic encephalopathy. 相似文献
69.
Summary 100 stool extracts from patients with poliomyelitis or from individuals after oral poliomyelitis vaccination were inoculated simultaneously into HeLa, monkey kidney, and human thyroid cultures. In most cases (88 times) a cytopathic effect was seen in all three cultures. Failures were most frequently encountered in thyroid, rarely in monkey kidney cells. They were due either to thyroid culture lots with reduced viral susceptibility or to small amounts of virus in the stool specimens. No qualitative difference was found in the host range of individual virus strains. With attenuated viruses the cytopathic effect in HeLa cells as a rule was delayed for several days.
Die Untersuchungen wurden mit Unterstützung der Deutschen Vereinigung zur Bekmpfung der Kinderlähmung e.V. durchgeführt.
Wir danken Herrn Privatdoz. Dr. F.Müller, Düsseldorf, für die freundliche überlassung einiger virushaltiger Stuhlproben. Herr Dr. A. R.Ababio, Homburg, war uns bei der Beschaffung von Stuhlproben nach oraler Poliomyelitisimpfung behilflich. Wir danken schließlich Fräulein E.Baschleben, Frau H.Gelderblom, Frau H.Kaiser und Fräulein I.Lamy für ihre Hilfe bei den Untersuchungen. 相似文献
Die Untersuchungen wurden mit Unterstützung der Deutschen Vereinigung zur Bekmpfung der Kinderlähmung e.V. durchgeführt.
Wir danken Herrn Privatdoz. Dr. F.Müller, Düsseldorf, für die freundliche überlassung einiger virushaltiger Stuhlproben. Herr Dr. A. R.Ababio, Homburg, war uns bei der Beschaffung von Stuhlproben nach oraler Poliomyelitisimpfung behilflich. Wir danken schließlich Fräulein E.Baschleben, Frau H.Gelderblom, Frau H.Kaiser und Fräulein I.Lamy für ihre Hilfe bei den Untersuchungen. 相似文献
70.
H. W. Bauer 《Journal of molecular medicine (Berlin, Germany)》1981,59(4):149-155
Summary Long-term studies of 2-PAG in sera of patients with breast cancer, bronchial carcinoma, gynaecological carcinoma, melanoma and laryngeal carcinoma have proved that 2-PAG is a possible laboratory parameter for the assessment of recurrence of tumour and metastasis. The results published for trophoblastic tumour and gastrointestinal carcinoma are still divergent. Because of the large individual range of 2-PAG concentrations and the widely differing 2-PAG levels in men and women single determinations of this protein are without value. A detailed classification of the pathological mechanisms to which these proteins are submitted is still missing and consequently we have no fundamental knowledge of diseases that apart from pregnancy and neoplasia lead to changes in the physiological 2-PAG serum concentration.Dedicated to Prof. Dr. E. Schmiedt to his 60th birthday (20th of November 1980) 相似文献