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排序方式: 共有4423条查询结果,搜索用时 15 毫秒
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Samir Abdallah Hanna Alfredo Carlos Simões Dornellas de Barros Felipe Eduardo Martins de Andrade Jose Luiz Barbosa Bevilacqua José Roberto Morales Piato Edilson Lopes Pelosi Eduardo Martella João Luis Fernandes da Silva Heloisa de Andrade Carvalho 《International journal of radiation oncology, biology, physics》2014
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Ilda Patrícia Ribeiro Francisco Marques Francisco Caramelo José Ferrão Hugo Prazeres Maria José Julião Widad Rifi Suvi Savola Joana Barbosa de Melo Isabel Poiares Baptista Isabel Marques Carreira 《Tumour biology》2014,35(5):4687-4695
Oral tumors are a growing health problem worldwide; thus, it is mandatory to establish genetic markers in order to improve diagnosis and early detection of tumors, control relapses and, ultimately, delineate individualized therapies. This study was the first to evaluate and discuss the clinical applicability of a multiplex ligation-dependent probe amplification (MLPA) probe panel directed to head and neck cancer. Thirty primary oral squamous cell tumors were analyzed using the P428 MLPA probe panel. We detected genetic imbalances in 26 patients and observed a consistent pattern of distribution of genetic alterations in terms of losses and gains for some chromosomes, particularly for chromosomes 3, 8, and 11. Regarding the latter, some specific genes were highlighted due to frequent losses of genetic material—RARB, FHIT, CSMD1, GATA4, and MTUS1—and others due to gains—MCCC1, MYC, WISP1, PTK2, CCND1, FGF4, FADD, and CTTN. We also verified that the gains of MYC and WISP1 genes seem to suggest higher propensity of tumors localized in the floor of the mouth. This study proved the value of this MLPA probe panel for a first-tier analysis of oral tumors. The probemix was developed to include target regions that have been already shown to be of diagnostic/prognostic relevance for oral tumors. Furthermore, this study emphasized several of those specific genetic targets, suggesting its importance to oral tumor development, to predict patients’ outcomes, and also to guide the development of novel molecular therapies. 相似文献
85.
William Marciel de Souza Gustavo Olszanski Acrani Marilia Farignoli Romeiro Osvaldo Reis Júnior Aline Lavado Tolardo Amanda Araújo Serrão de Andrade João Lídio da Silva Gonçalves Vianez Júnior Daniele Barbosa de Almeida Medeiros Márcio Roberto Teixeira Nunes Luiz Tadeu Moraes Figueiredo 《Archives of virology》2016,161(8):2325-2328
86.
Fátima Karoline Araújo Alves Dultra Adna Conceição Barros Helenemarie Schaer‐Barbosa Andréia Leal Figueiredo Clarissa Araújo Silva Gurgel Eduardo Antônio Gonçalves Ramos Ana Maria da Silva Carvalho Jean Nunes dos Santos 《Journal of oral pathology & medicine》2012,41(1):47-53
J Oral Pathol Med (2012) 41 : 47–53 Objective: The aim of this study was to investigate the presence of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors. Methods: Twenty‐seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E‐cadherin. Results: A significant difference regarding the mean density of CD1a‐positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a‐positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a‐positive cells were detected in one mucoepidermoid carcinoma case, and six low‐grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a‐positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E‐cadherin between tumors (P = 0.73), but it was detected in 24 cases. Conclusions: The lack of CD1a‐positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E‐cadherin mediates cell adhesion in these tumors although we did not demonstrate significance. 相似文献
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Dallago CM Abech DD Pereira-Lima JF Leães CG Batista RL Trarbach EB Oliveira Mda C 《Pituitary》2008,11(1):109-112
Kallmann syndrome (KS) is a developmental disease characterized by the association of isolated hypogonadotropic hypogonadism
and anosmia/hyposmia. We report an unusual presentation of two females with KS and empty sella. These females, aged at 20
and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant
clinical signs were observed. Empty sella was observed on MRI in both cases. Sequencing of FGFR1 gene, recently implicated in autosomal form of KS, was performed and one splicing mutation (IVS14 + 1G > A) was identified
in one patient. 相似文献
90.
José Alexandre da Rocha Curvelo Anna Lea Silva Barreto Camila A. dos Anjos Rafaela S. Santana Ariadne Nunes Alonso Maria Teresa Vilela Romanos Kelly C. G. de Moura Paula Fernandes Carneiro Maristela Barbosa Portela Maria do Carmo F. R. Pinto Rosangela Maria de Araújo Soares 《Medicinal chemistry research》2015,24(3):1155-1161