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991.
Pol RA van Leeuwen BL Reijnen MM Zeebregts CJ 《Vascular medicine (London, England)》2012,17(2):116-122
Old and frail patients undergoing vascular surgery seem at great risk of developing postoperative delirium (POD). The aim of this review was to identify risk factors for the development of POD in vascular surgery patients. Different aetiological factors have been identified, such as increased age, excessive blood transfusion, preoperative cognitive impairment and depression. Mounting evidence supports a role for inflammation and tobacco exposure in the development of POD. Vascular surgery patients differ from the general surgical population because they suffer from both loco-regional and systemic atherosclerosis. Although current scientific evidence cannot fully link both entities, evidence is growing that suggests a relationship between systemic and cerebrovascular atherosclerosis and the development of POD. 相似文献
992.
Renato Pietro Ricci Carlo Pignalberi Barbara Magris Stefano Aquilani Vito Altamura Loredana Morichelli Antonio Porfili Laura Quarta Fabio Saputo Massimo Santini 《Journal of interventional cardiac electrophysiology》2012,33(1):113-121
Background
In 2007, great concern arose regarding failure of implantable cardioverter defibrillator (ICD) leads from several manufacturers. 相似文献993.
MA Weber J Basile M Stapff B Khan D Zhou 《Journal of clinical hypertension (Greenwich, Conn.)》2012,14(9):588-592
J Clin Hypertens (Greenwich). 2012; 14:588–592. © 2012 Wiley Periodicals, Inc. Blood pressure (BP) reductions when combining blockers of the renin‐angiotensin system (RAS) and β‐blockers have generally not been shown to be greater than for individual agents, possibly because of overlapping mechanisms of action. The authors tested the additivity of the β‐blocker nebivolol, which has vasodilating activity, with the angiotensin‐converting enzyme inhibitor lisinopril in patients with stage 2 diastolic hypertension. The BP effects of placebo (n=93), nebivolol 5 mg to 20 mg daily (n=185), lisinopril 10 mg to 40 mg daily (n=189), and nebivolol 5 mg to 20 mg + lisinopril 10 mg to 40 mg (n=189) during 6 weeks of treatment were compared. The primary end point was change in diastolic BP (DBP). For the full cohort, baseline BP was 163.8/104.4 mm Hg, mean age was 49.2 years, 58% were men, 62% were white, and 34% were black. DBP fell by 17.2±10.2 mm Hg with the combination, greater than placebo (8.0±9.2, P<.0001), nebivolol (13.3±8.9, P=.0010), and lisinopril (12.0±9.8, P<.0001). For systolic BP, corresponding reductions were 19.2±19.8 mm Hg, 9.9±16.4 (P<.0001 vs combination), 14.4±14.1 (P=.0470), and 16.1±17.2 (P=.0704). Adverse event rates were similar in all groups. This study demonstrated the potential antihypertensive benefits of combining nebivolol with a RAS blocker. 相似文献
994.
Christa?Kasang Albrecht?Ulmer Norbert?Donhauser Barbara?Schmidt August?Stich Hartwig?Klinker Samuel?Kalluvya Eleni?Koutsilieri Axel?Rethwilm Carsten?SchellerEmail author 《BMC infectious diseases》2012,12(1):14
Background
HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression. 相似文献995.
996.
Duloxetine (Cymbalta) is a potent serotonin norepinephrine reuptake inhibitor used for the management of major depression and pain associated with diabetic peripheral neuropathy. Cymbalta delayed-release capsules contain Duloxetine HCl equivalent to 20, 30, 60?mg of Duloxetine. The ingestion of high quantities of Duloxetine may have serious outcomes such as venous thrombosis, causing cardiac respiratory arrest. The Authors outline a case report of an elderly woman, suffering from depression, found dead in her apartment. The cause of death was attributed to acute massive pulmonary thromboembolism due to acute intoxication of Duloxetine bought the day before. The thesis supported by the authors and confirmed by the data from other studies is that a massive intake of Duloxetine drug increases considerably the medication's side effects such as somnolence, dry mouth, fatigue, insomnia, dizziness, constipation, considerable increases in recumbent systolic and diastolic blood pressure, and a small decrease in heart rate. 相似文献
997.
998.
Lai H Gerstenblith G Fishman EK Brinker J Kickler T Tong W Bhatia S Hong T Chen S Li J Detrick B Lai S 《Clinical infectious diseases》2012,54(12):1747-1755
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