全文获取类型
收费全文 | 6081篇 |
免费 | 456篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 263篇 |
妇产科学 | 100篇 |
基础医学 | 788篇 |
口腔科学 | 91篇 |
临床医学 | 536篇 |
内科学 | 1326篇 |
皮肤病学 | 176篇 |
神经病学 | 347篇 |
特种医学 | 258篇 |
外科学 | 648篇 |
综合类 | 387篇 |
一般理论 | 4篇 |
预防医学 | 371篇 |
眼科学 | 103篇 |
药学 | 452篇 |
中国医学 | 31篇 |
肿瘤学 | 591篇 |
出版年
2022年 | 69篇 |
2021年 | 125篇 |
2020年 | 71篇 |
2019年 | 100篇 |
2018年 | 132篇 |
2017年 | 83篇 |
2016年 | 127篇 |
2015年 | 133篇 |
2014年 | 181篇 |
2013年 | 261篇 |
2012年 | 360篇 |
2011年 | 355篇 |
2010年 | 228篇 |
2009年 | 201篇 |
2008年 | 289篇 |
2007年 | 340篇 |
2006年 | 230篇 |
2005年 | 204篇 |
2004年 | 203篇 |
2003年 | 190篇 |
2002年 | 156篇 |
2001年 | 171篇 |
2000年 | 173篇 |
1999年 | 171篇 |
1998年 | 115篇 |
1997年 | 98篇 |
1996年 | 80篇 |
1995年 | 70篇 |
1994年 | 79篇 |
1993年 | 72篇 |
1992年 | 124篇 |
1991年 | 89篇 |
1990年 | 90篇 |
1989年 | 133篇 |
1988年 | 73篇 |
1987年 | 87篇 |
1986年 | 66篇 |
1985年 | 63篇 |
1984年 | 43篇 |
1983年 | 34篇 |
1982年 | 37篇 |
1979年 | 29篇 |
1977年 | 48篇 |
1976年 | 32篇 |
1975年 | 30篇 |
1974年 | 34篇 |
1973年 | 45篇 |
1972年 | 38篇 |
1971年 | 31篇 |
1967年 | 36篇 |
排序方式: 共有6575条查询结果,搜索用时 15 毫秒
11.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
12.
The treatment of neoplasia with interleukin-2 (IL-2) can be complicated by neurological deficits resembling transient Ischemic attack and stroke. We investigated whether interleukin-2 contributes to the natural course of cerebrovascular ischemia and particularly to the pathogenesis of infection-associated stroke. Plasma levels of interleukin-2 were below the level of detectability in almost all measurements. Patients with and without previous infection (n = 11, 805 ±445 U/ml vs n = 19, 824 ± 501 U/ml) did not have significantly higher levels of soluble interleukin-2 receptors than control subjects with (n = 14, 667 ± 229 U/ml) or without vascular risk factors (n = 17, 567 ± 176 U/ml). Receptor levels increased in patients during the first week after stroke (n = 15, 1157 ± 1013, p < 0.02). Levels of soluble T8 antigen (sT8) were higher in patients (n – 26, 320 ± 112 U/ml) than in healthy control subjects (n = 15, 246 ± 92 U/ml; p < 0.05) and sT8 levels increased during the first week after stroke (p < 0.05). These results reflect an immunological response to the cerebral infarct; they do not indicate a general role of the IL-2 system in the pathogenesis of ischemic stroke with or without previous infection. 相似文献
13.
14.
15.
16.
17.
18.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
19.
Short term effect of diltiazem on portal hypertension in patients with non-cirrhotic portal fibrosis
S Banerjee S S Banerjee S Chakraborty P Mukherjee 《Indian journal of gastroenterology》1991,10(1):7-9
Fourteen patients of non-cirrhotic portal fibrosis (NCPF) with portal hypertension were put on oral diltiazem hydrochloride (90 mg/day) or placebo on a prospective, randomised, single blind basis for 15 days. Predrug hemodynamic and biochemical status were similar in both groups. Diltiazem produced significant reduction (p less than 0.001) in mean intrasplenic pressure: from 41.88 (SD +/- 6.18) to 21.5 (+/- 7.91) cm of normal saline as against 45.56 (+/- 9.45) to 43.33 (+/- 8.27) in the placebo group. Mean arterial pressure (MAP), heart rate and cardiac output (CO) did not change in either group. Thus, the calcium channel blocker diltiazem reduces portal pressure in patients with NCPF, independent of reduction in MAP and CO; this is advantageous in situations where compromised cardiac hemodynamics may prove deleterious. 相似文献
20.
Medial border of the perirenal space: CT and anatomic correlation 总被引:11,自引:0,他引:11