全文获取类型
收费全文 | 37095篇 |
免费 | 3534篇 |
国内免费 | 1340篇 |
专业分类
耳鼻咽喉 | 476篇 |
儿科学 | 1016篇 |
妇产科学 | 660篇 |
基础医学 | 3508篇 |
口腔科学 | 716篇 |
临床医学 | 4134篇 |
内科学 | 4614篇 |
皮肤病学 | 439篇 |
神经病学 | 2292篇 |
特种医学 | 1768篇 |
外科学 | 3779篇 |
综合类 | 6109篇 |
现状与发展 | 8篇 |
一般理论 | 21篇 |
预防医学 | 4170篇 |
眼科学 | 553篇 |
药学 | 3856篇 |
34篇 | |
中国医学 | 1999篇 |
肿瘤学 | 1817篇 |
出版年
2023年 | 351篇 |
2022年 | 741篇 |
2021年 | 1061篇 |
2020年 | 897篇 |
2019年 | 593篇 |
2018年 | 659篇 |
2017年 | 730篇 |
2016年 | 656篇 |
2015年 | 990篇 |
2014年 | 1269篇 |
2013年 | 1787篇 |
2012年 | 2681篇 |
2011年 | 2742篇 |
2010年 | 2347篇 |
2009年 | 1961篇 |
2008年 | 2362篇 |
2007年 | 2292篇 |
2006年 | 2132篇 |
2005年 | 1735篇 |
2004年 | 1354篇 |
2003年 | 1278篇 |
2002年 | 1007篇 |
2001年 | 1029篇 |
2000年 | 923篇 |
1999年 | 617篇 |
1998年 | 254篇 |
1997年 | 223篇 |
1996年 | 185篇 |
1995年 | 171篇 |
1994年 | 156篇 |
1993年 | 147篇 |
1992年 | 400篇 |
1991年 | 428篇 |
1990年 | 413篇 |
1989年 | 376篇 |
1988年 | 396篇 |
1987年 | 406篇 |
1986年 | 329篇 |
1985年 | 363篇 |
1984年 | 272篇 |
1983年 | 232篇 |
1982年 | 146篇 |
1979年 | 253篇 |
1978年 | 196篇 |
1976年 | 170篇 |
1974年 | 178篇 |
1973年 | 170篇 |
1972年 | 151篇 |
1969年 | 169篇 |
1968年 | 146篇 |
排序方式: 共有10000条查询结果,搜索用时 79 毫秒
21.
22.
23.
万东程控X线机透视电路分析与故障检修 总被引:1,自引:0,他引:1
本文就万东程控X线机一例特殊透视故障,系统分析了整机透视电路工作信号流程,并利用机器服务程序和各已知测量点波形综合分析、判断故障点。排除故障。讨论了在处理一些没有显示故障代码的情况下进行检修的一般思路。 相似文献
24.
Dr. Michael Gosland Pharm.D. Dr. Bert Lum Pharm.D. Dr. Julia Schimmelpfennig Pharm.D. Dr. James Baker Pharm.D. Dr Michael Doukas M.D. 《Pharmacotherapy》1996,16(1):16-39
Cisplatin in combination with other cytotoxic agents is the backbone for a potential cure of testicular germ cell neoplasms and is a critical factor in the substantial activity observed in the treatment of small cell lung cancer, bladder cancer, and ovarian germ cell tumors. Resistance to cisplatin at the onset of treatment or at relapse limits its curative potential, however. Laboratory studies using both cells selected for cisplatin resistance by exposure to sublethal concentrations and biopsy specimens from patients' tumors provide insights for the potential mechanisms of resistance. The mechanisms identified in vitro include a complex and wide array of related and unrelated pathways such as alterations in cellular drug transport, enhanced DNA repair dependent and independent of signal transduction pathways, and enhanced intracellular detoxification such as glutathione and metallothionein systems. Studies of these mechanisms have identified a number of agents with known potential for administration to humans and that reverse cisplatin resistance in vitro; for example, reversal of cellular accumulation defects by dipyridamole; inhibition of DNA repair by hydroxyurea, pentoxifylline, and novobiocin; inhibition of the glutathione system by ethacrynic acid and buthionine sulfoximine; and inhibition of signal transduction pathways by cyclosporine, tamoxifen, and calcium channel-blocking agents. Current phase I clinical trials are focusing on the most effective doses and schedules to administer these agents in combination with cisplatin. Initial uncontrolled trials in limited numbers of patients suggest that the addition of modulators of cisplatin has the potential to reverse resistance in patients previously failing therapy. Another promising avenue for circumventing cisplatin resistance is the development of noncross-resistant platinum analogs. 相似文献
25.
A. O. Azghani J. W. Baker S. Shetty E. J. Miller G. J. Bhat 《Inflammation research》2002,51(10):506-510
OBJECTIVE AND DESIGN: Bacterial products as well as the host airway inflammatory responses contribute to the pathogenesis of Pseudomonas infections. We sought to determine if Pseudomonas elastase (PE) induces mitogen-activated protein (MAP) kinase activity in association with interleukin-8 (IL-8) production by alveolar epithelial cells. METHODS: We utilized Western blot analysis to detect phosphorylation of signaling intermediates and ELISA was used to measure IL-8 production. RESULTS: We found that PE induces phosphorylation of the extracellular signal-regulated (ERK1/2) proteins of the MAPK pathway in A549 epithelial cells. Similar results were obtained using primary cultures of rabbit alveolar type II epithelial cells. PE also enhanced IL-8 production, which was abolished in the presence of the ERK activation inhibitor U0126. CONCLUSIONS: We conclude that PE activates the ERK1/2 arm of the MAPK pathway and that activation of this pathway results in enhanced IL-8 production. The results demonstrate that PE may augment pulmonary inflammation via cellular signaling that regulates expression of IL-8. 相似文献
26.
We undertook a prospective study using arthroscopy to determine the intraarticular derangement caused by initial anterior shoulder dislocations. Of our 32 patients, 15 (47%) had a grade I, grade II, or grade III Hill-Sachs lesion. The patients were 29 men and 3 women whose ages ranged from 15 to 28 years (mean 22 years). All of the patients studied were United States military personnel or members of their families. None of the patients had had prior injuries of the affected shoulder, and all underwent arthroscopy within 72 h of injury. Few reports describe a Hill-Sachs lesion in a patient following a single anterior dislocation. Early reports of this lesion were based on indirect (radiographic) evidence. Our arthroscopic findings indicate that the incidence of this lesion after one anterior dislocation is higher than previously thought. 相似文献
27.
报道了1,2-环己二胺异柠檬酸铂(Ⅱ)及1,2-环己二胺柠檬酸铂(Ⅱ)的合成及鉴定方法。抗癌试验表明前者在40及80mg/kg 剂量下对小鼠 L1210、P388及S180均有明显的抑瘤作用,且有部分动物可治愈;后者对 L1210也有明显的抑瘤作用,但较前者为弱。 相似文献
28.
80例健康青年分别经针刺或艾灸肺俞穴后的肺功能变化 总被引:3,自引:0,他引:3
目的:探讨针刺与艾灸肺俞穴对健康人肺功能的影响。方法:我们选择了20-22岁健康男性80例,随机分为针刺组和艾灸组各40例,于针刺,艾灸前和针刺,艾灸后10min测试用力肺活量(FVC),用力呼气量(FEV1.0),最大呼气中段流速(MMF),最大呼气流量(PEFR),75%,50%,25%肺活量时的最大呼气流速(V75,V50,V25),结果:显示经针刺和艾灸肺俞穴后2组FVC,FFV1.0均显著增加,P<0.05,2组间比较针刺组FVC明显高于艾灸组,P<0.05,而且艾灸组MMF,V25亦显著降低P<0.05,结论:健康人经针刺和艾灸肺俞穴后均可使大气道阻力减少,肺容量增加,提示一定量的艾燃烧后的烟雾可使健康人肺功能受到影响,使肺的小气道收缩,出现阻塞性改变。 相似文献
29.
①目的 探讨血管紧张素转换酶 (ACE)基因的插入 缺失 (I D)多态性与肺源性心脏病 (肺心病 )的关系。②方法 选取肺心病病人 63例 ,正常对照组 40例。常规制备外周血白细胞DNA ,采用多聚酶链反应 (PCR)检测两组人群ACE基因的I D多态性。③结果 肺心病组和正常对照组均检测到ACE基因的II,ID及DD 3种基因型 ,肺心病组 3种基因型的频率分别为 0 .45 ,0 .41和 0 .1 4 ,正常对照组为 0 .42 ,0 .41和 0 .1 7,两组比较差异无显著性 (χ2 =2 .1 57,P >0 .0 5) ;两组I,D等位基因频率分别为 0 .54 ,0 .46和 0 .61 ,0 .39,两组间比较差异无显著性(χ2 =1 .2 57,P >0 .0 5)。④结论 ACE基因I D多态性与肺心病发生无明显相关性 相似文献
30.
目的了解大学生核黄素营养状况,并探讨其影响因素。方法对护理、预防专业的学生进行核黄素4h负荷尿试验,用荧光光度法测定核黄素含量。结果护理学专业的学生核黄素不足的占78.79%,正常占10.10%,充裕的占11.31%。预防医学专业的学生核黄素不足的占74.42%,正常的占16.28%,充裕的占9.3%。专业之间差异无显著性意义(P〉0.05)。结论大学生的核黄素营养水平普遍较低,其中动物性食品摄人较少、学生对合理膳食的营养知识缺乏是核黄素摄人不足的主要原因。 相似文献