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991.
The foraging and predator-avoidance behaviors of mayfly (Baetis tricaudatus) nymphs and predator-prey interactions were investigated under differing combinations of cadmium concentration and predation risk. Predators consisted of stonefly (Kogotus nonus) nymphs, juvenile brook trout (Salvelinus fontinalis), and longnose dace (Rhinichthys cataractae), either alone or in combination. Organisms were exposed to 0, 0.5, or 5.0 microg/L Cd for 7 d (invertebrates) or 30 d (vertebrates) prior to observation in artificial stream channels. Behavioral observations (20-min duration) were made both day and night over a 24-h period. Mayfly feeding rate was assessed by image analysis of grazed diatom mats cultured on ceramic tiles. Both predators and cadmium produced significant effects on the behavior of B. tricaudatus and K. nonus nymphs, with mayflies showing a hierarchical response in the presence of multiple predators. A significant increase in activity was observed in S. fontinalis exposed to 5.0 microg/L Cd, with significant decreases in capture efficiency of prey items apparent at 0.5 microg/L Cd. Conversely, the foraging behavior of R. cataractae was unaffected by cadmium, possibly as a result of species-specific cadmium tolerance. Such sublethal effects of a contaminant on the energy budgets of individuals and the interactions between species have implications for community structure in aquatic food webs. 相似文献
992.
Prey choice in juvenile brook trout (Salvelinus fontinalis) was investigated under sublethal Cd stress in the presence of alternative prey types. Following 30-d exposures to either 0, 0.5, or 5.0 microg/L Cd, individual fish held in artificial stream channels were presented with both motile (Baetis tricaudatus) and nonmotile (Chironomus tentans) prey items and their foraging behavior and capture success was observed. The Cd-exposed trout were found to express a significant preference for C. tentans larvae as alternative prey to B. tricaudatus nymphs. Nevertheless, these preliminary findings indicate that, irrespective of prey choice, the capture efficiency of Cd-stressed trout declined by 20 to 55% with increasing Cd concentration when compared with control fish, and the activity of individual trout increased by 25% over controls, although these responses were not statistically significant. Cadmium significantly affected fish condition factors: The condition factor of control fish increased by 34% over the 30-d period, and Cd-exposed fish declined in condition by 12 to 18%. It is hypothesized that such a switch by fish to feeding on benthic prey under natural exposure conditions and their proximity to contaminated sediment may further exacerbate the sublethal effects of Cd on these individuals by intensifying or prolonging Cd exposure through a combination of trophic transfer and altered foraging behavior. 相似文献
993.
994.
Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis 总被引:4,自引:0,他引:4 下载免费PDF全文
Rhee CS Libet L Chisholm D Takabayashi K Baird S Bigby TD Lee CH Horner AA Raz E 《Immunology》2004,113(1):106-113
While effective for the prevention and treatment of allergic rhinitis (AR) symptoms, currently available medications do not reverse allergen specific hypersensitivities. Therefore, pharmacotherapeutics are not curative and their daily use is often required for years. These investigations were conducted to determine whether immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) delivery protects previously sensitized mice from AR hypersensitivity responses and modulates their allergen specific immune profiles. Mice were first sensitized with ovalbumin (OVA) and alum, twenty-four hr before beginning a series of seven daily intranasal (i.n.) allergen challenges, subsets of mice received a single i.n. or intradermal (i.d.) dose of ISS-ODN or control oligodeoxynucleotide (C-ODN), a single intraperitoneal (i.p.) injection of dexamethasone (DXM), or no intervention. Mice receiving i.d. or i.n. ISS-ODN were found to have attenuated immediate and late phase effector cell responses to i.n. OVA challenge. Specifically, ISS-ODN treated mice had less histamine and cysteinyl leukotriene release and eosinophilic inflammation in their nasal passages than mice treated with C-ODN. In addition, splenocytes from ISS-ODN but not C-ODN treated mice displayed attenuated OVA-specific interleukin (IL)-4, IL-5, and IL-13 but increased interferon-gamma responses. Finally, ISS-ODN was generally a more effective treatment than DXM, both in blunting AR hypersensitivity responses and in shifting T helper 2 Th2-biased immune parameters towards Th1 dominance. As ISS-ODN delivery rapidly attenuated effector cell responses in this AR model in an allergen independent manner, the present results suggest that therapy with ISS-ODN alone may be an effective alternative to corticosteroid medications for the clinical management of AR. 相似文献
995.
Young SL Simon MA Baird MA Tannock GW Bibiloni R Spencely K Lane JM Fitzharris P Crane J Town I Addo-Yobo E Murray CS Woodcock A 《Clinical and diagnostic laboratory immunology》2004,11(4):686-690
The gut microbiota may be important in the postnatal development of the immune system and hence may influence the prevalence of atopic diseases. Bifidobacteria are the most numerous bacteria in the guts of infants, and the presence or absence of certain species could be important in determining the geographic incidence of atopic diseases. We compared the fecal populations of bifidobacteria from children aged 25 to 35 days in Ghana (which has a low prevalence of atopy), New Zealand, and the United Kingdom (high-prevalence countries). Natal origin influenced the detection of bifidobacterial species in that fecal samples from Ghana almost all contained Bifidobacterium infantis whereas those of the other children did not. Choosing species on the basis of our bacteriological results, we tested bifidobacterial preparations for their effects on cell surface markers and cytokine production by dendritic cells harvested from cord blood. Species-specific effects on the expression of the dendritic-cell activation marker CD83 and the production of interleukin-10 (IL-10) were observed. Whereas CD83 expression was increased and IL-10 production was induced by Bifidobacterium bifidum, Bifidobacterium longum, and Bifidobacterium pseudocatenulatum, B. infantis failed to produce these effects. We concluded that B. infantis does not trigger the activation of dendritic cells to the degree necessary to initiate an immune response but that B. bifidum, B. longum, and B. pseudocatenulatum induce a Th2-driven immune response. A hypothesis is presented to link our observations to the prevalence of atopic diseases in different countries. 相似文献
996.
997.
D?Anil?Kumar RN?Suresh?Kumar PN?Rao S?Chandran H?Mahmoud AS?Pillay DK?Saxena CG?Venkitachalam T?Cartmill IM?RaoEmail author 《Indian Journal of Thoracic and Cardiovascular Surgery》2003,19(4):159-162
Background The major strategy for palliation of cyanotic lesions in neonates is the systemic to pulmonary arterial shunt.
Methods Between May 1995, and December 2002, 48 consecutive neonates underwent systemic to pulmonary arterial shunts for cyanosis
with reduced pulmonary blood flow. The mean age was 11.6 days (±SD 7.38) and the mean weight, 3.2kg (±SD 0.52). The babies
were classified into three groups: Group I-Tetralogy-pulmonary Atresia (n=18), Group II-single Ventricle-Pulmonary atresia
without (n=19) and with (n=5) isomerism, Group III-Pulmonary Atresia with Intact ventricular septum (n=6). Diagnosis was made
by 2D echocardiography. Indication for cardiac catheterization was delineation of pulmonary anatomy/ductus laterality (n=4)
or balloon atrial septostomy (n=4). The surgical procedure was a modified Blalock-Taussig shunt on the side of the situs.
Post-operatively, no anti-coagulation or anti-platelet medication was employed.
Results There was no mortality. Four cases required revision of the shunt in the immediate post-operative period for shunt thrombosis.
The mean follow up was 17.54 months (±SD 8.36). In Group I, nine patients have undergone total correction with or without
a conduit, while three required new arterial shunts for shunt/pulmonary artery stenosis. In Group II, nine patients have undergone
bi-directional Glenn with atrial septectomy (n=2) and pulmonary artery plasty (n=4) and one patient underwent Fontan completion.
In Group III, two patients underwent bi-directional Glenn and two had pulmonary valvotomy with/without right ventricular outflow
tract widening. All the remaining babies are waiting for the second/final stage palliation or total correction.
Conclusion Systemic to pulmonary arterial shunts in neonates is a gratifying and reasonably safe surgical procedure. Most babies become
candidates for eventual univentricular/bi-ventricular repair. 相似文献
998.
999.
Cancilla DA Baird JC Geis SW Corsi SR 《Environmental toxicology and chemistry / SETAC》2003,22(1):134-140
This paper presents the results of a number of field and laboratory studies to evaluate the environmental impact of aircraft deicing and anti-icing fluids (ADAFs) on aquatic systems. Both 5-methyl-1H-benzotriazole (5-MeBt) and 4-methyl-1H-benzotriazole (4-MeBt), known additives to ADAFs, were found in whole-tissue extracts from minnows placed downstream of an effluent outfall that receives ADAF contaminated runoff from General Mitchell International Airport (Milwaukee, WI, USA). Neither of these compounds was detected in tissues from minnows placed upstream from the airport. A toxicity assessment of water collected during the minnow exposure studies utilizing Hyalella azteca, Pimephales promelas, and Ceriodaphnia dubia showed greater toxicity in a secondary airport outfall containing ADAFs when compared to upstream non-ADAF-contaminated samples. In two 28-d static renewal tests using 5-MeBt laboratory-fortified waters, 5-MeBt was detected in whole-tissue extracts of minnows at all concentrations tested. In studies using laboratory water fortified with 5-MeBt, the median lethal concentration (LC50) of 5-MeBt for P. promelas was found to be 22.0 mg/L. The LC50 for C. dubia to 5-MeBt laboratory-fortified water was found to be 81.3 mg/L. The 25% inhibition concentration (IC25) of 5-MeBt for the green alga Selenastrum capricornutum was 23.2 mg/L, and the average median effective concentration (EC50) for Microtox was 4.25 mg/L. The results of these field and lab studies indicate that additives, other than glycols, used in aircraft deicing fluids can be found in aquatic systems and may be of greater risk than previously believed. 相似文献
1000.