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151.
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153.
A recently derived in vitro chemiluminescence assay (Salles et al. [1995]
Anal. Biochem., 232, 37-42) has been used to investigate the effects of a
panel of twenty-two anticancer drugs and certain antibiotics on the
excision repair activity of cell-free extracts from the human cell line,
HeLa. This methodology, termed the 3D (Damaged DNA Detection) assay, based
on the in vitro excision repair assay previously developed (Wood et al.
[1988] Cell, 53, 97-106) has provided data indicating definite in vitro
inhibition of DNA repair by actinomycin D, aphidicolin, doxorubicin,
distamycin A and mithramycin A. This assay therefore offers the potential
for identifying agents with the ability to inhibit DNA repair.
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A Mauskop BT Altura RQ Cracco BM Altura 《Cephalalgia : an international journal of headache》1994,14(1):24-28
The entity of chronic daily headache (CDH) is well documented, but is not included in the current classification. We divided patients with CDH into groups with and without migrainous features. This division resulted in clearly distinguishable syndromes of daily migrainous headaches (DMH) and daily tension-type headaches (DTH). Family history of headaches was more common in patients with DMH. Patients in both groups had a high incidence of caffeine or drug overuse. The clinical division into DMH and DTH was supported by our finding of a higher incidence of disturbed magnesium (Mg) metabolism in patients with DMH. Of 26 patients with DMH, 8 (30.8%) had low serum ionized, but not total, Mg levels, and 16 (61.5%) had high ionized calcium/magnesium ratios. The corresponding numbers for the 22 patients with DTH were 1 (4.5%) and 8 (30.4%). These new laboratory measurements offer possible biological markers for the diagnosis of different headache syndromes. 相似文献
156.
The Summer Geriatric Extern Program was developed in 2004 to provide nursing students between the junior and senior year an opportunity to learn more about careers in geriatric nursing.This full-time, eight-week commitment provides students with a stipend and a faculty mentor in their area of interest. Of the 24 externs since the inception of the program, seven have enrolled in graduate programs. The findings suggest that the summer geriatric externship program is effective in developing interest in a geriatric nursing career and providing exposure to nursing research and other aspects of the faculty role. 相似文献