全文获取类型
收费全文 | 3087篇 |
免费 | 209篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 92篇 |
妇产科学 | 34篇 |
基础医学 | 360篇 |
口腔科学 | 47篇 |
临床医学 | 257篇 |
内科学 | 664篇 |
皮肤病学 | 46篇 |
神经病学 | 199篇 |
特种医学 | 294篇 |
外科学 | 307篇 |
综合类 | 106篇 |
一般理论 | 4篇 |
预防医学 | 196篇 |
眼科学 | 163篇 |
药学 | 236篇 |
中国医学 | 7篇 |
肿瘤学 | 330篇 |
出版年
2023年 | 14篇 |
2022年 | 13篇 |
2021年 | 71篇 |
2020年 | 32篇 |
2019年 | 54篇 |
2018年 | 52篇 |
2017年 | 56篇 |
2016年 | 48篇 |
2015年 | 57篇 |
2014年 | 89篇 |
2013年 | 122篇 |
2012年 | 128篇 |
2011年 | 171篇 |
2010年 | 96篇 |
2009年 | 99篇 |
2008年 | 127篇 |
2007年 | 168篇 |
2006年 | 127篇 |
2005年 | 169篇 |
2004年 | 144篇 |
2003年 | 139篇 |
2002年 | 112篇 |
2001年 | 134篇 |
2000年 | 80篇 |
1999年 | 77篇 |
1998年 | 69篇 |
1997年 | 86篇 |
1996年 | 75篇 |
1995年 | 67篇 |
1994年 | 48篇 |
1993年 | 52篇 |
1992年 | 43篇 |
1991年 | 49篇 |
1990年 | 32篇 |
1989年 | 70篇 |
1988年 | 56篇 |
1987年 | 51篇 |
1986年 | 39篇 |
1985年 | 35篇 |
1984年 | 24篇 |
1983年 | 14篇 |
1982年 | 22篇 |
1981年 | 29篇 |
1980年 | 23篇 |
1979年 | 23篇 |
1978年 | 12篇 |
1977年 | 19篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1970年 | 5篇 |
排序方式: 共有3370条查询结果,搜索用时 15 毫秒
101.
102.
Introduction
Traumatic tendon lacerations are a common problem encountered by hand surgeons worldwide. Although the use of barbed suture to repair tendon lacerations has gained theoretical popularity in recent years, there is little information available regarding the safety, efficacy, longevity, or complications encountered when used in tenorraphy. In this study, we review the available literature on the use of barbed suture in tendon repair.Methods
Studies conducted between 1980 and 2014 were identified using several databases, including EMBASE, SCOPUS, MEDLINE, and Web of Science. Keywords used to search for appropriate studies included the following: barbed, v loc, quill, tendon, tendon injuries, suture, tenorraphy, injury, and laceration, in various combinations.Results
Our initial literature search identified 47 articles, and 8 were deemed appropriate for review after applying our exclusion criteria. The data from each of the articles is reviewed for the following major categories:- Maximum load to failure
- Mode of failure
- Load to 2-mm gap
- Change in cross-sectional area
- Type of repair
Conclusions
Barbed suture tenorraphy has a myriad of theoretical advantages, supported by varying ex vivo studies, as compared to traditional techniques. However, due to the non-uniformity in current studies and the lack of available data in a live model, we are unable to argue for or against barbed suture tenorraphy. We believe our review provides the most in-depth analysis of barbed suture tenorraphy to date, illuminates the potential advantages of using barbed sutures, and highlights the need for further investigation into this technique. 相似文献103.
Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V 总被引:6,自引:1,他引:6
Gln506-factor V (FV) was purified from plasma of an individual homozygous for an Arg506Gln mutation in FV that is associated with activated protein C (APC) resistance. Purified Gln506-FV, as well as Gln506-FVa generated by either thrombin or FXa, conveyed APC resistance to FV-deficient plasma in coagulation assays. Clotting assay studies also suggested that APC resistance does not involve any abnormality in FV-APC-cofactor activity. In purified reaction mixtures, Gln506-FVa in comparison to normal FVa showed reduced susceptibility to APC, because it was inactivated approximately 10-fold slower than normal Arg506-FVa. It was previously reported that inactivation of normal FVa by APC involves an initial cleavage at Arg506 followed by phospholipid- dependent cleavage at Arg306. Immunoblot and amino acid sequence analyses showed that the 102-kD heavy chain of Gln506-FVa was cleaved at Arg306 during inactivation by APC in a phospholipid-dependent reaction. This reduced but measurable susceptibility of Gln506-FVa to APC inactivation may help explain why APC resistance is a mild risk factor for thrombosis because APC can inactivate both normal FVa and variant Gln506-FVa. In summary, this study shows that purified Gln506- FV can account for APC resistance of plasma because Gln506-FVa, whether generated by thrombin or FXa, is relatively resistant to APC. 相似文献
104.
105.
S. M. Bellemore E. Nikoopour B. C. Y. Au O. Krougly E. Lee‐Chan S. M. Haeryfar B. Singh 《Clinical and experimental immunology》2014,177(3):732-742
Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipoprotein E (ApoE)‐derived self‐peptide termed Ep1.B. We also showed that this C‐terminal region 239–252 peptide of ApoE has strong anti‐atherogenic activity and reduces neointimal hyperplasia after vascular surgery in rats and wild‐type as well as ApoE‐deficient mice. In this study, we explored the phenotype of DC subset induced by Ep1.B from monocytic cell lines and from the bone marrow‐derived cells. We found Ep1.B treatment induced cells that showed characteristics of plasmacytoid dendritic cells (pDC). We explored in‐vitro and in‐vivo effects of Ep1.B‐induced DCs on antigen‐specific T cell responses. Upon in‐vivo injection of these cells with antigen, the subsequent ex‐vivo antigen‐specific proliferation of lymph node cells and splenocytes from recipient mice was greatly reduced. Our results suggest that Ep1.B‐induced pDCs promote the generation of Treg cells, and these cells contribute to the induction of peripheral tolerance in adaptive immunity and potentially contribute its anti‐atherogenic activity. 相似文献
106.
Michinori Ogura Kiyoshi Ando Tatsuya Suzuki Kenichi Ishizawa Sung Yong Oh Kuniaki Itoh Kazuhito Yamamoto Wing Yan Au Hwei‐Fang Tien Yoshihiro Matsuno Takashi Terauchi Keiko Yamamoto Masahiko Mori Yoshinobu Tanaka Takashi Shimamoto Kensei Tobinai Won Seog Kim 《British journal of haematology》2014,165(6):768-776
Although initial rituximab‐containing chemotherapies achieve high response rates, indolent B‐cell non‐Hodgkin lymphoma (B‐NHL), such as follicular lymphoma (FL), is still incurable. Therefore, new effective agents with novel mechanisms are anticipated. In this multicentre phase II study, patients with relapsed/refractory indolent B‐NHL and mantle cell lymphoma (MCL) received vorinostat 200 mg twice daily for 14 consecutive days in a 21‐d cycle until disease progression or unacceptable toxicity occurred. The primary endpoint was overall response rate (ORR) in FL patients and safety and tolerability in all patients. Secondary endpoints included progression‐free survival (PFS). Fifty‐six eligible patients were enrolled; 50 patients (39 with FL, seven with other B‐NHL, and four with MCL) were evaluable for ORR, and 40 patients had received rituximab‐containing prior chemotherapeutic regimens. For the 39 patients with FL, the ORR was 49% [95% confidence interval (CI): 32·4, 65·2] and the median PFS was 20 months (95% CI: 11·2, 29·7). Major toxicities were manageable grade 3/4 thrombocytopenia and neutropenia. Vorinostat offers sustained antitumour activity in patients with relapsed or refractory FL with an acceptable safety profile. Further investigation of vorinostat for clinical efficacy is warranted. 相似文献
107.
Fu‐Chun Zhou MD PhD Yu‐Tao Xiang MD PhD Chuan‐Yue Wang MD PhD Faith Dickerson PhD Julie Kreyenbuhl PharmD PhD Gabor S. Ungvari MD PhD Raymond W. C. Au PhD Jing‐Jing Zhou MPhil Yan Zhou BA David Shum PhD David Man PhD Kelly Y. C. Lai MRCPsy Wai‐Kwong Tang MRCPsy Xin Yu MD Helen F. K. Chiu FRCPsy 《Perspectives in psychiatric care》2014,50(2):102-110
108.
Gianetti E Hall JE Au MG Kaiser UB Quinton R Stewart JA Metzger DL Pitteloud N Mericq V Merino PM Levitsky LL Izatt L Lang-Muritano M Fujimoto VY Dluhy RG Chase ML Crowley WF Plummer L Seminara SB 《The Journal of clinical endocrinology and metabolism》2012,97(9):E1798-E1807
Context: A broad spectrum of GnRH-deficient phenotypes has been identified in individuals with both mono- and biallelic GNRHR mutations. Objective: The objective of the study was to determine the correlation between the severity of the reproductive phenotype(s) and the number and functional severity of rare sequence variants in GNRHR. Subjects: Eight hundred sixty-three probands with different forms of GnRH deficiency, 46 family members and 422 controls were screened for GNRHR mutations. The 70 subjects (32 patients and 38 family members) harboring mutations were divided into four groups (G1-G4) based on the functional severity of the mutations (complete or partial loss of function) and the number of affected alleles (monoallelic or biallelic) with mutations, and these classes were mapped on their clinical phenotypes. Results: The prevalence of heterozygous rare sequence variants in GNRHR was significantly higher in probands vs. controls (P < 0.01). Among the G1-G3 groups (homozygous subjects with successively decreasing severity and number of mutations), the hypogonadotropic phenotype related to their genetic load. In contrast, subjects in G4, with only monoallelic mutations, demonstrated a greater diversity of clinical phenotypes. Conclusions: In patients with GnRH deficiency and biallelic mutations in GNRHR, genetic burden defined by severity and dose is associated with clinical phenotype. In contrast, for patients with monoallelic GNRHR mutations this correlation does not hold. Taken together, these data indicate that as-yet-unidentified genetic and/or environmental factors may combine with singly mutated GNRHR alleles to produce reproductive phenotypes. 相似文献
109.
110.