High resolution copy number analysis of IRF4 translocation‐positive diffuse large B‐cell and follicular lymphomas

Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B‐cell‐derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array‐comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin‐fixed paraffin‐embedded and two fresh‐frozen IRF4 translocation‐positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3‐qter, and 7q32.1‐qter and losses in 6q13‐16.1, 15q14‐22.31, and 17p. No recurrent copy‐neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation‐positive lymphomas. © 2012 Wiley Periodicals, Inc.     

Separation and loss through immigration of African Caribbean women to the UK

Abstract

This paper reports on 20 women born in the Caribbean whose birth mothers left them there as young children in the care of grandmothers or other members of their extended family. This was in order to migrate to Great Britain during the late 1950s through the 1970s in search of economic prosperity, and reunification with the father/husband already working in the UK. The reunions occurred typically more than a decade later, in the child's adolescence, when mother and child were meeting as if for the first time. The sample of women was divided into two groups, one who was receiving or had received counselling or psychotherapy, and those who had no experience of therapy. Using a semi-structured Interview Schedule (the Separation Reunion Interview Schedule developed for this study), the narratives obtained suggested coherence and reflection. There was little difference in the reactions to the separation – reunion experience of the women in both groups. They all expressed difficulties in trusting others. They also expressed longing to be loved by their own mothers and they felt less wanted than any children (siblings) born in Britain to their mothers. They attributed their resilient stance and survival to their ability to recall the memories of care received during their early years. The study raises many questions and highlights the need for further research on broken attachments, separation, and loss among entire Caribbean families.     

Improvements in knee biomechanics during walking are associated with increased physical activity after total knee arthroplasty

Total knee arthroplasty (TKA) in people with knee osteoarthritis increases knee‐specific and general physical function, but it has not been established if there is a relationship between changes in these elements of functional ability. This study investigated changes and relationships between knee biomechanics during walking, physical activity, and use of time after TKA. Fifteen people awaiting TKA underwent 3D gait analysis before and six months after surgery. Physical activity and use of time were determined in free‐living conditions from a high resolution 24‐h activity recall. After surgery, participants displayed significant improvements in sagittal plane knee biomechanics and improved their physical activity profiles, standing for 105 more minutes (p = 0.001) and performing 64 min more inside chores on average per day (p = 0.008). Changes in sagittal plane knee range of motion (ROM) and peak knee flexion positively correlated with changes in total daily energy expenditure, time spent undertaking moderate to vigorous physical activity, inside chores and passive transport (r = 0.52–0.66, p = 0.005–0.047). Restoration of knee function occurs in parallel and is associated with improvements in physical activity and use of time after TKA. Increased functional knee ROM is required to support improvements in total and context specific physical activity. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1818–1825, 2015.     

Accessory mitral valve leaflet causing aortic regurgitation and left ventricular outflow tract obstruction. Case report and review of published reports

Arrhythmias, aortic regurgitation, and symptoms of severe intermittent ventricular outflow obstruction developed in a 14 year old boy with a heart murmur who had been followed from infancy. These were caused by an accessory mitral leaflet, which was successfully removed at open heart operation. A review of 21 previously reported cases found a high incidence of associated cardiac malformations, appreciable subaortic obstruction in most patients, and a consistent attachment of the accessory tissue to the ventricular aspect of the anterior mitral leaflet. The characteristic echocardiographic appearance of a mobile mass arising from the area of aortic-mitral continuity is sufficient for the diagnosis of accessory mitral leaflet and echocardiographic examination will facilitate the surgical management of this condition.     

Longitudinal correlations between MRE,MRI-PDFF,and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib

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A Three‐wave Study of Antecedents of Work–Family Enrichment: The Roles of Social Resources and Affect

On the basis of conservation of resources theory (Hobfoll, 1989 ) and the resource‐gain‐development perspective (Wayne, Grzywacz, Carlson, & Kacmar, 2007 ), this paper examines the differential impact of specific social resources (supervisory support and family support) on specific types of affect (job satisfaction and family satisfaction, respectively), which, in turn, influence work‐to‐family enrichment and family‐to‐work enrichment, respectively. A sample of 276 Chinese workers completed questionnaires in a three‐wave survey. The model was tested with structural equation modelling. Job satisfaction at time 2 partially mediated the relationship between time 1 supervisory support and time 3 work‐to‐family enrichment (capital), and the effect of supervisory support on work‐to‐family enrichment (affect) was fully mediated by job satisfaction. Family satisfaction at time 2 fully mediated the relationship between time 1 family support and time 3 family‐to‐work enrichment (affect, efficiency). Implications for theory, practice and future research are discussed. Copyright © 2013 John Wiley & Sons, Ltd.