Obesity, diabetes and OSAS induce of sleep disorders: Exercise as therapy

Sleep is an integral part of good health. Sleep disorders and variations in sleep habits are associated with a low-grade inflammatory status, which may be either a cause or consequence of other conditions, including obesity, diabetes and cardiovascular disease. Several strategies are available to counteract these conditions including continuous positive airway pressure (CPAP), pharmacological and nutritional interventions, and even surgery. At present, our group is investigating the effect of chronic endurance exercise on sleep alterations.     

Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients

We present a cross-sectional analysis of the maturation and migratory properties of the memory CD8(+) T cell compartment, in relation to the severity of heart disease in individuals with chronic Trypanosoma cruzi infection removed from endemic areas for longer than 20 years. Subjects with none or mild heart involvement were more likely to mount T. cruzi-specific memory IFN-gamma responses than subjects with more advanced cardiac disease, and the T. cruzi-specific CD8(+) T cell population was enriched in early-differentiated (CD27(+)CD28(+)) cells in responding individuals. In contrast, the frequency of CD27(+)CD28(+)CD8(+) T cells in the total memory CD8(+) T cell population decreases, as disease becomes more severe, while the proportion of fully differentiated memory (CD27(-)CD28(-)) CD8(+) T cells increases. The analysis of CCR7 expression revealed a significant increase in total effector/memory CD8(+) T cells (CD45RA(-)CCR7(-)) in subjects with mild heart disease as compared with uninfected controls. Altogether, these results are consistent with the hypothesis of a gradual clonal exhaustion in the CD8(+) T cell population, perhaps as a result of continuous antigenic stimulation by persistent parasites.     

新型超声导管体外消融血栓

目的探讨新型超声导管体外消融血栓的可行性和疗效。方法体外制备人全血细胞血栓54份并分成三组,应用传统球型（Ⅰ型）和新的球部顶端平截面型（Ⅱ型）及前方带缺口球型（Ⅲ型）三种不同头端的低频高能超声导管,体外对全血细胞血栓块行超声消融60s,比较消融前后固体血栓称重及融栓后上清液血栓碎片和红细胞直径。结果不同头端超声导管均可明显消融血栓,消融前后固体血栓称重差异比有显著意义（P〈0．01）,Ⅲ型和Ⅰ型组明显优于Ⅱ型组（P〈0．05）;显微镜下90％血栓碎片直径小于红细胞。结论体外低频高能超声可消融血栓,头端形状对血栓超声消融能力有明显的影响。