全文获取类型
收费全文 | 3096篇 |
免费 | 301篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 84篇 |
妇产科学 | 39篇 |
基础医学 | 302篇 |
口腔科学 | 241篇 |
临床医学 | 323篇 |
内科学 | 658篇 |
皮肤病学 | 139篇 |
神经病学 | 171篇 |
特种医学 | 182篇 |
外科学 | 492篇 |
综合类 | 95篇 |
现状与发展 | 30篇 |
预防医学 | 235篇 |
眼科学 | 24篇 |
药学 | 242篇 |
中国医学 | 14篇 |
肿瘤学 | 105篇 |
出版年
2024年 | 14篇 |
2023年 | 190篇 |
2022年 | 38篇 |
2021年 | 76篇 |
2020年 | 116篇 |
2019年 | 78篇 |
2018年 | 109篇 |
2017年 | 96篇 |
2016年 | 102篇 |
2015年 | 100篇 |
2014年 | 149篇 |
2013年 | 164篇 |
2012年 | 174篇 |
2011年 | 186篇 |
2010年 | 156篇 |
2009年 | 147篇 |
2008年 | 147篇 |
2007年 | 172篇 |
2006年 | 117篇 |
2005年 | 99篇 |
2004年 | 85篇 |
2003年 | 77篇 |
2002年 | 58篇 |
2001年 | 61篇 |
2000年 | 62篇 |
1999年 | 73篇 |
1998年 | 44篇 |
1997年 | 57篇 |
1996年 | 48篇 |
1995年 | 39篇 |
1994年 | 39篇 |
1993年 | 38篇 |
1992年 | 23篇 |
1991年 | 24篇 |
1990年 | 22篇 |
1989年 | 35篇 |
1988年 | 26篇 |
1987年 | 26篇 |
1985年 | 18篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 11篇 |
1981年 | 12篇 |
1980年 | 17篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1977年 | 8篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 8篇 |
排序方式: 共有3424条查询结果,搜索用时 468 毫秒
51.
Roxana Cristina Rimbaş Sorina Mihăilă Baldea Ruxandra Drăgoi Galrinho Antunes Guerra Simona Ionela Visoiu Mihai Rimbaş Corina Silvia Pop Dragoş Vinereanu 《Ultrasound in medicine & biology》2018,44(3):562-574
There are no clear recommendations regarding cirrhotic cardiomyopathy (CC) evaluation in patients with pre-transplant liver cirrhosis. The roles of new methods, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) in the diagnosis and prognosis of cirrhotic cardiomyopathy remain controversial. We investigated the utility of TDI/STE parameters in cirrhotic cardiomyopathy diagnosis and also in predicting mortality in patients with liver cirrhosis. Left/right ventricular function was studied using conventional TDI (velocities) and STE (strain/strain rate). We assessed left ventricular diastolic dysfunction, graded into four new classes (I/Ia/II/III). Serum NTproBNP (N-terminal prohormone of brain natriuretic peptide), troponin I, β-crosslaps, QTc interval, arterial compliance and endothelial function were measured. Liver-specific scores (Child–Pugh, MELD, MELDNa) were computed. There was a 1-y follow-up visit to determine mortality. We observed resting biventricular diastolic myocardial dysfunction, not presently included in the definition of cirrhotic cardiomyopathy. We provided an improved characterization of cardiac dysfunction in patients with liver cirrhosis. This might change the current definition. However, the utility of STE/TDI parameters in predicting long-term mortality in patients with liver cirrhosis remains controversial. 相似文献
52.
Penelas Alice Gonçalves da Silva Eduardo Moreira Fedozzi Julia Mattos Alves Amanda Cypriano Orem Paulo Roberto Barros Poskus Laiza Tatiana Feitosa Victor Pinheiro Guimarães José Guilherme Antunes 《Odontology / the Society of the Nippon Dental University》2022,110(3):569-576
Odontology - This study aimed at evaluating the influence of glass-fiber post (GFP) relining with composites of different opacities on resin cement layer thickness (CLT), bond strength (BS) to root... 相似文献
53.
ECG‐gated pulmonary artery CTA for evaluation of right ventricular function in patients with acute pulmonary embolism 下载免费PDF全文
54.
55.
Luísa C. S. Antunes Francesco Imperi Fabrizia Minandri Paolo Visca 《Antimicrobial agents and chemotherapy》2012,56(11):5961-5970
Multidrug-resistant Acinetobacter baumannii poses a tremendous challenge to traditional antibiotic therapy. Due to the crucial role of iron in bacterial physiology and pathogenicity, we investigated iron metabolism as a possible target for anti-A. baumannii chemotherapy using gallium as an iron mimetic. Due to chemical similarity, gallium competes with iron for binding to several redox enzymes, thereby interfering with a number of essential biological reactions. We found that Ga(NO3)3, the active component of an FDA-approved drug (Ganite), inhibits the growth of a collection of 58 A. baumannii strains in both chemically defined medium and human serum, at concentrations ranging from 2 to 80 μM and from 4 to 64 μM, respectively. Ga(NO3)3 delayed the entry of A. baumannii into the exponential phase and drastically reduced bacterial growth rates. Ga(NO3)3 activity was strongly dependent on iron availability in the culture medium, though the mechanism of growth inhibition was independent of dysregulation of gene expression controlled by the ferric uptake regulator Fur. Ga(NO3)3 also protected Galleria mellonella larvae from lethal A. baumannii infection, with survival rates of ≥75%. At therapeutic concentrations for humans (28 μM plasma levels), Ga(NO3)3 inhibited the growth in human serum of 76% of the multidrug-resistant A. baumannii isolates tested by ≥90%, raising expectations on the therapeutic potential of gallium for the treatment of A. baumannii bloodstream infections. Ga(NO3)3 also showed strong synergism with colistin, suggesting that a colistin-gallium combination holds promise as a last-resort therapy for infections caused by pan-resistant A. baumannii. 相似文献
56.
57.
58.
59.
This study described the prevalence of adults with shortened dental arches (SDA) in Brazil, specifically assessing the differences of oral health‐related quality of life [the prevalence and severity of oral impacts on daily performance (OIDP)] by dentition status. We analysed data from the 2010 National Survey of Oral Health in Brazil, including home interviews and oral examinations. The assessment of SDA used two alternative definitions: having 3–5 natural occlusal units (OUs) in posterior teeth or having 4 OUs in posterior teeth. Both definitions included having intact anterior region and no dental prosthesis. The analysis was weighted, and a complex sampling design was used. Negative binomial regression models assessed associations as adjusted for socio‐demographic conditions and dental outcomes. A total of 9779 adults (35–44 years old) participated in the study. A non‐negligible proportion had SDA: 9·9% and 3·8% for the first and second definition, respectively. Individuals with SDA (first definition) ranked higher in OIDP prevalence [count ratio (CR) 1·22; 1·09–1·36, 95% confidence interval (CI)] and severity (CR = 1·43; 1·19–1·72, 95% CI) than those with more natural teeth. This difference was not statistically significant when adjusted for socio‐demographic and dental covariates: OIDP prevalence (CR = 1·04; 0·92–1·17, 95% CI) and severity (CR = 1·09; 0·91–1·30, 95% CI). Analogous results were obtained when the second definition of SDA was adopted. These findings suggest that a considerable contingent of adults may function well without dental prostheses, despite having several missing teeth. This conclusion challenges the traditional approach of replacing any missing tooth and instructs the allocation of more dental resources to preventive, diagnostic and restorative services. 相似文献
60.
The evaluation of gastrointestinal function in diabetic patients 总被引:2,自引:0,他引:2
Quigley EM 《World journal of gastroenterology : WJG》1999,5(4):13-282
Nowadays,anumberofoptionsareavailablefortheasesmentofgastricmotorfunction.Thus,aglobalevaluationofgastricmotorfunctionmaybeob... 相似文献