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51.
Cristiano Bombardi Annamaria Grandis Anna Gardini Bruno Cozzi 《Anatomical record (Hoboken, N.J. : 2007)》2013,296(10):1603-1614
Nitric oxide (NO) is a freely diffusible gaseous neurotransmitter generated by a selected population of neurons and acts as a paracrine molecule in the nervous system. NO is synthesized from l ‐arginine by means of the neuronal nitric oxide synthase (nNOS), an enzyme requiring nicotine adenine dinucleotide phosphate (NADPH) as cofactor. In this study, we used histochemical and immunohistochemical techniques to investigate the distribution of NADPH‐diaphorase (NADPH‐d) and nNOS in the spinal cord of the bottlenose dolphin (Tursiops truncatus). Cells with a fusiform‐shaped somata were numerous in the laminae I and II. The intermediolateral horn showed darkly‐stained cells with a multipolar morphology. Neurons with a multipolar or fusiform morphology were observed in the ventral horn. Multipolar and fusiform neurons were the most common cell types in lamina X. Nitrergic fibers were numerous especially in the dorsal and intermediolateral horns. The presence of nitrergic cells and fibers in different laminae of the spinal cord suggests that NO may be involved in spinal sensory and visceral circuitries, and potentially contribute to the regulation of the complex retia mirabilia. Anat Rec, 296:1603–1614, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
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54.
Colao A 《Pituitary》2012,15(1):50-58
In acromegaly, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) excess results in a specific cardiomyopathy characterized
by concentric cardiac hypertrophy primarily associated with diastolic dysfunction that can lead to impaired systolic function
and eventually heart failure. This review of the literature evaluates the effect of therapeutic intervention on cardiac parameters.
Clinical studies investigating the impact of treatments for acromegaly on cardiac function published between January 1980
and January 2009 were identified through electronic searches of Medline. Suppression of GH and IGF-1 following surgery or
medical treatment with somatostatin analogue therapy is effective in decreasing left ventricular (LV) hypertrophy, with subsequent
improvement in cardiac function. First-line treatment with somatostatin analogues resulted in improved cardiac outcome compared
with first-line surgery, possibly due to somatostatin analogues acting directly through somatostatin receptors on cardiac
cells. Additional cardiac improvement has been reported when somatostatin analogue treatment was combined with surgery. In
patients where complete biochemical control was not achieved, an improved cardiac performance following treatment with somatostatin
analogues has been reported. Treatment with pegvisomant has been demonstrated to reduce LV hypertrophy and improve diastolic
and systolic performance. In contrast, reports have suggested that treatment with the dopamine agonist cabergoline increased
the incidence of valvular heart disease. Although surgery and somatostatin analogues are effective in improving cardiomyopathy,
a greater beneficial effect is observed with somatostatin analogue treatment. Selected patients with acromegaly should consider
first-line therapy or pre-treatment with somatostatin analogues prior to surgery to achieve biochemical control and improve
cardiac dysfunction. 相似文献
55.
Porta F Radunovic G Vlad V Micu MC Nestorova R Petranova T Iagnocco A 《Rheumatology (Oxford, England)》2012,51(6):976-982
The use of Doppler techniques, including power, colour and spectral Doppler, has greatly increased in rheumatology in recent years. This is due to the ability of Doppler US (DUS) to detect pathological vascularization within joints and periarticular soft tissues, thereby demonstrating the presence of active inflammation, which has been reported to be correlated with the local neo-angiogenesis. In synovitis, DUS showed a high correlation with histological and MRI findings, thus it is considered a valid tool to detect pathological synovial vascularization. Moreover, it is more sensitive than clinical examination in detecting active joint inflammation and in the evaluation of response to treatment. In addition, DUS may be considered as a reference imaging modality in the assessment of enthesitis, MRI being not sensitive and histology not feasible. Moreover, it has been demonstrated to be able to detect changes in asymptomatic enthesis. In conclusion, DUS is a useful and sensitive tool in the evaluation and monitoring of active inflammation. Its widespread use in clinical rheumatological practice is recommended. The aim of this article is to review the current literature about the role of DUS in rheumatic diseases, analysing its validity, reliability and feasibility. 相似文献
56.
Bruyn GA Möller I Garrido J Bong D d'Agostino MA Iagnocco A Karim Z Terslev L Swen N Balint P Baudoin P van Reesema DS Pineda C Wakefield RJ Naredo E 《Rheumatology (Oxford, England)》2012,51(9):1655-1661
Objective. To assess the intra- and interobserver reliability of musculoskeletal ultrasonography (US) in detecting inflammatory and destructive tendon abnormalities in patients with RA using two different scanning methods. Methods. Thirteen observers examined nine patients with RA and one healthy individual in two rounds independently and blindly of each other. Each round consisted of two consecutive examinations, an anatomy-based examination and a free examination according to personal preferences. The following tendons were evaluated: wrist extensor compartments 2, 4 and 6, finger flexor tendons 3 and 4 at MCP level, tibialis posterior tendon and both peronei tendons. Overall, positive and negative agreements and κ-values for greyscale (GS) tenosynovitis, peritendinous power Doppler (PPD) signal, intratendinous power Doppler (IPD) signal and GS tendon damage were calculated. Results. Intraobserver κ-value ranges were 0.53-0.55 (P?0.0005) for GS tenosynovitis, 0.61-0.64 (P?0.0005) for PPD signal, 0.65-0.66 (P?0.0005) for IPD signal and 0.44-0.53 (P?0.0005) for GS tendon damage. For interobserver reliability, substantial overall agreement ranged from 80 to 89% for GS tenosynovitis, 97 to 100% for PPD signal, 97 to 100% for IPD signal and 97 to 100% for GS tendon damage. Results were independent of scanning technique. Conclusion. Intraobserver reliability for tenosynovitis and tendon damage varied from moderate for GS to good for PD. Overall interobserver reliability for tenosynovitis and tendon damage was excellent both for GS and PD. This qualitative scoring system may serve as the first step to a semi-quantitative score for tendon pathology. 相似文献
57.
Mandl P Naredo E Conaghan PG D'Agostino MA Wakefield RJ Bachta A Backhaus M Hammer HB Bruyn GA Damjanov N Filippucci E Grassi W Iagnocco A Jousse-Joulin S Kane D Koski JM Möller I De Miguel E Schmidt WA Swen WA Szkudlarek M Terslev L Ziswiler HR Ostergaard M Balint PV 《Rheumatology (Oxford, England)》2012,51(1):184-190
58.
Oriana Simonetti Guendalina Lucarini Oscar Cirioni Antonio Zizzi Fiorenza Orlando Mauro Provinciali Roberto Di Primio Andrea Giacometti Annamaria Offidani 《Burns : journal of the International Society for Burn Injuries》2013
Age-related differences in wound healing have been documented but little is known about the wound healing mechanism after burns. Our aim was to compare histological features and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9), collagen IV, K6 and CD44 in the burn wound healing process in aged and young rats. 相似文献
59.
Giannoccaro Maria Pia Vacchiano Veria Leone Marta Camilli Federico Zenesini Corrado Panzera Ivan Balboni Alice Tappatà Maria Borghi Annamaria Salvi Fabrizio Lugaresi Alessandra Rinaldi Rita Di Felice Giulia Lodi Vittorio Lazzarotto Tiziana Liguori Rocco 《Journal of neurology》2022,269(8):4000-4012
Journal of Neurology - Assessing the safety of SARS-CoV-2 mRNA vaccines and the effect of immunotherapies on the seroconversion rate in patients with autoimmune neurological conditions (ANC) is... 相似文献
60.
Annamaria Mascolo Pasquale Maria Berrino Pietro Gareri Alberto Castagna Annalisa Capuano Ciro Manzo Liberato Berrino 《Inflammopharmacology》2018,26(5):1141-1149
Little is known about the development of psychosis during hydroxychloroquine (HCQ) treatment, especially in elderly patients affected by rheumatic diseases, with multiple comorbidities and treatments. To summarize the available evidence on HCQ-induced psychosis in elders, we performed a literature review. Additionally, individual case safety reports sent to the European Pharmacovigilance database (EudraVigilance) with HCQ as suspected drug and related to adverse events belonging to the System Organ Class ‘Psychiatric disorders’ were shown. Over the years, evidence was published about the risk of neuropsychiatric clinical manifestations during HCQ treatment for rheumatic diseases, but few of them were related to elderly patients. These adverse events can include less severe clinical manifestations such as affect lability and nervousness or more severe conditions such as actual psychosis and suicidal tendencies, which frequency are actually unknown. The presence of risk factors in these patients may precipitate HCQ-induced psychosis and their precocious detection could be associated with a risk minimization. Among predisposing risk factors, there are the co-exposure to interacting drugs, alcohol intake, familial history of psychiatric diseases, female gender, and the concomitant use of low-dose glucocorticoids. In some cases it was possible to reverse psychotic behaviour with the antipsychotic treatment or with HCQ suspension. 相似文献