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An international consensus report on a new algorithm for the management of infant diarrhoea 下载免费PDF全文
Marc Benninga Ilse Broekaert Jackie Falconer Frederic Gottrand Carlos Lifschitz Paolo Lionetti Rok Orel Alexandra Papadopoulou Carmen Ribes‐Koninckx Silvia Salvatore Raanan Shamir Michela Schäppi Annamaria Staiano Hania Szajewska Nikhil Thapar Michael Wilschanski Alfredo Guarino 《Acta paediatrica (Oslo, Norway : 1992)》2016,105(8):e384-e389
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Luigi Strizzi Annamaria Sandomenico Naira V. Margaryan Annalia Focà Luca Sanguigno Thomas M. Bodenstine Grace S. Chandler David W. Reed Alina Gilgur Elisabeth A. Seftor Richard E.B. Seftor Zhila Khalkhali-Ellis Antonio Leonardi Menotti Ruvo Mary J.C. Hendrix 《Oncotarget》2015,6(33):34071-34086
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161 human melanoma cells with 3D1 mAb shows reductions in anchorage-independent growth and vasculogenic network formation. 3D1 treated cells also show decreases of Nodal and downstream signaling molecules, P-Smad2 and P-ERK and of P-H3 and CyclinB1, with an increase in p27. Similar effects were previously reported in human breast cancer cells where Nodal expression was generally down-regulated; following 3D1 mAb treatment, both Nodal and P-H3 levels are reduced. Noteworthy is the reduced growth of human melanoma xenografts in Nude mice treated with 3D1 mAb, where immunostaining of representative tumor sections show diminished P-Smad2 expression. Similar effects both in vitro and in vivo were observed in 3D1 treated A375SM melanoma cells harboring the active BRAF(V600E) mutation compared to treatments with IgG control or a BRAF inhibitor, dabrafenib. Finally, we describe a 3D1-based ELISA for the detection of Nodal in serum samples from cancer patients. These data suggest the potential of 3D1 mAb for selecting and targeting Nodal expressing cancers. 相似文献
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A Dedicated Nutritional Care Program (NUTRICARE) to reduce malnutrition in institutionalised dysphagic older people: A quasi‐experimental study 下载免费PDF全文
Milko Zanini PhD MSN MSoc Annamaria Bagnasco PhD Gianluca Catania PhD MSN RN Giuseppe Aleo PhD MA Marina Sartini BSC PhD Maria Luisa Cristina MSc MNatSc Stefania Ripamonti MSBiol Fiammetta Monacelli PhD MD Patrizio Odetti MD Loredana Sasso MSN FAAN 《Journal of clinical nursing》2017,26(23-24):4446-4455
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Annamaria Nagy Aniko Rentka Gabor Nemeth Hassan Ziad Gabriella Szücs Zoltán Szekanecz 《Ocular immunology and inflammation》2013,21(6):968-977
Purpose: Corneal involvement in systemic sclerosis (SSc) is rare, but due to rich collagen composition cornea is especially vulnerable to connective tissue diseases. Therefore, our aim was to evaluate corneal parameters of SSc patients.Methods: The study included 32 SSc patients and 39 control subjects with no ocular symptoms or ocular surface disorders. All study participants underwent Pentacam evaluation and objective signs of dry eye disease (DED), and clinical parameters were evaluated.Results: All pachymetric values, most of the corneal front surface, corneal volume, as well as anterior chamber depth measurements were significantly lower in the SSc group than in the control group (p < 0.05). Significant negative correlation was found between corneal parameters and age on the one hand, and disease duration on the other.Conclusions: Early recognition of corneal impairment, a possible extraintestinal manifestation of SSc, should be included in the check-up of the disease in order to reduce sight-threatening complications. 相似文献
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