全文获取类型
收费全文 | 2641篇 |
免费 | 149篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 58篇 |
妇产科学 | 67篇 |
基础医学 | 265篇 |
口腔科学 | 38篇 |
临床医学 | 190篇 |
内科学 | 645篇 |
皮肤病学 | 20篇 |
神经病学 | 235篇 |
特种医学 | 105篇 |
外科学 | 560篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 82篇 |
眼科学 | 18篇 |
药学 | 209篇 |
中国医学 | 2篇 |
肿瘤学 | 292篇 |
出版年
2023年 | 17篇 |
2022年 | 34篇 |
2021年 | 42篇 |
2020年 | 40篇 |
2019年 | 52篇 |
2018年 | 62篇 |
2017年 | 50篇 |
2016年 | 47篇 |
2015年 | 50篇 |
2014年 | 92篇 |
2013年 | 118篇 |
2012年 | 161篇 |
2011年 | 120篇 |
2010年 | 84篇 |
2009年 | 69篇 |
2008年 | 104篇 |
2007年 | 106篇 |
2006年 | 114篇 |
2005年 | 116篇 |
2004年 | 95篇 |
2003年 | 98篇 |
2002年 | 92篇 |
2001年 | 83篇 |
2000年 | 92篇 |
1999年 | 72篇 |
1998年 | 32篇 |
1997年 | 32篇 |
1996年 | 29篇 |
1995年 | 26篇 |
1994年 | 26篇 |
1993年 | 15篇 |
1992年 | 65篇 |
1991年 | 56篇 |
1990年 | 43篇 |
1989年 | 52篇 |
1988年 | 52篇 |
1987年 | 45篇 |
1986年 | 31篇 |
1985年 | 36篇 |
1984年 | 23篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1980年 | 13篇 |
1978年 | 14篇 |
1977年 | 14篇 |
1974年 | 12篇 |
1973年 | 14篇 |
1972年 | 14篇 |
1971年 | 23篇 |
1967年 | 13篇 |
排序方式: 共有2804条查询结果,搜索用时 0 毫秒
41.
Edoardo Conte Daniele Andreini Marco Magnoni Serge Masson Saima Mushtaq Sergio Berti Mauro Canestrari Giancarlo Casolo Domenico Gabrielli Roberto Latini Paolo Marraccini Tiziano Moccetti Maria Grazia Modena Gianluca Pontone Marco Gorini Aldo P. Maggioni Attilio Maseri 《Journal of Cardiovascular Computed Tomography》2021,15(1):73-80
BackgroundHigh-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA.MethodsA consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features.Results528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively).ConclusionsOur results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis. 相似文献
42.
Minkwan Kim Seung-Pyo Lee Soongu Kwak Seokhun Yang Yong-Jin Kim Daniele Andreini Mouaz H. Al-Mallah Matthew J. Budoff Filippo Cademartiri Kavitha Chinnaiyan Jung Hyun Choi Edoardo Conte Hugo Marques Pedro de Araújo Gonçalves Ilan Gottlieb Martin Hadamitzky Jonathon A. Leipsic Erica Maffei Hyuk-Jae Chang 《Journal of Cardiovascular Computed Tomography》2021,15(3):232-239
BackgroundThe association of age with coronary plaque dynamics is not well characterized by coronary computed tomography angiography (CCTA).MethodsFrom a multinational registry of patients who underwent serial CCTA, 1153 subjects (61 ± 5 years old, 61.1% male) were analyzed. Annualized volume changes of total, fibrous, fibrofatty, necrotic core, and dense calcification plaque components of the whole heart were compared by age quartile groups. Clinical events, a composite of all-cause death, acute coronary syndrome, and any revascularization after 30 days of the initial CCTA, were also analyzed. Random forest analysis was used to define the relative importance of age on plaque progression.ResultsWith a 3.3-years’ median interval between the two CCTA, the median annual volume changes of total plaque in each age quartile group was 7.8, 10.5, 10.8, and 12.1 mm3/year and for dense calcification, 2.5, 4.6, 5.4, and 7.1 mm3/year, both of which demonstrated a tendency to increase by age (p-for-trend = 0.001 and < 0.001, respectively). However, this tendency was not observed in any other plaque components. The annual volume changes of total plaque and dense calcification were also significantly different in the propensity score-matched lowest age quartile group versus the other age groups as was the composite clinical event (log-rank p = 0.003). In random forest analysis, age had comparable importance in the total plaque volume progression as other traditional factors.ConclusionsThe rate of whole-heart plaque progression and dense calcification increases depending on age. Age is a significant factor in plaque growth, the importance of which is comparable to other traditional risk factors.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifiers: NCT02803411. 相似文献
43.
Allergen Component Specific IgE Measurement With the Immulite™ 2000 System: Diagnostic Accuracy and Intermethod Comparison 下载免费PDF全文
44.
Enrico Cecchi Massimo Imazio Franco Pomari Ivano Dal Conte Costantina Preziosi Filippo Lipani Rita Trinchero 《Italian heart journal》2005,6(12):972-976
BACKGROUND: HIV infection is one of the leading causes of acquired heart disease. Because of its high diffusion, systematic echocardiographic monitoring has been proposed to exclude cardiovascular involvement in these patients. The aim of this study was to evaluate an alternative clinical approach by which echocardiographic screening is limited to patients with a clinical suspicion of heart disease. METHODS: We studied 2030 consecutive HIV-infected patients admitted to a tertiary referral hospital (group A). History, physical examination, ECG, and chest X-ray were used to screen HIV-infected patients for cardiovascular involvement. Selected patients were extensively studied, first of all by echocardiography. Cardiovascular and non-cardiovascular deaths were recorded: RESULTS: Cardiovascular involvement was clinically suspected in 201 patients (9.9%; group B). Among them a higher extracardiac mortality was found in presence of pericardial disease (odds ratio [OR] 4.27, 95% confidence interval [CI] 2.01-9.09), while a higher cardiovascular mortality was recorded for patients with cardiomyopathy or myocarditis (OR 2.72, 95% CI 1.09-6.81), and right ventricular dysfunction and/or pulmonary hypertension (OR 4.67, 95% CI 1.44-15.2). Compared with group A, patients in group B had a significantly increased cardiac death rate (0.114 vs 0.018, p < 0.001). A positive echocardiogram slightly increased this rate (from 0.114 to 0.164, p = NS), whereas a negative echocardiogram significantly decreased the cardiac death rate (0.015 vs 0.164, p = 0.004). CONCLUSIONS: Clinical selection of HIV-infected patients with suspected cardiovascular involvement may help identify patients with higher frequency of cardiovascular involvement. Among these patients, echocardiography may be a useful screening tool in those at high risk for cardiovascular death. 相似文献
45.
Gian-Battista Chierchia Giacomo Di Giovanni Juan Sieira-Moret Carlo de Asmundis Giulio Conte Moises Rodriguez-Mañero Ruben Casado-Arroyo Giannis Baltogiannis Gaetano Paparella Giuseppe Ciconte Andrea Sarkozy Pedro Brugada 《Journal of interventional cardiac electrophysiology》2014,39(2):145-151
Background
The second-generation cryoballoon (CB-A) (Arctic Front Advance, Cryocath, Medtronic, MN, USA) might significantly improve procedural outcome with respect to the first-generation balloon. These technological improvements might also question the current recommendation of the need a 4-min freeze to achieve durable pulmonary vein isolation (PVI).Objective
The main aim of the study was to analyze the procedural efficacy of a 3-min freeze–thaw cycles with the CB-A balloon in the terms of rates of acute PVI and 6-month outcome.Methods
Patients having undergone CB-A for PAF or early persistent AF, with 3-min freeze–thaw cycles were consecutively included in our analysis. Acute procedural success was measured in terms of the rate of PVI. Short-term follow-up was evaluated by the means of 24-h Holters and clinical examinations at regular intervals.Results
Fifty-two consecutive patients (35 male (67 %); mean age, 59.8?±?10.5) were included. Mean procedure and fluoroscopy times were 96?±?15 and 13.2?±?8.3 min, respectively. Mean time from groin puncture to catheter extraction was 60.4?±?20 min. After a mean of 1.5 freeze cycles per vein of 3 min in duration, all 208 (100 %) PVs could be isolated with the CB-A. A total 192 (91 %) veins were isolated during the first freeze. At a mean of 5.7-month follow-up, 82 % of patients were free of AF.Conclusion
CB-A is effective in producing PVI by using 3-min-duration freeze cycles. After a mean of 1.5 freeze per vein, freedom from AF was achieved in 82 % of patients at 6-month follow-up. 相似文献46.
Virginia R. Mckay M. Margaret Dolcini Kathleen P. Conte Joseph A. Catania 《Journal of community psychology》2014,42(8):891-906
Understanding the balance between fidelity and adaptation for evidence‐based interventions has the potential to improve their translation from research to practice. The Translation into Practice study explores variation in program implementation within organizations utilizing the RESPECT program, an HIV counseling and testing intervention. Counselors (N = 70) were interviewed using a semistructured interview guide to examine both the influential factors on, and the subsequent adaptations to, RESPECT. Almost all counselors reported making adaptations (N = 69). Adaptations were made both to key characteristics (mean [M] = 2.24, standard deviation [SD] = 1.3) and to core components (M = 0.5, SD = 0.8). Counselors identified the environmental context and factors within the counseling context as common influences leading to adaptation. These findings suggest adaptations were a routine part of program usage. To improve implementation of the RESPECT program, further research is needed to assess the degree to which adaptations can be made to better meet the needs of agencies and clients without compromising fidelity. 相似文献
47.
Paolo Spirito Camillo Autore Francesco Formisano Gabriele Egidy Assenza Elena Biagini Tammy S. Haas Sergio Bongioanni Christopher Semsarian Emmanuela Devoto Beatrice Musumeci Francesco Lai Laura Yeates Maria Rosa Conte Claudio Rapezzi Luca Boni Barry J. Maron 《The American journal of cardiology》2014
48.
49.
Mariano Serrao Carmela Conte Carlo Casali Alberto Ranavolo Silvia Mari Roberto Di Fabio Armando Perrotta Gianluca Coppola Luca Padua Stefano Monamì Giorgio Sandrini Francesco Pierelli 《Cerebellum (London, England)》2013,12(5):607-616
Stopping during walking, a dynamic motor task frequent in everyday life, is very challenging for ataxic patients, as it reduces their gait stability and increases the incidence of falls. This study was conducted to analyse the biomechanical characteristics of upper and lower body segments during abrupt stopping in ataxic patients in order to identify possible strategies used to counteract the instability in the sagittal and frontal plane. Twelve patients with primary degenerative cerebellar ataxia and 12 age- and sex-matched healthy subjects were studied. Time–distance parameters, dynamic stability of the centre of mass, upper body measures and lower joint kinematic and kinetic parameters were analysed. The results indicate that ataxic patients have a great difficulty in stopping abruptly during walking and adopt a multi-step stopping strategy, occasionally with feet parallel, to compensate for their inability to coordinate the upper body and to generate a well-coordinated lower limb joint flexor–extensor pattern and appropriate braking forces for progressively decelerating the progression of the body in the sagittal plane. A specific rehabilitation treatment designed to improve the ability of ataxic patients to transform unplanned stopping into planned stopping, to coordinate upper body and to execute an effective flexion–extension pattern of the hip and knee joints may be useful in these patients in order to improve their stopping performance and prevent falls. 相似文献
50.
U. Maggi G. Conte G. Nita S. Gatti G. Paone L. Caccamo R. Lauro D. Dondossola E. Buscarini G. Rossi 《Transplantation proceedings》2013
Liver transplantation (LT) in patients with hereditary hemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber, disease is a problematic procedure. In patients with hepatic involvement due to clinically significant arterovenous malformations, there is high risk of intraoperative bleeding and intra- or perioperative complications. Some surgical corrections have been proposed for venous problems, concerning the vena caval anastomosis. A common finding in HHT is arterial enlargement of the celiac trunk and of the common hepatic artery. We report 2 cases of LT in HHT where the arterial anastomosis was successfully performed using the splenic artery of the recipient, which shows less tendency for enlargement than the celiac trunk. 相似文献