全文获取类型
收费全文 | 34600篇 |
免费 | 2844篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 286篇 |
儿科学 | 1304篇 |
妇产科学 | 1065篇 |
基础医学 | 4410篇 |
口腔科学 | 582篇 |
临床医学 | 5798篇 |
内科学 | 6299篇 |
皮肤病学 | 509篇 |
神经病学 | 3317篇 |
特种医学 | 697篇 |
外国民族医学 | 1篇 |
外科学 | 3362篇 |
综合类 | 422篇 |
一般理论 | 68篇 |
预防医学 | 4307篇 |
眼科学 | 483篇 |
药学 | 1895篇 |
1篇 | |
中国医学 | 32篇 |
肿瘤学 | 2686篇 |
出版年
2023年 | 167篇 |
2022年 | 238篇 |
2021年 | 573篇 |
2020年 | 480篇 |
2019年 | 798篇 |
2018年 | 843篇 |
2017年 | 628篇 |
2016年 | 780篇 |
2015年 | 819篇 |
2014年 | 1065篇 |
2013年 | 1618篇 |
2012年 | 2273篇 |
2011年 | 2306篇 |
2010年 | 1284篇 |
2009年 | 1181篇 |
2008年 | 2168篇 |
2007年 | 2329篇 |
2006年 | 2305篇 |
2005年 | 2233篇 |
2004年 | 2101篇 |
2003年 | 2039篇 |
2002年 | 1916篇 |
2001年 | 488篇 |
2000年 | 457篇 |
1999年 | 449篇 |
1998年 | 487篇 |
1997年 | 367篇 |
1996年 | 350篇 |
1995年 | 348篇 |
1994年 | 286篇 |
1993年 | 271篇 |
1992年 | 257篇 |
1991年 | 232篇 |
1990年 | 219篇 |
1989年 | 240篇 |
1988年 | 189篇 |
1987年 | 167篇 |
1986年 | 196篇 |
1985年 | 195篇 |
1984年 | 186篇 |
1983年 | 169篇 |
1982年 | 175篇 |
1981年 | 165篇 |
1980年 | 168篇 |
1979年 | 117篇 |
1978年 | 106篇 |
1977年 | 88篇 |
1976年 | 96篇 |
1975年 | 87篇 |
1974年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Toward a VA women’s health research agenda: Setting evidence-based priorities to improve the health and health care of women veterans
下载免费PDF全文
![点击此处可从《Journal of general internal medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Elizabeth M. Yano Lori A. Bastian Susan M. Frayne Alexandra L. Howell Linda R. Lipson Geraldine McGlynn Paula P. Schnurr Margaret R. Seaver Ann M. Spungen Stephan D. Fihn 《Journal of general internal medicine》2006,21(3):S93-S101
The expansion of women in the military is reshaping the veteran population, with women now constituting the fastest growing segment of eligible VA health care users. In recognition of the changing demographics and special health care needs of women, the VA Office of Research & Development recently sponsored the first national VA Women’s Health Research Agenda-setting conference to map research priorities to the needs of women veterans and position VA as a national leader in Women’s Health Research. This paper summarizes the process and outcomes of this effort, outlining VA’s research priorities for biomedical, clinical, rehabilitation, and health services research. 相似文献
82.
Potassium and magnesium were measured in 26 cardiac surgery patients (right atrial appendage), 23 autopsy subjects (right atrial appendage, left ventricular free wall, and skeletal muscle), and 9 healthy volunteers (mononuclear blood cells) to determine whether there was a relation between these two ions in the tissues measured. In the cardiac surgery patients, the potassium and magnesium concentrations were 46.35 +/- 3.89 and 4.40 +/- 0.58 (mean +/- SD, mumol/g wet weight tissue), respectively, and were significantly correlated (r = 0.54, P = 0.005). In the autopsy group, the respective concentrations were: for right atrial appendage, 30.54 +/- 10.18 and 3.66 +/- 0.70 mumol/g (r = 0.38, P = 0.14); left ventricular free wall, 60.69 +/- 17.93 and 7.74 +/- 1.73 mumol/g (r = 0.92, P = 0.0001); and skeletal muscle, 93.05 +/- 20.49 and 8.64 +/- 2.06 mumol/g (r = 0.91, P = 0.0001). In the healthy volunteer group, the results for potassium and magnesium in mononuclear blood cells were 42 +/- 9.9 and 3.99 +/- 0.70 fmol/cell, respectively (r = 0.94, P = 0.0001). Thus, potassium and magnesium concentrations were significantly correlated in all the tissues measured. 相似文献
83.
84.
Shreyasee Amin B Lawrence Riggs Elizabeth J Atkinson Ann L Oberg L Joseph Melton Sundeep Khosla 《Journal of bone and mineral research》2004,19(7):1075-1083
The role of the IGFs and IGFBPs on age-related changes in BMD in adult men and women is not well understood. Studying an age-stratified community based sample of 344 men and 276 women, we found higher IGFBP-2 levels to be associated with lower BMD. IGFBP-2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied. INTRODUCTION: Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important regulators of tissue growth and metabolism, but their association with BMD in adult men and women is controversial. MATERIALS AND METHODS: In an age-stratified, random sample of the community population, we examined the role of serum levels of IGF-I, IGF-II, and IGFBP-1, -2, and -3 on BMD of the proximal femur (total hip), lateral spine, midshaft, and ultradistal radius as measured by DXA. We explored the association before and after adjustment for potential confounders, including age, bioavailable estradiol and testosterone, sex hormone binding globulin (SHBG), and measures of total fat and skeletal muscle mass. RESULTS: We studied 344 men (age, 23-90 years) and 276 women (age, 21-93 years; 166 postmenopausal) not on hormone replacement or oral contraceptives. In both men and women, IGF-I and IGFBP-3 levels fell with advancing age, whereas IGFBP-2 levels tended to rise with age. There was an inverse association of IGFBP-2 with BMD at most skeletal sites in men and both premenopausal and postmenopausal women, whereas lower IGF-I and IGFBP-3 were associated with lower BMD in men and postmenopausal women only. Lower IGF-II was associated with lower BMD in men only. There were no associations between IGFBP-1 and BMD in either sex. After adjustment for age, in most cases, we found no further associations between IGF-I, IGF-II, or IGFBP-3 and BMD. In contrast, after age adjustment, higher IGFBP-2 remained a predictor of lower BMD in men and postmenopausal women at all sites except for the lateral spine (for men: r = -0.21, -0.20, and -0.19, all p < 0.001; and for postmenopausal women: r = -0.34, -0.24, and -0.25, all p < 0.01, for the total hip, midshaft, and ultradistal radius, respectively). IGFBP-2 remained an independent negative predictor of BMD in men, postmenopausal women, and all women combined after additional adjustment for bioavailable sex steroids, but not at all sites after adjustment for SHBG and muscle mass. In premenopausal women, IGFBP-2 had similar associations as seen in postmenopausal women, but they were weaker and not statistically robust. CONCLUSIONS: Among the IGF/IGFBPs in our study, IGFBP-2 was a key negative predictor of BMD among men and women, particularly postmenopausal women. Our findings suggest a potential role of the IGF/IGFBP system in regulating bone loss in aging men and women and identify a previously under-recognized, potentially deleterious role for IGFBP-2, a known inhibitor of IGF action that increases with age in both sexes. Whether the action of the IGF/IGFBP system on bone metabolism is mediated partly through its effects on muscle mass or SHBG deserves further study. 相似文献
85.
Christopher James Caunt Ann R Finch Kathleen R Sedgley Craig A McArdle 《Trends in Endocrinology and Metabolism》2006,17(8):308-313
Many hormones, neurotransmitters and growth factors influence their target cells by activation of mitogen-activated protein kinase cascades. The consequences of such activation reflect not only the magnitude, but also the kinetics and cellular compartmentalization of kinase activity. Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, a structure present in all other seven-transmembrane receptors. Here, we review spatiotemporal aspects of extracellular-signal-regulated kinase activation by gonadotropin-releasing hormone receptors, emphasizing how the absence or presence of the carboxyl-terminal tail dictates the receptors' ability to engage and signal via arrestins. 相似文献
86.
Summary
Malignant lymphomas can be subdivided into Hodgkin's disease and low- or high-grade non-Hodgkin's lymphoma (NHL). The principal
therapeutic options are polychemotherapy and radiotherapy. Besides the histological classification, staging of the disease
with particular regard to risk factors is an essential prerequisite for the therapeutic decision. Diagnostic imaging modalities
such as computer tomography, magnetic resonance imaging, and ultrasonography have improved the accuracy of clinical staging
such that invasive pathological staging is only necessary in exceptional cases. A novel therapeutic approach is high-dose
chemotherapy with autologous haematopoietic stem-cell support. This treatment improves the survival of patients with relapsed
high-grade NHL. The place of high-dose therapy as the primary therapeutic option in malignant lymphoma is now being assessed
in prospective studies following encouraging results from single-centre studies, including those involving the treatment of
low-grade lymphoma. The effects of antibodies directed against lymphatic cells are currently being examined in experimental
treatments. An assessment of the viability and rate of proliferation of lymphoma tissue on completion of therapy using sensitive
radiological and nuclear medical methods is an important aim for the future.
Eingegangen am 5. November 1996 Angenommen am 12. November 1996 相似文献
87.
88.
Prediction of Remission of Acute Posttraumatic Stress Disorder in Motor Vehicle Accident Victims 总被引:1,自引:0,他引:1
Edward B. Blanchard Edward J. Hickling Catherine A. Forneris Ann E. Taylor Todd C. Buckley Warren R. Loos James Jaccard 《Journal of traumatic stress》1997,10(2):215-234
One hundred forty five individuals who sought medical attention as a result of a motor vehicle accident (MVA), and who were initially assessed 1 to 4 months post-MVA, were followed up prospectively for 6 months to determine how many of the 55 with posttraumatic stress disorder (PTSD) and the 43 with sub-syndromal PTSD would remit and what variables would predict remission. Thirty (55%) of those with initial PTSD had remitted at least in part by 6 months while 67% of those with sub-syndromal PTSD had remitted (and 5% had worsened). Four variables, including severity of initial symptoms, degree of initial physical injury, relative degree of physical recovery by 4 months and whether a close family member suffered a trauma during the follow-up interval, combined to classify 6-month clinical status of 84% of those with initial PTSD secondary to MVAs. 相似文献
89.