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991.
Virk Zain M. Song Andrew B. Badran Yousef R. Al-Samkari Hanny 《Journal of thrombosis and thrombolysis》2022,54(2):255-259
Journal of Thrombosis and Thrombolysis - Heyde syndrome is characterized by the co-occurrence of aortic stenosis and bleeding gastrointestinal angiodysplasias, often with acquired von Willebrand... 相似文献
992.
Kawakubo Kazumichi Castillo Carlos Fernandez-del Liss Andrew Scott 《Journal of gastroenterology》2022,57(11):819-826
Journal of Gastroenterology - Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and immune checkpoint inhibitors. Recent studies suggest that epigenetic alterations... 相似文献
993.
Sumpton Daniel Hannan Elyssa Kelly Ayano Tunnicliffe David Ming Andrew Hassett Geraldine Craig Jonathan C Tong Allison 《Clinical rheumatology》2021,40(4):1369-1380
Clinical Rheumatology - Shared care between rheumatologists and dermatologists is advocated for patients with psoriasis and psoriatic arthritis, but care provided by rheumatologists and... 相似文献
994.
Philip Moons Koen Luyckx Corina Thomet Werner Budts Junko Enomoto Maayke A. Sluman Chun-Wei Lu Jamie L. Jackson Paul Khairy Stephen C. Cook Shanthi Chidambarathanu Luis Alday Katrine Eriksen Mikael Dellborg Malin Berghammer Bengt Johansson Andrew S. Mackie Samuel Menahem Adrienne H. Kovacs 《The Canadian journal of cardiology》2021,37(2):215-223
BackgroundWe compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects.MethodsIn the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect.ResultsPatients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%).ConclusionsSome types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes. 相似文献
995.
Gallogly Susan Fujisawa Takeshi Hung John D. Brittan Mairi Skinner Elizabeth M. Mitchell Andrew J. Medine Claire Luque Neus Zodda Erika Cascante Marta Hadoke Patrick W. Mills Nicholas L. Tura-Ceide Olga 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(6):1281-1290
Cardiovascular Drugs and Therapy - Endothelial dysfunction is central to the pathogenesis of acute coronary syndrome. The study of diseased endothelium is very challenging due to inherent... 相似文献
996.
Singh Ayesha Coulter Amanda R. Trainor Patrick J. Singam Narayana Sarma V. Aladili Bahjat N. Amraotkar Alok R. Owolabi Ugochukwu S. DeFilippis Andrew P. 《Journal of thrombosis and thrombolysis》2021,51(1):120-128
Journal of Thrombosis and Thrombolysis - Platelet activation and subsequent aggregation is a vital component of atherothrombosis resulting in acute myocardial infarction. Therefore, quantifying... 相似文献
997.
998.
Frankart Andrew J. Nagarajan Rajaram Pater Luke 《Journal of thrombosis and thrombolysis》2021,51(4):877-883
Journal of Thrombosis and Thrombolysis - Cardiac disease following radiation therapy represents a major consideration in the treatment of a variety of malignancies. Damage to the heart can manifest... 相似文献
999.
Pavoni Vittorio Gianesello Lara Horton Andrew 《Journal of thrombosis and thrombolysis》2021,52(2):542-552
Coronavirus 2019 disease (COVID-19) is associated with coagulation dysfunction that predisposes patients to an increased risk for both arterial (ATE) and venous thromboembolism (VTE) and consequent poor prognosis; in particular, the incidence of ATE and VTE in critically ill COVID-19 patients can reach 5% and 31%, respectively. The mechanism of thrombosis in COVID-19 patients is complex and still not completely clear. Recent literature suggests a link between the presence of antiphospholipid antibodies (aPLs) and thromboembolism in COVID-19 patients. However, it remains uncertain whether aPLs are an epiphenomenon or are involved in the pathogenesis of the disease.
相似文献1000.
Thomas Mason William Whittaker Andrew Jones Matt Sutton 《Addiction (Abingdon, England)》2021,116(11):3082-3093