全文获取类型
收费全文 | 3784篇 |
免费 | 274篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 61篇 |
儿科学 | 105篇 |
妇产科学 | 66篇 |
基础医学 | 541篇 |
口腔科学 | 44篇 |
临床医学 | 368篇 |
内科学 | 752篇 |
皮肤病学 | 58篇 |
神经病学 | 362篇 |
特种医学 | 111篇 |
外科学 | 375篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 473篇 |
眼科学 | 132篇 |
药学 | 262篇 |
中国医学 | 4篇 |
肿瘤学 | 325篇 |
出版年
2023年 | 48篇 |
2022年 | 49篇 |
2021年 | 152篇 |
2020年 | 70篇 |
2019年 | 113篇 |
2018年 | 113篇 |
2017年 | 108篇 |
2016年 | 88篇 |
2015年 | 136篇 |
2014年 | 121篇 |
2013年 | 198篇 |
2012年 | 316篇 |
2011年 | 269篇 |
2010年 | 153篇 |
2009年 | 116篇 |
2008年 | 221篇 |
2007年 | 219篇 |
2006年 | 202篇 |
2005年 | 170篇 |
2004年 | 169篇 |
2003年 | 167篇 |
2002年 | 136篇 |
2001年 | 65篇 |
2000年 | 69篇 |
1999年 | 66篇 |
1998年 | 32篇 |
1997年 | 27篇 |
1996年 | 30篇 |
1995年 | 17篇 |
1994年 | 23篇 |
1993年 | 16篇 |
1992年 | 24篇 |
1991年 | 42篇 |
1990年 | 30篇 |
1989年 | 27篇 |
1988年 | 29篇 |
1987年 | 18篇 |
1986年 | 25篇 |
1985年 | 27篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 9篇 |
1979年 | 11篇 |
1978年 | 14篇 |
1977年 | 8篇 |
1975年 | 11篇 |
1971年 | 8篇 |
1967年 | 7篇 |
1966年 | 7篇 |
1965年 | 8篇 |
排序方式: 共有4063条查询结果,搜索用时 15 毫秒
101.
Amelia Christabel Ravi Sharma R. Manikandhan P. Anantanarayanan N. Elavazhagan Pramod Subash 《Journal of maxillofacial and oral surgery》2015,14(2):154-161
Purpose
The aim of this paper is to review the pathophysiology of thermoregulation mechanism, various causes of fever after maxillofacial surgery and the different treatment protocols advised in the literature.Discussion
Fever is one of the most common complaints after major surgery and is also considered to be an important clinical sign which indicates developing pathology that may go unnoticed by the clinician during post operative period. Several factors are responsible for fever after the maxillofacial surgery, inflammation and infection being the commonest. However, other rare causes such as drug allergy, dehydration, malignancy and endocrinological disorders, etc. should be ruled out prior to any definite diagnosis and initiate the treatment. Proper history and clinical examination is an essential tool to predict the causative factors for fever. Common cooling methods like tepid sponging are usually effective alone or in conjunction with analgesics to reduce the temperature.Conclusion
Fever is a common postoperative complaint and should not be underestimated as it may indicate a more serious underlying pathology. A specific guideline towards the management of such patients is necessary in every hospital setting to ensure optimal care towards the patients during post operative period. 相似文献102.
103.
104.
A novel T‐cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice 下载免费PDF全文
Sojung Kim Amelia K. Pinto Nancy B. Myers Oriana Hawkins Krysten Doll Saghar Kaabinejadian Jason Netland Michael J. Bevan Jon A. Weidanz William H. Hildebrand Michael S. Diamond Ted H. Hansen 《European journal of immunology》2014,44(7):1936-1946
We used a newly generated T‐cell receptor mimic monoclonal antibody (TCRm MAb) that recognizes a known nonself immunodominant peptide epitope from West Nile virus (WNV) NS4B protein to investigate epitope presentation after virus infection in C57BL/6 mice. Previous studies suggested that peptides of different length, either SSVWNATTAI (10‐mer) or SSVWNATTA (9‐mer) in complex with class I MHC antigen H‐2Db, were immunodominant after WNV infection. Our data establish that both peptides are presented on the cell surface after WNV infection and that CD8+ T cells can detect 10‐ and 9‐mer length variants similarly. This result varies from the idea that a given T‐cell receptor (TCR) prefers a single peptide length bound to its cognate class I MHC. In separate WNV infection studies with the TCRm MAb, we show that in vivo the 10‐mer was presented on the surface of uninfected and infected CD8α+CD11c+ dendritic cells, which suggests the use of direct and cross‐presentation pathways. In contrast, CD11b+CD11c? cells bound the TCRm MAb only when they were infected. Our study demonstrates that TCR recognition of peptides is not limited to certain peptide lengths and that TCRm MAbs can be used to dissect the cell‐type specific mechanisms of antigen presentation in vivo. 相似文献
105.
Sarah R. Auclair Kenneth E. Roth Bryan L. Saunders Kathryn M. Ogborn Abdalla A. Sheikh Julianne Naples Anna Marie P. Young Dorottya K. Boisen Amelia T. Tavangar Jane E. Welch Chris S. Lantz 《Infection and immunity》2014,82(3):1308-1314
The contribution of interleukin-3 (IL-3), a hematopoietic growth factor and immunoregulatory cytokine, to resistance to blood-stage malaria was investigated by infecting IL-3-deficient (knockout [KO]) mice with Plasmodium berghei NK65. Male IL-3 KO mice, but not female mice, were more resistant to infection than wild-type (WT) mice, as evidenced by lower peak parasitemia and prolonged survival. Both male and female IL-3 KO mice had increased splenomegaly and were more anemic than corresponding WT mice. Anemia was compensated for by an increase in bone marrow and splenic erythropoiesis in IL-3 KO mice, as evidenced by higher levels of erythroid progenitors. Plasma levels of gamma interferon (IFN-γ) and CXCL9 (monokine induced by IFN-γ [MIG]) were found to be significantly reduced in IL-3 KO mice during early stages of infection. In contrast, granulocyte colony-stimulating factor (G-CSF) levels were significantly higher, and the percentage of peripheral blood neutrophils lower, in infected IL-3 KO mice than in WT counterparts. Overall, our results indicate that IL-3 plays a critical role in suppressing protective immunity to P. berghei NK65 infection and that it is involved in inhibiting the development of splenomegaly, anemia, and erythropoiesis. IL-3 also influences IFN-γ, CXCL9, and G-CSF production in response to infection. The abnormal responses seen in infected IL-3 KO mice may be due to the lack of IL-3 during development, to the lack of IL-3 in the infected mature mice, or to both. 相似文献
106.
Morquio A Syndrome‐Associated Mutations: A Review of Alterations in the GALNS Gene and a New Locus‐Specific Database 下载免费PDF全文
Amelia Morrone Anna Caciotti Robert Atwood Kathryn Davidson Chaoyi Du Patricia Francis‐Lyon Paul Harmatz Matthew Mealiffe Sean Mooney Tal Ronnen Oron April Ryles Karl A. Zawadzki Nicole Miller 《Human mutation》2014,35(11):1271-1279
Morquio A syndrome (mucopolysaccharidosis IVA) is an autosomal recessive disorder that results from deficient activity of the enzyme N‐acetylgalactosamine‐6‐sulfatase (GALNS) due to alterations in the GALNS gene, which causes major skeletal and connective tissue abnormalities and effects on multiple organ systems. The GALNS alterations associated with Morquio A are numerous and heterogeneous, and new alterations are continuously identified. To aid detection and interpretation of GALNS alterations, from previously published research, we provide a comprehensive and up‐to‐date listing of 277 unique GALNS alterations associated with Morquio A identified from 1,091 published GALNS alleles. In agreement with previous findings, most reported GALNS alterations are missense changes and even the most frequent alterations are relatively uncommon. We found that 48% of patients are assessed as homozygous for a GALNS alteration, 39% are assessed as heterozygous for two identified GALNS alterations, and in 13% of patients only one GALNS alteration is detected. We report here the creation of a locus‐specific database for the GALNS gene ( http://galns.mutdb.org/ ) that catalogs all reported alterations in GALNS to date. We highlight the challenges both in alteration detection and genotype–phenotype interpretation caused in part by the heterogeneity of GALNS alterations and provide recommendations for molecular testing of GALNS. 相似文献
107.
108.
Nicole J. Mitchell Justice Kumi Mildred Aleser Sarah E. Elmore Kristal A. Rychlik Katherine E. Zychowski Amelia A. Romoser Timothy D. Phillips Nii-Ayi Ankrah 《The American journal of tropical medicine and hygiene》2014,90(4):777-780
Recently, an association between childhood growth stunting and aflatoxin (AF) exposure has been identified. In Ghana, homemade nutritional supplements often consist of AF-prone commodities. In this study, children were enrolled in a clinical intervention trial to determine the safety and efficacy of Uniform Particle Size NovaSil (UPSN), a refined calcium montmorillonite known to be safe in adults. Participants ingested 0.75 or 1.5 g UPSN or 1.5 g calcium carbonate placebo per day for 14 days. Hematological and serum biochemistry parameters in the UPSN groups were not significantly different from the placebo-controlled group. Importantly, there were no adverse events attributable to UPSN treatment. A significant reduction in urinary metabolite (AFM1) was observed in the high-dose group compared with placebo. Results indicate that UPSN is safe for children at doses up to 1.5 g/day for a period of 2 weeks and can reduce exposure to AFs, resulting in increased quality and efficacy of contaminated foods. 相似文献
109.
David Gilfillan Gordon Parker Elizabeth Sheppard Vijaya Manicavasagar Amelia Paterson Bianca Blanch Stacey McCraw 《Comprehensive psychiatry》2014
Objective
This paper seeks to determine the relevance and likely salience of cognitive behaviour therapy (CBT) as a treatment for melancholic depression.Methods
The findings of a randomised trial comparing 12-week outcome of 18 patients with melancholic depression receiving antidepressant medication and 11 receiving CBT were evaluated, and qualitative explanations for the outcomes were provided principally by the treating CBT practitioners.Results
In the trial, CBT showed no improvement in depression severity in the first four weeks and then some level of improvement over the subsequent eight weeks. Outcome was superior for those receiving antidepressant medication at 12 weeks and was first demonstrated at four weeks. The benefits of CBT appeared to be in settling anxiety, dealing with cognitive processing of having a melancholic depression and addressing any personality vulnerabilities.Conclusion
While a pilot study, our qualitative reports indicate that CBT may provide a useful role in managing melancholia as an adjunct to antidepressant medication. Future studies examining such a combination treatment model should seek to determine if indicative data provided here argue for a sequencing model of CBT being introduced after medication has addressed core biological underpinnings. 相似文献110.
Pengo V Banzato A Bison E Bracco A Denas G Ruffatti A 《Seminars in thrombosis and hemostasis》2012,38(4):322-327
Venous or arterial thrombosis or pregnancy morbidity in the presence of circulating antiphospholipid antibodies (aPL) define the antiphospholipid syndrome (APS). In terms of accepted APS criteria, aPL are detected by one coagulation test (lupus anticoagulant; LAC) and two immunoassays (anticardiolipin antibodies and anti-β2-glycoptrotein I antibodies). In patients with APS, a single positive test carries a much lower risk of thrombosis recurrence or new pregnancy loss than does multiple (or triple) positivity. The same holds true for aPL carriers, namely subjects with laboratory tests but without clinical criteria for APS. Thus, very different risk categories exist among patients with APS as well as in carriers of aPL. Triple positivity apparently identifies the pathogenic autoantibody (antidomain I-II of β2-glycoptrotein I); it is in this category of patients that trials on new therapeutic strategies should focus. 相似文献