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31.
Maite Domínguez Ayala Amaia Expósito Rodríguez Amaia Bilbao González Pablo Mínguez Gabiña Teresa Gutiérrez Rodríguez Emilia Rodeño Ortiz de Zarate Maitane García Carrillo Borja Barrios Treviño 《Cirugía espa?ola》2018,96(5):276-282
Introduction
The BRAF V600E mutation in papillary thyroid cancer (PTC) has been associated with resistance to 131I. Our aim was to quantify the response to 131I after surgery in patients who had the mutation (BRAF+) and those who did not have the mutated gene (BRAF?).Method
A prospective cohort study was designed, from September 2015 to February 2016, which included patients with PTC receiving therapy after surgical treatment. Variables were described for age, gender, histology, tumor stage, thyroglobulin values before, 48 h after and 6 months after 131I; absorbed dose and % activity on days 2 and 7 and elimination time.Results
41 patients giving in total 67 thyroid remnants were included. 61% were BRAF+. In stages iii and iv, 80% were BRAF+. In lateral resection, 100% were BRAF+. The number of nodes was higher in BRAF+: 3.4 vs 1.2 (P = .01). The classic variant was predominant in BRAF+ (91.7% vs 8.3%, P = .03). 85.7% vs 14.3% of BRAF+ had desmoplastic reaction (P = .02). The BRAF+ had a lower absorbed dose than the administered activity (5.4 Gy/MBq vs 20 Gy/MBq, P = .02); lower% activity with respect to the unit of mass at 2 (0.046%/g vs 0.103%/g, P = .02) and at 7 days (0.006%/gr vs 0.034%/gr, P = .04)Conclusions
The mutation of the BRAF V600E gene is related with greater resistance to postoperative treatment with 131I since the onset of the disease. 相似文献32.
33.
Compromised muscle function can be evaluated in respiratory disease patients by supramaximal magnetic stimulation (isometric twitch) of the quadriceps, a technique that is reproducible and objective. We validated the technique, comparing a device used in our laboratory with another reference electromagnet. We also assessed whether the technique could potentially be used to train the muscle by repetitive stimulation. The Medtronic Magpro (MED) device with a circular coil and the Magstim 200 device (MAG) with a figure-of-eight coil (reference device) were used to stimulate the femoral nerve of 6 volunteers at different percentages of maximal output. MED stimulation was also applied on the quadriceps muscle. We measured voluntary contractions, comparing measurements from the 2 devices and on different days. The stimulation achieved with MED was lower than with MAG, showed greater day-to-day variability, and was not clearly supramaximal. MED quadriceps stimulation was 80.7% of MAG stimulation. In conclusion, supramaximal stimulation of the quadriceps cannot be guaranteed with MED and the circular coil. However, this device generates sufficient contraction when applied to the muscle to be used for repetitive stimulation. 相似文献
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Nuno Maia Nekane Ibarluzea Mala Misra-Isrie Daniel C. Koboldt Isabel Marques Gabriela Soares Rosário Santos Carlo L. M. Marcelis Riikka Keski-Filppula Miriam Guitart Elisabeth Gabau Vila April Lehman Scott Hickey Mari Mori Paulien Terhal Irene Valenzuela Amaia Lasa-Aranzasti Anna Maria Cueto-González Brian H. Chhouk Rebecca C. Yeh Jennifer E. Neil Bassam Abu-Libde Tjitske Kleefstra Mariet W. Elting Andrea Császár Judit Kárteszi Beáta Bessenyei Hans van Bokhoven Paula Jorge Johanna M. van Hagen Arjan P. M. de Brouwer 《American journal of medical genetics. Part A》2023,191(1):135-143
We describe the phenotype of 22 male patients (20 probands) carrying a hemizygous missense variant in MED12. The phenotypic spectrum is very broad ranging from nonspecific intellectual disability (ID) to the three well-known syndromes: Opitz–Kaveggia syndrome, Lujan–Fryns syndrome, or Ohdo syndrome. The identified variants were randomly distributed throughout the gene (p = 0.993, χ2 test), but mostly outside the functional domains (p = 0.004; χ2 test). Statistical analyses did not show a correlation between the MED12-related phenotypes and the locations of the variants (p = 0.295; Pearson correlation), nor the protein domain involved (p = 0.422; Pearson correlation). In conclusion, establishing a genotype–phenotype correlation in MED12-related diseases remains challenging. Therefore, we think that patients with a causative MED12 variant are currently underdiagnosed due to the broad patients' clinical presentations. 相似文献
36.
Gómez-Ambrosi J Salvador J Rotellar F Silva C Catalán V Rodríguez A Jesús Gil M Frühbeck G 《Obesity surgery》2006,16(3):262-269
Background: Obesity is considered a state of low-grade chronic inflammation, which may favor the development of cardiovascular
diseases. Serum amyloid A (SAA) is an acute phase protein synthesized in response to infection, inflammation, injury, and stress. The aim of the present
study was to compare the circulating concentrations of SAA and the mRNA expression in omental adipose tissue between lean
and obese individuals and to analyze the effect of weight loss after gastric bypass. Methods: 16 lean volunteers (BMI 20.5
± 0.6 kg/m2) and 24 obese patients (BMI 47.0 ± 1.2 kg/m2) were included in the study. Serum concentrations of SAA were measured by ELISA. In addition, the concentrations of SAA in
18 morbidly obese patients (7 male/11 female; BMI 44.6 ± 1.9 kg/m2) were measured before and after weight loss following Roux-en-Y gastric bypass (RYGBP). SAA expression in omental adipose
tissue was quantified by RT-PCR in biopsies from obese patients undergoing RYGBP and from age-matched lean individuals subjected
to Nissen fundoplication. Results: Obese patients exhibited significantly increased circulating SAA concentrations (6.6 ±
0.5 vs 39.3 ± 9.1 μg/ml; P<0.01) compared to lean subjects. A significant positive correlation was found between logSAA and body fat (r=0.631, P<0.0001). Obese patients showed significantly increased (P<0.05) mRNA expression of SAA in omental adipose tissue compared to lean subjects. Weight loss significantly decreased SAA
concentrations after RYGBP (final BMI 28.5 ± 0.9 kg/m2, P<0.0001 vs initial) from 47.5 ± 14.5 to 15.7 ± 2.9 μg/ml (P<0.05). Conclusion: It can be concluded that serum SAA and mRNA expression of SAA in omental adipose tissue are increased
in obese patients contributing to the obesity-associated cardiovascular disease risk. Moreover, weight loss reduces SAA concentrations,
which may contribute to the beneficial effects accompanying weight reduction. 相似文献
37.
38.
Gorka Larrinaga Lorena Blanco Peio Errarte Maider Beitia Bego?a Sanz Itxaro Perez Amaia Irazusta Clara E. Sánchez Francisco Santaolalla Leire Andrés José I. López 《Disease markers》2013,35(6):825-832
Background. Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland. Methods. The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues. Results. The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH. Conclusions. These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms. 相似文献
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