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101.
Early postnatal growth and neurodevelopment in children born moderately preterm or small for gestational age at term: A systematic review
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102.
Lartigue MF Zinsius C Wenger A Bille J Poirel L Nordmann P 《Antimicrobial agents and chemotherapy》2007,51(8):2855-2860
The epidemiology of clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) was investigated among infection-associated enterobacterial isolates at the University Hospital in Lausanne, Switzerland, from January 2004 to June 2005. Out of 57 nonrepetitive ESBL producers (prevalence rate of 0.7%), 45 produced CTX-M-like ESBLs. CTX-M enzymes were mostly from clonally nonrelated Escherichia coli isolates, from urinary infections and community-acquired infections. Pediatric patients (20 out of 57) accounted for a large number of CTX-M producers. CTX-M-15 was the most frequent CTX-M-type enzyme. The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland. 相似文献
103.
Marzano Lucas Alexandre Santos Batista Joao Pedro Thimotheo de Abreu Arruda Marina de Freitas Cardoso Mara Glria de Barros Joo Lus Vieira Monteiro Moreira Janana Matos Liu Priscila Menezes Ferri Teixeira Antnio Lcio Simes e Silva Ana Cristina de Miranda Aline Silva 《Neurosurgical review》2022,45(1):167-197
Neurosurgical Review - Traumatic brain injury (TBI) is the main cause of pediatric trauma death and disability worldwide. Recent studies have sought to identify biomarkers of TBI for the purpose of... 相似文献
104.
Riechardt Aline I. Stroux Andrea Seibel Ira Heufelder Jens Zeitz Oliver Böhmer Dirk Joussen Antonia M. Gollrad Johannes 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(11):2523-2533
Graefe's Archive for Clinical and Experimental Ophthalmology - To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic... 相似文献
105.
Bárbara Abrahim-Vieira Emmerson C. B. da Costa Pedro H. R. de A. Azevedo Aline C. Portela Luiza R. S. Dias Sergio Pinheiro Amilcar Tanuri Anne M. Capaccia Gustavo T. Ventura Ronaldo Mohana-Borges Carlos R. Rodrigues Alessandra M. T. de Souza Estela M. F. Muri 《Medicinal chemistry research》2014,23(12):5305-5320
Hepatitis C viral infection is a cause of chronic liver disease, and current therapies are only effective in 50 % of patients. Serine proteases, which are present in both hepatitis C virus (HCV) and the dengue virus, are the most studied class of proteolytic enzymes and are the primary targets for drug development in this field. In this paper, we describe the synthesis of a novel class of isomannide-based peptide mimetic compounds based on a tartaric acid backbone. Our data showed that substitutions at position 168 (D168A) and 170 (V170A) conferred low-level resistance against compound 5a3, whereas substitutions at position 155 (R155K) and 156 (A156V) conferred no resistance. These data suggest that even though compound 5a3 is a noncompetitive inhibitor; it is able to interact with important residues located near the catalytic site. In addition, this novel compound class exhibits potent antiviral activity against variants carrying resistance mutations to boceprevir and telaprevir. Our docking studies showed important interactions, including hydrogen bonds and a π–π interaction, between compound 5a3 and residues of the allosteric site of NS3/4A. Biological and theoretical results indicate that 5a3 is a promising lead compound for the development of new drugs targeting HCV infection. 相似文献
106.
Aline Moraes MENACHO Adriano REIMANN Lie Mara HIRATA Caroline GANZERELLA Flavio Heuta IVANO Ricardo SUGISAWA 《Brazilian archives of digestive surgery》2014,27(1):9-12
Background
Colonoscopy is the most frequent exam used to evaluate colonic mucosa, allowing the diagnosis and treatment of many diseases. The appropriate bowel preparation is indispensable for the realization of colonoscopy. Therefore, it is necessary the use of laxative medications, preferentially by oral administration.Aim
To compare two medications used in bowel preparation in adult patients going to ambulatory colonoscopy and to analyze the patients'' profile.Methods
A double-blind prospective study with 200 patients, randomized in two groups: one that received polyethilene glycol and another that received lactulose. The patients answered to questionnaires to data compilation, as tolerance, symptoms and complications related to preparation. Besides, it was also evaluated the prepare efficacy related to the presence of fecal residue.Results
Intestinal habit alterations and abdominal pain were the main reasons to realize the exams and hypertension was the most prevalent comorbidity. Ten percent of the ones who received lactulose didn''t get to finish the preparation and 50% considered the taste "bad, but tolerable". The most common subjective symptom after the medication was nausea, especially after lactulose. During the exam, most of the patients who used lactulose had a "light discomfort" and the ones who used polyethilene glycol considered the discomfort as "tolerable". The quality of the preparation was good in 75%, undependable of the medication that was used.Conclusion
Polyethilene glycol was more tolerable when compared to lactulose, without difference on the quality of the preparation. 相似文献107.
Margot Fournier Carina Ferrari Philipp S. Baumann Andrea Polari Aline Monin Tanja Bellier-Teichmann Jacob Wulff Kirk L. Pappan Michel Cuenod Philippe Conus Kim Q. Do 《Schizophrenia bulletin》2014,40(5):973-983
Because increasing evidence point to the convergence of environmental and genetic risk factors to drive redox dysregulation in schizophrenia, we aim to clarify whether the metabolic anomalies associated with early psychosis reflect an adaptation to oxidative stress. Metabolomic profiling was performed to characterize the response to oxidative stress in fibroblasts from control individuals (n = 20) and early psychosis patients (n = 30), and in all, 282 metabolites were identified. In addition to the expected redox/antioxidant response, oxidative stress induced a decrease of lysolipid levels in fibroblasts from healthy controls that were largely muted in fibroblasts from patients. Most notably, fibroblasts from patients showed disrupted extracellular matrix- and arginine-related metabolism after oxidative stress, indicating impairments beyond the redox system. Plasma membrane and extracellular matrix, 2 regulators of neuronal activity and plasticity, appeared as particularly susceptible to oxidative stress and thus provide novel mechanistic insights for pathophysiological understanding of early stages of psychosis. Statistically, antipsychotic medication at the time of biopsy was not accounting for these anomalies in the metabolism of patients’ fibroblasts, indicating that they might be intrinsic to the disease. Although these results are preliminary and should be confirmed in a larger group of patients, they nevertheless indicate that the metabolic signature of reactivity to oxidative stress may provide reliable early markers of psychosis. Developing protective measures aimed at normalizing the disrupted pathways should prevent the pathological consequences of environmental stressors.Key words: mental disorder, glutathione, arginine, extracellular matrix, phospholipid, metabolism 相似文献
108.
Assessment of the genotoxic and carcinogenic potentials of 3‐aminothiophene derivatives using in vitro and in silico methodologies
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Alban Lepailleur Ronan Bureau Marie‐Pierre Halm‐Lemeille Michel Bouquet Régis Pecquet Christine Paris‐Soubayrol Jérémie Le. Goff Véronique André Yannick Lecluse Pierre Lebailly Marie‐Aline Maire Paule Vasseur 《Journal of applied toxicology : JAT》2014,34(7):775-786
Thiophene derivatives, a class of compounds widely used in products such as pharmaceuticals, agrochemicals or dyestuffs, represent chemicals of concern. Indeed, the thiophene ring is often considered as a structural moiety that may be involved in toxic effects in humans. We primarily focus on the genotoxic/mutagenic and carcinogenic potentials of the methyl 3‐amino‐4‐methylthiophene‐2‐carboxylate (1), a precursor of the articaine local anesthetic (4) which falls within the scope of the European REACH (Registration, Evaluation, Authorisation and restriction of CHemicals) legislation. To discern some structure–toxicity relationships, we also studied two related compounds, namely the 3‐amino 4‐methylthiophene (2) and the 2‐acetyl 4‐chlorothiophene (3). Techniques employed to assess mutagenic and DNA‐damaging effects involved the Salmonella mutagenicity assay (or Ames test) and the single‐cell gel electrophoresis assay (or Comet assay). In the range of tested doses, none of these derivatives led to a positive response in the Ames tests and DNA damage was only observed in the Comet assay after high concentration exposure of 2. The study of their carcinogenic potential using the in vitro SHE (Syrian Hamster Embryo) cell transformation assay (CTA) highlighted the activity of compound 2. A combination of experimental data with in silico predictions of the reactivity of thiophene derivatives towards cytochrome P450 (CYP450), enabled us to hypothesize possible pathways leading to these toxicological profiles. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
109.
Judith Wemmer Loredana Malafronte Socrates Foschini Aline Schneider Christian M. Schlepütz Martin E. Leser Martin Michel Adam Burbigde Erich J. Windhab 《Materials》2021,14(9)
An open-porous protein sponge with mixed wettability is presented made entirely from whey proteins and with promising applications in biomedicine, pharmaceutical, and food industry. The fabrication relies on an additive-free, clean and scalable process consisting of foaming followed by controlled microwave-convection drying. Volumetric heating throughout the matrix induced by microwaves causes fast expansion and elongation of the foam bubbles, retards crust formation and promotes early protein denaturation. These effects counteract collapse and shrinkage typically encountered in convection drying of foams. The interplay of high protein content, tailored gas incorporation and controlled drying result in a dried structure with dual-scale porosity composed of open macroscopic elongated foam bubbles and microscopic pores in the surrounding solid lamellae induced by water evaporation. Due to the insolubility and mixed wettability of the denatured protein network, polar and non-polar liquids are rapidly absorbed into the interconnected capillary system of the sponge without disintegrating. While non-watery liquids penetrate the pores by capillary suction, water diffuses also into the stiff protein matrix, inducing swelling and softening. Consequently, the water-filled soft sponge can be emptied by compression and re-absorbs any wetting liquid into the free capillary space. 相似文献
110.
Marcelo Carvalho Vieira Fernanda de Souza Nogueira Sardinha Mendes Flavia Mazzoli-Rocha Rudson Santos Silva Aline Maria Nunes Viana Aline Xavier Frota Gilberto Marcelo Sperandio da Silva Paula Simplício da Silva Alejandro Marcel Hasslocher-Moreno Roberto Magalhães Saraiva Andrea Silvestre de Sousa Mauro Felippe Felix Mediano 《Tropical medicine & international health : TM & IH》2021,26(3):355-365