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991.
Pennell RG; Baltarowich OH; Kurtz AB; Vilaro MM; Rifkin MD; Needleman L; Mitchell DG; Mervis SA; Goldberg BB 《Radiology》1987,165(1):79-83
Endovaginal ultrasound (US) was performed in 38 pregnant women at 5-12 menstrual weeks, when the initial transabdominal sonograms had been considered inconclusive or equivocal. Clinical follow-up disclosed 32 intrauterine pregnancies (12 living, 18 spontaneous incomplete abortions, and two embryonic demises) and six ectopic pregnancies. In the 32 intrauterine pregnancies (normal and abnormal), the correct diagnosis was made in all cases with endovaginal US. The endovaginal images demonstrated the intrauterine embryo, its heart motion, and the yolk sac more clearly and more often when these structures were not apparent on the transabdominal scans. Abnormal gestational sacs were better resolved. In the six cases of ectopic pregnancy, while an extrauterine ectopic sac was visualized in only three, absence of an intrauterine gestational sac was confirmed in all cases with endovaginal scanning. No endovaginal study yielded less information than its transabdominal counterpart. Endovaginal sonography is likely to be diagnostic when transabdominal images fail to yield a definitive diagnosis in early pregnancies. 相似文献
992.
Wahl DG; De Maistre E; Guillemin F; Regnault V; Perret-Guillaume C; Lecompte T 《QJM : monthly journal of the Association of Physicians》1998,91(2):125-130
We studied the prognostic significance of antiphospholipid antibodies for
recurrence of venous thromboembolism (VTE), in 71 patients admitted for
acute VTE (deep-vein thrombosis or pulmonary embolism) in a single internal
medicine unit. Lupus anticoagulant (LA), antibodies directed against beta
2-glycoprotein I (beta 2GPI) and antibodies against both beta 2GPI and a
mixture of phospholipids (cardiolipin, phosphatidylserine and phosphatidic
acid) (APAs) were measured. The patients were followed-up (mean 4.9 years)
to determine the time to the next VTE. We found LA in nine patients,
anti-beta 2GPI antibodies in seven patients and APAs in six patients. The
cumulative risk of recurring VTE was higher in patients with beta
2GPI-binding antibodies (hazard ratio 12.6, 95% CI 1.5-104.9; p = 0.0029).
The risk associated with APAs was 11.5 (95% CI 1.3-98.9; p = 0.0049) and
that for LA was 3.7 (95% CI 0.9-15.6; p = 0.055). The risk of VTE recurring
was higher both in patients with antibodies directed against beta 2GPI, and
in patients with antibodies directed against beta 2GPI and a mixture of
phospholipids, than in patients without these antibodies.
相似文献
993.
A benzidine-derived azo dye, C.I. direct black 38 (DB38), and a p-phenylenediamine-derived dye, C.I. direct black 19 (DB19), labeled with carbon-14 in their aromatic amine moieties, were applied to the shaved dorsal skin of male Fischer-344 rats and New Zealand rabbits. Application sites were protected with nylon gauze and elastic bandage assemblies. Following application of measured amounts of radiolabeled dye in 0.1 M pH 10.2 carbonate buffer, serial urine and fecal samples were obtained from individual animals in metabolism cages at 24, 48, 72, 96, 120, and 144 h. Aliquots of urine and fecal homogenates were assayed for radioactivity by scintillation counting. Cumulative excretion of radioactivity from rats receiving DB38 was 0.05% of total dermal dose at 144 h in urine, and 0.16% of total dermal dose in feces. Cumulative excretion of radioactivity from DB38-treated rabbits at 144 h was 3.12% of total dermal dose in urine, and 5.12% in feces. From rats and rabbits receiving topical DB19, cumulative excretion of radioactivity at 144 h was less than that from DB38-treated animals. In rat urine, 0.04% of total dermal dose appeared; in rat feces, no radioactivity was recovered. In rabbit urine, 0.04% of dermal dose was found; 0.01% appeared in rabbit feces. 相似文献
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996.
Polysomnographic assessment of insomnia 总被引:7,自引:0,他引:7
M S Aldrich 《Sleep》1990,13(2):188-9, 191-2
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999.
Triozzi PL Aldrich W Allen KO Lima J Shaw DR Strong TV 《International journal of cancer. Journal international du cancer》2005,113(3):406-414
Deficiency in costimulatory molecule expression has been implicated in the ability of tumors to escape immune effectors. The activity of the intratumoral administration of recombinant fowlpox vectors expressing a triad of costimulatory molecules (rF-TRICOM) was evaluated in the asbestos-induced AB12 and AC29 mouse models of mesothelioma. Mesothelioma cell infected with rF-TRICOM expressed high levels of the costimulatory molecules. Prolongation of survival was observed in mice receiving rF-TRICOM in AB12 and AC29 intraperitoneal models. Complete tumor regressions were observed in mice receiving intratumoral rF-TRICOM in the AB12 subcutaneous tumor model. Tumor regressions were associated with the development of serum IgG reactivities to mesothelioma-associated determinants and specific systemic cytolytic activity, and responding mice were capable of rejecting tumors upon re-challenge. Antitumor activity was also observed in mice with established AB12 tumor vaccinated with irradiated rF-TRICOM-infected AB12 cells. The antitumor activity of intratumoral rF-TRICOM was superior to that of the intratumoral injection of a fowlpox vector expressing granulocyte-macrophage colony stimulating factor (rF-GM-CSF). AB12 and AC29 tumors were found to produce GM-CSF and to have substantial macrophage infiltration. Production of GM-CSF decreased in vivo in tumors injected with rF-TRICOM. rF-TRICOM and wild-type fowlpox inhibited the growth of AB12 and AC29 cells in vitro; less inhibition was observed with rF-GM-CSF. These results indicate that the intratumoral injection of rF-TRICOM has significant activity in mouse models of mesothelioma and can elicit a systemic antitumor immune response. The results also suggest potential limitations to the intratumoral administration of cytokines, such as GM-CSF, in mesothelioma. 相似文献
1000.