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41.
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The clofibric acid (CPIB) concentration in the rat blood plasma during 14 days of treatment with clofibrate and after cessation of the treatment, was measured and compared with the changes of some NADP-linked dehydrogenases activity. CPIB rapidly accumulates in the plasma during the first two days of clofibrate administration reaching a maximum concentration of about 0.6 mM. Then a linear decrease of the drug concentration was observed. The second day after clofibrate treatment had been completed, CPIB could no longer be detected in the plasma. Liver malic enzyme activity increased constantly up to the third day after cessation of the treatment. There was a decrease of activity which reached its control level on the 32nd day of the experiment. The variation patterns of hexose monophosphate shunt dehydrogenases activity and liver weight were similar to the changes of malic enzyme activity. 相似文献
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W Peczyńska-Czoch M Mordarski L Kaczmarek P Nantka-Namirski 《Archivum immunologiae et therapiae experimentalis》1987,35(2):89-95
Microbial transformation of selected azacarbazoles, compounds noted for their activity as antitumor agents, conducted with Kitasatosporia setae strain resulted in N-methylation of pyridine nucleus of alpha-, beta- and gamma-carboline molecule. Formed quaternized intermediates were converted in alkaline conditions into corresponding iso-carbolines. The structure of the final products, alpha-, beta- and gamma-iso-carbolines have been established on the basis of spectral data and confirmed by chemical synthesis. 相似文献
47.
The paper presents the possibilities of applying the posterior thigh flap in the treatment of ischial pressure sores. Between 2000 and 2004 the flap was used in three cases treated in the Orthopaedics and Traumatology Department of the Medical Universtity in Bialystok. The indications, contraindications, operative technique and advantages of the posterior thigh flap are described. In all three cases the ischial bed sores healed well without recurrences. The posterior fasciocutaneous pedicled flap is a good method of treatment for not too extensive bed sores in the ischial region.This flap can be applied in recurrences found after primary bed sore treatment with another method. However the fasciocutaneous flap has a limited range of transposition as compared with cutaneous flaps. 相似文献
48.
Violence at the workplace--a questionnaire survey of nurses. 总被引:2,自引:0,他引:2
Dorota Merecz Joanna Rymaszewska Agnieszka Mo?cicka Andrzej Kiejna Joanna Jarosz-Nowak 《European psychiatry》2006,21(7):442-450
BACKGROUND: In the health sector, anywhere in the world nurses are one of the most exposed groups to violence. However, it is not obvious that psychiatric nurses (PNs) are more exposed to aggression and burnout. OBJECTIVES: To determine the nature and effects of aggressive acts towards nursing staff in psychiatric and other medical services in Poland. METHODS: Various questionnaires (Stress at Work Scale, General Health Questionnaire, Maslach Burnout Inventory, Work Satisfaction Scale), were distributed among psychiatric (N=78) and non-psychiatric nurses (N-PNs) (N=335). A 92.6% response rate was achieved. RESULTS: Significant differences were found between PNs and non-psychiatric counterparts with respect to their experiences of violence. The most frequently reported incident was verbal abuse, followed by threats and physical assault. Patients were significantly more frequent perpetrators in psychiatric wards than in others. The level of intra-staff aggression did not significantly vary between groups, neither did the level of work satisfaction and absenteeism. CONCLUSION: The frequency of violent acts and stress related to them point out the strong need for the development of preventive programs to address the issue of violence at work. 相似文献
49.
A Zejc J Obniska M Wilimowski M Rutkowská M Witkowska J Barczyńska L Kedzierska-Go?dzik W Wojewódzki K Orzechowska-Juzwenko T P?awiak 《Polish journal of pharmacology and pharmacy》1990,42(1):69-77
In reaction of alpha-phenyl, alpha-p-chlorophenyl and alpha-m-chlorophenylsuccinic acid with various aminopyridines, N-pyridyl-substituted succinimides (compounds 1-14) were obtained. These compounds were investigated for their CNS activity. Compounds 1, 2, 5, 6 and 7 displayed anticonvulsant properties in the maximum electroshock test. Compounds 5 and 6 were also active in the pentetrazole test. 相似文献
50.