全文获取类型
收费全文 | 4444篇 |
免费 | 183篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 193篇 |
妇产科学 | 213篇 |
基础医学 | 696篇 |
口腔科学 | 33篇 |
临床医学 | 266篇 |
内科学 | 999篇 |
皮肤病学 | 69篇 |
神经病学 | 388篇 |
特种医学 | 69篇 |
外科学 | 198篇 |
综合类 | 26篇 |
预防医学 | 373篇 |
眼科学 | 118篇 |
药学 | 597篇 |
中国医学 | 15篇 |
肿瘤学 | 283篇 |
出版年
2024年 | 7篇 |
2023年 | 31篇 |
2022年 | 203篇 |
2021年 | 303篇 |
2020年 | 107篇 |
2019年 | 134篇 |
2018年 | 145篇 |
2017年 | 130篇 |
2016年 | 154篇 |
2015年 | 154篇 |
2014年 | 205篇 |
2013年 | 286篇 |
2012年 | 366篇 |
2011年 | 373篇 |
2010年 | 199篇 |
2009年 | 149篇 |
2008年 | 240篇 |
2007年 | 313篇 |
2006年 | 278篇 |
2005年 | 261篇 |
2004年 | 193篇 |
2003年 | 186篇 |
2002年 | 146篇 |
2001年 | 15篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 11篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1981年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1968年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有4639条查询结果,搜索用时 15 毫秒
81.
Ewa Brojer Katarzyna Guz Agnieszka Orzińska Monika Pelc-Kłopotowska Bogumiła Michalewska 《Acta haematologica Polonica》2013,44(3):260-264
One of the basic rules of transfusion is to prevent alloimmunisation by highly immunogenic RhD antigen and not to transfuse RhD negative individuals with RhD positive blood. In some cases the expression of this antigen is so weak that it is undetectable in routine serological tests. The paper presents an algorithm for mass DNA testing with the purpose of identifying donors with low RhD expression. The screening is based on RHD gene detection (absent in RhD negative Caucasians) in DNA isolated from pools of 96 plasma samples from blood donors identified as RhD negative by the routine serological methods in Blood Transfusion Centers. Such procedure substantially reduces the costs. Plasma samples can be brought from the territory of the whole country, stored and accumulated for testing in one selected center. The cost would amount to approximately 25 PLN per donor. The test is performed once for each RhD negative individual. It is estimated that such persons will represent approximately 0.2% of RhD negative donors. 相似文献
82.
Wojciech Jurczak Simon Rule Peter Martin Rebecca Auer Brad S. Kahl Agnieszka Giza Bożena Jachimczak Ranjana H. Advani Jorge Romaguera Michael Williams Jacqueline Barrientos Ewa Chmielowska John Radford Stephan Stilgenbauer Jesse McGreivy Fong Clow Darrin M. Beaupre Lori Kunkel Michael L. Wang 《Acta haematologica Polonica》2013,44(3):314-318
Bruton's tyrosine kinase (BTK) is a central mediator of B-cell receptor (BCR) signaling essential for normal B-cell development. Ibrutinib is an oral BTK inhibitor that induces apoptosis and inhibits migration and adhesion of malignant B-cells. Updated results of this international, multicenter, phase 2 study of single agent ibrutinib in relapsed or refractory MCL will be presented.Ibrutinib 560 mg PO QD was administered continuously until disease progression. Tumor response was assessed every 2 cycles (one cycle = 28 days). The study enrolled 115 patients (65 bortezomib-naïve, 50 bortezomib-exposed); 111 patients were treated; 110 were evaluable for response. Baseline characteristics included: median age 68 years, time since diagnosis 42 months, number of prior treatments 3; bulky disease (>10 cm) 13%, prior stem cell transplant 10%, high risk MIPI 49%.Median time on treatment was 9.2 months; 53% of patients remain on therapy. Median PFS was 13.9 months and DOR has not yet been reached. Responses increased with longer treatment: comparing to previous data described at ASH 2011, the CR rate increased from 16% to 39%, and the ORR increased from 69% to 75%. 相似文献
83.
Teresa Grzelak Marta Tyszkiewicz-Nwafor Agata Dutkiewicz Aniceta Ada Mikulska Monika Dmitrzak-Weglarz Agnieszka Slopien Krystyna Czyzewska Elzbieta Paszynska 《Archives of Medical Science》2021,17(2):376
IntroductionThe aim of the study was to evaluate the correlation between the nutritional status of patients with anorexia nervosa (AN) and levels of vaspin (VASP), neuropeptide B (NPB), neuropeptide W (NPW) and total antioxidant status (TAS).Material and methodsNinety serum samples collected from 30 teenage female patients during the acute stage of AN and 30 healthy persons (CONTR) were subjected to biochemical analysis; patients with AN were examined at the beginning of the study (AN-I) and after hospitalization (AN-II), as a result of which partial stabilization of anthropometric measurements was achieved (an increase of body mass index (BMI) by 3.5 kg/m2).ResultsVaspin levels dropped at the end of the hospitalization (compared to AN-I, p < 0.05), achieving values comparable to the CONTR; moreover there was a positive correlation between VASP level and the achieved body weight in AN-II (p < 0.05). Positive correlations were also noted with regard to VASP vs. NPB in AN-I (p < 0.02) (and AN-II, p < 0.013), as well as in the case of VASP vs. NPW in the same groups (p < 0.02 and p < 0.015, respectively). NPB concentration was higher in AN-I (p < 0.05) and AN-II (p < 0.018) than in CONTR, whereas there were no differences (p > 0.05) with regard to levels of VASP, NPW, or TAS.ConclusionsThe high level of NPB despite treatment and normalization of VASP level may suggest that there are chronic neuroendocrine disorders at play in anorexia nervosa. 相似文献
84.
Magorzata Mizerska-Wasiak Dominika Adamczuk Karolina Cicho-Kawa Monika Miklaszewska Hanna Szymanik-Grzelak Jacek A. Pietrzyk Agnieszka Pukajo-Marczyk Danuta Zwoliska Agnieszka Rybi-Szumiska Anna Wasilewska Beata Bienia Przemysaw Sikora Agnieszka Firszt-Adamczyk Roman Stankiewicz Maria Szczepaska Magorzata Paczyk-Tomaszewska 《Archives of Medical Science》2021,17(1):84
IntroductionImmunoglobulin A nephropathy (IgAN) may lead to end stage renal disease and severely affect patient functioning and wellbeing. The aim of the study was to evaluate health-related quality of life (HRQoL) in children and adolescents with IgAN, and compare HRQoL in relation to the disease course, social status and psychological factors, such as expressing anger and perceived personal competence.Material and methodsThe multicentre cross-sectional study included 51 patients ≥ 8 years from 7 paediatric nephrology centres in Poland. Psychometric analysis was performed using the Kidscreen-52 questionnaire to evaluate HRQoL, the Anger Expression Scale to evaluate the severity of anger and the Personal Competence Scale to measure general perception of personal competence.ResultsMean age of patients was 14.54 ±3.69 years; duration since the diagnosis of IgAN was 4.98 ±3.9 years. Patients with IgAN rated their psychological wellbeing as significantly worse compared to healthy peers (p < 0.05). The presence of proteinuria was associated with significantly worse physical wellbeing (58.72 ±18.45 vs. 74.44 ±22.97; p < 0.05). Current therapy (steroids/immunosuppressive drugs) had no effect on HRQoL in the study group. Perceived personal competence was rated high by 49% of children in the study group. Children with IgAN were characterized by lower intensity of expressed anger (p < 0.001) and significantly higher intensity of suppressed anger (p < 0.01) compared to reference ranges. Severity of expressed anger correlated positively with the parent relations and school environment dimensions of HRQoL.ConclusionsWe found lower HRQoL in regard to physical and psychological wellbeing in a group of Polish children with IgAN compared to healthy peers. HRQoL should be monitored in this patient group. 相似文献
85.
Pawe Skowronek Artur Wojciechowski Krzysztof Wypniewski Marcin Sibiski Micha Polguj Agnieszka Maksymiuk-Kos Pawe Pitkiewicz 《Archives of Medical Science》2021,17(1):106
IntroductionPrimary arthroplasty of the hip joint is currently one of the most commonly performed procedures in orthopedics. In Poland we are observing significant changes in the age structure. With the prolonged life more and more elderly patients require musculoskeletal surgery to maintain comfortable and painless mobility. Reducing the duration of the procedure reduces the costs of anesthesiology, surgical and instrument teams, as well as the operating room technical team. The aim of the study was to compare the time required to perform hip joint arthroplasty by the direct anterior approach (DAA) with the postero-lateral approach (PLA) in our hospital.Material and methodsA retrospective analysis of 559 total and bipolar cemented and cementless hip replacement procedures based on two operative approaches – the minimally invasive DAA over the course of 2 years, and the standard PLA over the course of 3 years – was performed.ResultsStatistically significant differences were observed between the approaches used for cementless total arthroplasty with regard to the mean treatment times: 51.9 min for the 272 DAA cases, and 78.3 min for the 190 PLA cases (p < 0.0001). For the cementless hemi-arthroplasty procedure, the mean treatment times were 46.9 min in 36 patients for DAA, and 48.2 min for 61 patients for PLA (p = 0.57).ConclusionsMinimally invasive DAA significantly shortens the time of the procedure in elderly patients compared to PLA. Further study is needed to analyze other aspects of those two approaches. 相似文献
86.
Agnieszka Pluta Tadeusz Robak Barbara Cebula Agata Majchrzak Piotr Pluta Kamil Brzozowski Konrad Stpka Anna Szmigielska-Kapon Olga Grzybowska-Izydorczyk Magdalena Czemerska Piotr Smolewski Agnieszka Wierzbowska 《Archives of Medical Science》2021,17(3):700
IntroductionThe misbalance between a family of inhibitor of apoptosis proteins (IAP), regulated by the nuclear factor kappa B (NF-κB) and their natural antagonist second mitochondrial-derived activator of caspases/direct IAP binding protein with low pI (Smac/DIABLO) are important to biology of acute myeloid leukemia (AML).Material and methodsThe aim of the study was to assess NF-κB and Smac/DIABLO proteins expression in blasts of 109 newly diagnosed AML patients using the multicolor flow cytometry and evaluate their influence on AML patients outcome.ResultsExpression of NF-κB and of Smac/DIABLO proteins were found in 95% and 98% of the patients, respectively. A negative correlation between Smac/DIABLO and NF-κB was observed. Age < 60 years old as well as higher Smac/DIABLO expression were associated with a higher probability of complete response achievement in the multivariate analysis. Longer overall survival (OS) in the univariate and multivariate analyses was influenced by age < 60 years old, a favorable or intermediate-risk karyotype and high Smac/DIABLO expression. Additionally, in the survival analysis of the subgroups, the patients aged < 60 years old, with high Smac/DIABLO expression, lower NF-κB expression and < 50% of bone marrow blasts who were treated with standard treatment had better OS.ConclusionsLower NF-κB and higher Smac/DIABLO expression may influence AML patients outcome. 相似文献
87.
Ccile Toly‐Ndour Stphanie Huguet‐Jacquot Agns Mailloux Hlne Delaby Giorgia Canellini Martin L. Olsson Agneta Wikman Joke M. Koelewijn Jean‐Marc Minon Tobias J. Legler Frederik B. Clausen Mark Lambert Helen Ryan Irena Bricl Sys Hasslund Agnieszka Orzinska Katarzyna Guz Malgorzata Uhrynowska Antonella Matteocci Nuria Nogues Eduardo Muniz‐Diaz Susanna Sainio Masja De Haas C. Ellen Van der Schoot 《ISBT科学丛刊》2021,16(1):106-118
88.
89.
Agnieszka Pron Philippe Berrouard Mario Leclerc 《Macromolecular chemistry and physics.》2013,214(1):7-16
Over the last decade, great progress has been made in the field of organic electronics. Advancements in organic syntheses as well as in device engineering enabled preparation of polymer solar cells with power conversion efficiency (PCE) exceeding 8%–9%. In search for new polymers suitable for photovoltaic applications, push–pull polymers containing thieno[3,4‐c]pyrrole‐4,6‐dione (TPD) motif as an electron deficient (pull) unit emerged as very promising candidates. This Trend Article summarizes research on TPD‐based polymers with a special emphasis on the structure–property relationships. 相似文献