全文获取类型
收费全文 | 2694篇 |
免费 | 306篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 93篇 |
妇产科学 | 93篇 |
基础医学 | 270篇 |
口腔科学 | 187篇 |
临床医学 | 234篇 |
内科学 | 672篇 |
皮肤病学 | 37篇 |
神经病学 | 99篇 |
特种医学 | 67篇 |
外科学 | 331篇 |
综合类 | 73篇 |
预防医学 | 285篇 |
眼科学 | 147篇 |
药学 | 231篇 |
中国医学 | 11篇 |
肿瘤学 | 158篇 |
出版年
2023年 | 39篇 |
2022年 | 120篇 |
2021年 | 158篇 |
2020年 | 103篇 |
2019年 | 145篇 |
2018年 | 175篇 |
2017年 | 106篇 |
2016年 | 119篇 |
2015年 | 101篇 |
2014年 | 140篇 |
2013年 | 177篇 |
2012年 | 220篇 |
2011年 | 213篇 |
2010年 | 127篇 |
2009年 | 84篇 |
2008年 | 130篇 |
2007年 | 111篇 |
2006年 | 101篇 |
2005年 | 125篇 |
2004年 | 77篇 |
2003年 | 57篇 |
2002年 | 57篇 |
2001年 | 16篇 |
2000年 | 33篇 |
1999年 | 30篇 |
1998年 | 24篇 |
1997年 | 20篇 |
1996年 | 16篇 |
1995年 | 12篇 |
1994年 | 7篇 |
1993年 | 12篇 |
1992年 | 13篇 |
1991年 | 20篇 |
1990年 | 16篇 |
1989年 | 14篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 13篇 |
1985年 | 4篇 |
1984年 | 9篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1976年 | 3篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1967年 | 2篇 |
1949年 | 1篇 |
排序方式: 共有3011条查询结果,搜索用时 21 毫秒
91.
Hassen Abu Damir M. Alhaj Ali T. A. Abbas E. A. Omer A. M. Al Fihail 《Comparative clinical pathology》2013,22(3):305-311
Narasin poisoning was reported in 15 camels, 7 adults and 8 young, after accidental access to poultry feed medicated with 60 g narasin per ton. Fourteen camels died between 3 and 20 days, and one young animal survived the dose after developing a chronic course of a disease. The main clinical signs of narasin toxicity in the dromedary include: weakness of hind limbs, lack of coordination, oedema of dependent parts, inappetence, ruminal atony, myoglobinuria, profound depression, tachycardia, sternal recumbency and death. The lesions were mainly in the heart and skeletal muscles and consisted of multifocal degeneration and necrosis of heart and skeletal muscle fibres with areas of regeneration and lung oedema. There was high enzyme activity for creatine kinase (CK), lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase and an increase in urea concentration and white blood cells, neutrophil and platelet counts. Cardiac markers, troponin T, CK-MB and C-reactive protein, showed slight or no changes terminally. 相似文献
92.
93.
94.
Imad Dweikat Enas Naser Nadera Damsah Bassam Abu Libdeh Izzeddin Bakri 《Metabolic brain disease》2012,27(4):613-616
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive disorder caused by mutations in the ETHE1 gene and characterized by chronic diarrhea, encephalopathy, relapsing petechiae and acrocyanosis. Nephrotic syndrome has been described in an infant with EE but the renal histology findings were not described in previous reports. We report a Palestinian girl with EE who presented with chronic diarrhea, encephalopathy, petechial rash and acrocyanosis. Subsequently, she developed progressive deterioration of renal function caused by rapidly progressive glomerulonephritis resulting in death within few days. This is, to our knowledge, the first reported occurrence of rapidly progressive glomerulonephritis in a child with ethylmalonic encephalopathy. Its presence is a serious complication associated with poor prognosis and may be explained by the diffuse vascular damage 相似文献
95.
96.
97.
98.
M. H. M. Mubassir M. Abu Naser Mohd Firdaus Abdul-Wahab Tanvir Jawad Raghib Ishraq Alvy Salehhuddin Hamdan 《RSC advances》2020,10(27):15800
The first layer of defense that plants deploy to ward off a microbial invasion comes in the form of pattern-triggered immunity (PTI), which is initiated when the pattern-recognition receptors (PRRs) bind with the pathogen-associated molecular patterns (PAMPs) and co-receptor proteins, and transmit a defense signal. Although several plant PRRs have been discovered, very few of them have been fully characterized, and their functional parameters assessed. In this study, the 3D-model prediction of an entire plant PRR protein, Xa21, was done by implementing multiple in silico modeling techniques. Subsequently, the PAMP RaxX21-sY (sulphated RaxX21) and leucine-rich repeat (LRR) domain of the co-receptor OsSERK2 were docked with the LRR domain of Xa21. The docked complex of these three proteins formed a heterodimer that closely resembles the other crystallographic PTI complexes available. Molecular dynamics simulations and MM/PBSA calculations were applied for an in-depth analysis of the interactions between Xa21 LRR, RaxX21-sY, and OsSERK2 LRR. Arg230 and Arg185 from Xa21 LRR, Val2 and Lys15 from RaxX21-sY and Lys164 from OsSERK2 LRR were found to be the prominent residues which might contribute significantly in the formation of a heterodimer during the PTI process mediated by Xa21. Additionally, RaxX21-sY interacted much more favorably with Xa21 LRR in the presence of OsSERK2 LRR in the complex, which substantiates the necessity of the co-receptor in Xa21 mediated PTI to recognize the PAMP RaxX21-sY. However, the free energy binding calculation reveals the favorability of a heterodimer formation of PRR Xa21 and co-receptor OsSERK2 without the presence of PAMP RaxX21-sY, which validate the previous lab result.This study exhausts bioinformatics tools to acquire the entire multi-domain rice Xa21 protein structure and analyzes its interactions with its PAMP RaxX21-sY and co-receptor OsSERK2. 相似文献
99.
100.
Favorable outcome to glucocorticoid therapy for engraftment syndrome in pediatric autologous hematopoietic cell transplant
下载免费PDF全文
![点击此处可从《Pediatric transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Chenue Abongwa Rolla Abu‐Arja Stephen Rumelhart Hillard M. Lazarus Ghada Abusin 《Pediatric transplantation》2016,20(2):297-302
ES remains an important cause of morbidity and mortality in children undergoing auto‐HCT. Glucocorticoid use in ES is an area of debate. We retrospectively analyzed single‐institution experience from September 2000 through December 2012 to evaluate the use of glucocorticoids in auto‐HCT patients. ES was defined by the occurrence of new onset of non‐infectious fever plus diarrhea, rash, or pulmonary infiltrates 24‐h before or within five days after neutrophil engraftment. Sixty‐five pediatric patients (<21 yr) with different solid tumors underwent auto‐HCTs in the study period. Fifteen patients (23%) fulfilled criteria for ES, of which 13 received methylprednisolone (2 mg/kg IV for 3–5 days). Clinical improvement occurred in all patients within 48 h without significant complications. In the non‐ES group, 11 patients received glucocorticoid without significant complications as well. MEL‐based regimens were found to be significant factor for ES (p < 0.05). Fever, edema, non‐infectious diarrhea, and serum albumin concentration were statistically different between the two groups. Median hospital length of stay was higher in the ES group. Conclusion: ES is a common complication in children after auto‐HCT and short‐course glucocorticoid therapy is an effective and well‐tolerated treatment, even in those who did not completely fulfill diagnostic criteria. 相似文献