Impact of Frailty on Outcomes After Primary and Revision Total Hip Arthroplasty

Background

Frailty and disability from arthritis are closely intertwined and little is known about the impact of frailty on total hip arthroplasty (THA) outcomes. We hypothesized that higher preoperative frailty is associated with more adverse events following THA.

Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients

Clinical and Experimental Medicine - Identification of host genetic factors influencing the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV)...     

Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers

Journal of Assisted Reproduction and Genetics - Ferroptosis is associated with oxidative stress (OS) and is caused by iron-dependent lipid-peroxidative damage, but its role in PE is unclear. The...     

Intracellular cholestasis: A rare complication of malaria falciparum infection

BackgroundAside from acute viral hepatitides intracellular cholestasis is seen less often with the use of certain drugs, contrast media, leptospirosis and congenital hyperbilirubinaemias. Types of liver injuries complicating malaria usually take the form of acute hepatitis or haemolytic anaemias rather than cholestasis. We report here a rare presentation where a typical intracellular cholestatic picture complicated malaria falciparum in a patient residing in an endemic area.Patient and methodsA 55 year old bank manager presented with malaria fever and deep jaundice for investigations. CBC, LFT, renal function, coagulation profile, liver function test, viral hepatitis markers for HBV and HCV including PCR, U/S liver, MRI liver, CT brain, full septic screen, thin and thick Giemsa-stained blood films and ICT for malaria, leptospira Abs and ANA.ResultsTotal bilirubin 22 mg/dl, conjugated 19 mg/dl, ALT 49, AST 65, alkaline phosphatase 176 (normal), serum albumin 3.5 mg/dl, INR 0.9, urea 98 mg/dl, creatinine 2.3 mg/dl, Hb 8.8, platelet 263, WBC 11000, MCV 84, Coomb’s test negative, haptoglobulin levels: normal, blood culture: negative, HBVDNA and HCVRNA: negative, ANA: negative, blood film and ICT for malaria: positive then turned negative after artemether treatment, leptospira Abs titres for six species including L haeorragiae at days 7, 14 and 60, were: <1/10 negative. Liver U/S normal, MRCP: normal and CT brain: normal patient fully recovered with anti-malarial agent artemether and short course of renal support (haemofiltration).ConclusionIn cases of severe intracellular cholestasis malaria infection should be considered in the differential diagnosis particularly in malaria endemic localities. This rare complication of a common disorder is potentially treatable.     

Interleukin-1 receptor antagonist and interleukin-1β-511 gene polymorphisms among Egyptian children with febrile seizures

Febrile seizures (FSs) are the most common form of childhood seizures. The higher levels of pro-inflammatory cytokines in children may induce seizures, and alternatively, higher levels of anti-inflammatory cytokines may act as a defense mechanism against seizures. We aimed to investigate whether interleukin (IL)-1β-511 C/T (pro-inflammatory cytokine) (rs16944) and IL-1 receptor antagonist (IL-1Ra) (an anti-inflammatory cytokine) gene polymorphisms could be used as markers for prediction of susceptibility to FSs. The current study included 22 patients with FSs and 22 normal control subjects. All patients were subjected to thorough history taking, full neurological examination, electroencephalography, and peripheral blood sampling for genotype analyses. Detection of IL-1Ra gene polymorphisms was done using polymerase chain reaction (PCR), while a restriction fragment length polymorphism analysis of the PCR products was used for the detection of IL-1β-511 C/T gene polymorphisms. The mean age of onset of first febrile seizures was 15.7 months. Eighteen (81.8 %) cases had the criteria of complex FSs. Frequencies of alleles C and T for IL-1β-511 were 26/44 and 18/44, respectively, in FS patients and 22/44 for both in the control subjects. The CC genotype was significantly more common in the FS patients than in the control group. The IL-1Ra-I homozygote was more frequent in patients with FSs than in healthy controls. The IL-1Ra homozygous I/I and IL-1β-511 CC gene polymorphisms are associated with a higher susceptibility to febrile seizures, which may be useful markers for predicting the development of febrile seizures.