全文获取类型
收费全文 | 519篇 |
免费 | 46篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 19篇 |
妇产科学 | 7篇 |
基础医学 | 33篇 |
口腔科学 | 27篇 |
临床医学 | 47篇 |
内科学 | 105篇 |
皮肤病学 | 8篇 |
神经病学 | 20篇 |
特种医学 | 100篇 |
外科学 | 58篇 |
综合类 | 66篇 |
一般理论 | 1篇 |
预防医学 | 34篇 |
眼科学 | 6篇 |
药学 | 18篇 |
中国医学 | 4篇 |
肿瘤学 | 17篇 |
出版年
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 9篇 |
2019年 | 6篇 |
2018年 | 16篇 |
2017年 | 14篇 |
2016年 | 11篇 |
2015年 | 17篇 |
2014年 | 18篇 |
2013年 | 30篇 |
2012年 | 22篇 |
2011年 | 23篇 |
2010年 | 43篇 |
2009年 | 30篇 |
2008年 | 18篇 |
2007年 | 19篇 |
2006年 | 23篇 |
2005年 | 13篇 |
2004年 | 8篇 |
2003年 | 10篇 |
2002年 | 6篇 |
2001年 | 6篇 |
2000年 | 12篇 |
1999年 | 6篇 |
1998年 | 17篇 |
1997年 | 17篇 |
1996年 | 17篇 |
1995年 | 15篇 |
1994年 | 15篇 |
1993年 | 16篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 11篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 8篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1973年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有571条查询结果,搜索用时 15 毫秒
521.
温氧合血连灌与冷晶体液间灌心肌线粒体量化计分及形态改变的对比研究 总被引:6,自引:0,他引:6
目的:对温血连续灌注与冷晶体液间断灌注下心肌线粒体结构及量化计分进行了对比研究。方法:病人分两组(每组7例),主动脉阻断60分钟后及再灌注20分钟各取2mm直径心室壁肌肉置入4℃2.5%戊二醛液中固定2小时。在H600型电镜下选择5个视野、每视野随机观察20个线粒体。依受损程度分为0~4级(0级为正常结构,4级受损程度最重),将100个线粒体按级得分总和除以100即为该组得分数。结果:阻断60分钟线粒体量化计分冷晶组为2.5143±0.2863,温血组计分为1.5486±0.0915(P<0.001)。再灌注20分钟后冷晶组记分为3.0143±0.1792,温血组记分为1.6829±0.1581(P<0.01)。阻断60分钟再灌20分钟电镜下冷晶组线粒体嵴断裂、溶解、基质颗粒丢失明显、内外膜完整性消失;温血组线粒体嵴无断裂、外膜完整、基质颗粒略少。结论:电镜下线粒体超微结构及量化计分证明温血组心肌保护作用明显优于冷晶组。 相似文献
522.
MA Braga O Tarzia CC Bergamaschi FA Santos ED Andrade FC Groppo 《International journal of dental hygiene》2009,7(2):126-130
Abstract: Objective: The aim of the present study was to compare the effect of low‐dose pilocarpine and cevimeline as stimulants for salivary flow in healthy subjects. Methods: In this cross‐over clinical trial with a 1‐week washout period, 40 male volunteers were submitted to an oral dose of pilocarpine 1% (Salagen?) ?60 μg kg?1 body‐weight (Group 1) or Cevimeline (Evoxac?) ?30 mg (Group 2). Saliva samples were collected and the salivary flow rate was measured (ml min?1) at baseline and 20, 40, 60, 80, 140 and 200 min after administration of drugs. In addition, salivary secretion was also measured under mechanical stimulation to observe salivary gland function. Results: The data were analyzed by Friedman and Wilcoxon signed‐rank tests (significance level = 5%). Pilocarpine and cevimeline significantly increased salivary flow 140 min after intake. There was a significant higher secretion with cevimeline 140 and 200 min after administration. There were no differences seen among subjects in the salivary glands function by mechanical stimulation. Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine. 相似文献
523.
524.
Stacy Beck Daniel Wojdyla Lale Say Ana Pilar Betran Mario Merialdi Jennifer Harris Requejo Craig Rubens Ramkumar Menon Paul FA Van Look 《Bulletin of the World Health Organization》2010,88(1):31-38
Objective
To analyse preterm birth rates worldwide to assess the incidence of this public health problem, map the regional distribution of preterm births and gain insight into existing assessment strategies.Methods
Data on preterm birth rates worldwide were extracted during a previous systematic review of published and unpublished data on maternal mortality and morbidity reported between 1997 and 2002. Those data were supplemented through a complementary search covering the period 2003–2007. Region-specific multiple regression models were used to estimate the preterm birth rates for countries with no data.Findings
We estimated that in 2005, 12.9 million births, or 9.6% of all births worldwide, were preterm. Approximately 11 million (85%) of these preterm births were concentrated in Africa and Asia, while about 0.5 million occurred in each of Europe and North America (excluding Mexico) and 0.9 million in Latin America and the Caribbean. The highest rates of preterm birth were in Africa and North America (11.9% and 10.6% of all births, respectively), and the lowest were in Europe (6.2%).Conclusion
Preterm birth is an important perinatal health problem across the globe. Developing countries, especially those in Africa and southern Asia, incur the highest burden in terms of absolute numbers, although a high rate is also observed in North America. A better understanding of the causes of preterm birth and improved estimates of the incidence of preterm birth at the country level are needed to improve access to effective obstetric and neonatal care. 相似文献525.
目的考察多媒体训练软件对聋童言语康复训练的作用。方法根据前测结果将实验对象分为实验组和对照组,实验组使用多媒体训练软件配合教学,对照组采用传统的教学方法。教学结束后,对两组进行相同的测试,对比其发音的准确性。结果实验组成绩显著高于对照组。结论多媒体训练软件有助于提高聋童发音的准确性,多媒体教学方式是聋儿康复教学的有效手段。 相似文献
526.
Fifteen children less than 12 kg in weight underwent transplantation of the liver for biliary atresia; eight survived. Five of the eight survivors had thrombosis of the hepatic artery without portal vein thrombosis. Three of the five patients with hepatic artery thrombosis developed infected bilomas, which were drained percutaneously under ultrasonographic (US) or computed tomographic (CT) guidance. Concurrent therapy with antibiotics and hyperoxygenation resulted in resolution of these intrahepatic collections. Although it had been thought that thrombosis of the hepatic artery most often results in necrosis of the graft and requires retransplantation, the five patients in this study survived without retransplantation. Diagnosis of hepatic artery thrombosis was achieved with the use of Doppler US in four cases, CT in four cases, and angiography in two cases. Duplex Doppler US is the preferred imaging modality. 相似文献
527.
528.
Abantanga FA 《Pediatric surgery international》2005,21(5):400-402
Intussusception is very common in children all over the world, especially those under 2 years. This can be ileoileal, ileocolic, or colocolic, i.e. the immediate proximal part of the intestine telescoping into the distal portion of the intestine. Ileosigmoid intussusception involves the invagination of a loop of the ileum into the sigmoid colon, producing two obstructions: that involving the invaginated loop of terminal ileum and that of the sigmoidorectal intussusception. This can lead to ischaemia and necrosis of either the ileum or sigmoid colon. The case presented here is suspected to be the first one reported in the world scientific literature. 相似文献
529.
In four women pelvic peritoneal inclusion cysts were diagnosed with ultrasound or computed tomography. Three patients had a history of multiple surgical procedures, whereas the fourth had prior severe abdominal trauma. Imaging studies showed large cystic structures contiguous with the adnexa. The normal ovarian appearance was distorted in two women. Pathologic confirmation was obtained in all cases. When large adnexal cystic structures are identified in young women with a history of surgery or trauma, the diagnosis of peritoneal inclusion cysts should be entertained. Recognition should result in conservative therapy rather than salpingo-oophorectomy. 相似文献
530.
MR imaging of laser-tissue interactions 总被引:6,自引:0,他引:6
A new application of magnetic resonance (MR) imaging to map the spatial and temporal distribution of the effects of Nd:YAG lasers on tissues was studied. The temperature dependence of MR relaxation mechanisms and the high sensitivity of MR to changes in the mobility and distribution of tissue water make it particularly suitable for the demonstration and control of thermal energy deposition in tissues. In heterogeneous tissues, MR imaging does not follow changing temperatures directly because even in the case of reversible thermal interactions, there is a hysteresis in the dynamic relationship between MR signal intensity and temperature. Appropriate matching of the laser and MR pulse sequences can, however, optimize the detection of relatively small laser energy deposition, and reversible and irreversible tissue changes can be distinguished. There is a potential for the integration of MR imaging and lasers for three-dimensional control and monitoring of laser-tissue interactions. 相似文献