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31.
ROBERT LEMERY ERIC LAVALLEE ALAIN GIRARD MICHEL MONTPETIT 《Pacing and clinical electrophysiology : PACE》1991,14(7):1158-1168
We evaluated and compared the in vitro characteristics of direct current ablation using high energy ablation (Hewlett-Packard defibrillator) and a new form of low energy ablation (low energy ablation power supply, Cardiac Recorders, UK). Two new catheters with a large distal electrode have been recently introduced for catheter ablation: a low energy 7F bipolar catheter (Bard) with a contoured distal electrode, and a 7F deflectable catheter with a 4-mm tip (Mansfield). In vitro studies were carried out in a large tank filled with physiological saline while recording voltage, current, and pressure. High speed cinematography at 32,000 frames per second (Cordin, Utah) was done to assess the dynamic behavior of the vapor globe with both systems of energy delivery. We evaluated shocks of 50, 100, 150, 200, and 300 joules with the conventional system, and shocks of 10, 15, 20, 30, and 40 joules with the new system, and also compared the effects of varying catheter design with both systems of energy delivery. The conventional system using high energy showed significant arcing and increases in pressure. Low energy direct current ablation produces nonarcing shocks with 20 joules or less, and significantly less vapor globe and gas formation during arcing shocks, with a shorter duration of increase in pressure. This new system using low energy direct current may reduce the risk and complications reported with high energy ablations. 相似文献
32.
Electrode-Heart Interface: Definition of the Ideal Electrode 总被引:1,自引:0,他引:1
Dans la stimulation à deux chambres, pour garder aux stimulateurs leurs avantages de petite taille, de volume réduit et de longue durée, il est nécessaire de diminuer les seuils de stimulation. Ceci peut être accompli par ľoptimisation de ľinterface électrode-coeur. Des nouvelles électrodes pourraient réquire les pertes de polarisation; de même, des nouveaux matériaux pourraient être envisagés. Les résultats de ces données doivent être rapportés à stimulation chronique.
In dual-chamber pacing in order to maintain the advantages of small pulse generator size and volume, and increased longevity, it becomes necessary to reduce pulse generator output. This may be accomplished by optimizing the electrode-heart interface. New electrode designs may reduce polarization losses; perhaps even newer materials should be considered. The results of accumulated data must be applicable to long-term pacing. 相似文献
In dual-chamber pacing in order to maintain the advantages of small pulse generator size and volume, and increased longevity, it becomes necessary to reduce pulse generator output. This may be accomplished by optimizing the electrode-heart interface. New electrode designs may reduce polarization losses; perhaps even newer materials should be considered. The results of accumulated data must be applicable to long-term pacing. 相似文献
33.
STÉPHANE BOULÉ M.D. FRANÇOIS BRIGADEAU M.D. CHRISTELLE MARQUIÉ M.D. JULIA SALLERON M.D. DIDIER KLUG M.D. Ph.D. CLAUDE KOUAKAM M.D. LAURENCE GUÉDON‐MOREAU M.D. ALAIN DUHAMEL M.D. Ph.D. CHARLES ACHERÉ M.D. LUDIVINE WISSOCQUE M.D. DOMINIQUE LACROIX M.D. Ph.D. SALEM KACET M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2012,35(10):1209-1216
Background: Little is known about predictors of antitachycardia pacing (ATP) failure in implantable cardioverter defibrillator (ICD) recipients. Distance between the stimulation site and the ventricular tachycardia (VT) site of origin may critically affect ATP effectiveness. We hypothesized that ATP may be less effective in ICD patients who had basal VT than in those who had apical VT. Methods: We reviewed data from 52 patients with sustained monomorphic VT and left ventricular disease referred for ICD implantation. ATP was delivered exclusively at the right ventricular apex. The clinical VTs site of origin (basal, midventricular, or apical) was determined in each patient, using 12‐lead electrocardiogram. VTs episodes treated with ATP during the 1‐year follow‐up were studied. ATP success rate (%), defined as the ratio between the number of successful ATP sequences and the number of delivered ATP sequences, was determined in each patient. Results: VT exit site was apical in 19 patients (36%), basal in 18 patients (35%), and midventricular in 15 patients (29%). In those 52 patients, 1,393 ATP sequences, delivered to treat 761 VT episodes, were analyzed. ATP success rate was found to be associated with the VT site of origin (median [interquartile range]): basal (33%[11–67]), midventricular (50%[37–100]), apical (100%[41–100]) (P = 0.027). Multivariate analysis identified basal VT site of origin as an independent predictor of ATP failure (P = 0.023). Conclusion: ATP is less effective in ICD patients who had basal VT than in those who had apical VT before ICD implantation. (PACE 2012; 35:1209–1216) 相似文献
34.
MIGUEL SOUSA UVA M.D. VICTOR A. JEBARA M.D. JEAN NOEL FABIANI M.D. SIMONE MASSONET CASTEL M.D. CHRISTOPHE ACAR M.D. PHILIPPE GRARE M.D. JEAN C. DIB M.D. ALAIN DELOCHE M.D. ALAIN CARPENTIER M.D. PH.D. 《Journal of cardiac surgery》1992,7(3):240-244
Ten patients with human immunodeficiency virus (HIV) infections underwent cardiac surgery using cardiopulmonary bypass. All were in Centers for Disease Control (CDC) group II. The cardiac involvement was either urgent or severely symptomatic in all cases. One patient died due to acquired immunodeficiency syndrome (AIDS) unrelated cause. No complications were encountered in this series. Eight of the nine survivors were available for follow-up. Three of these eight patients progressed to AIDS (CDC group IV) and subsequently died. Five patients are alive and in CDC group II. Prognosis of the HIV infection and the natural history of the cardiac disease are the two main elements to be considered whenever cardiac surgery is required. 相似文献
35.
ARTHUR M. FELIX EDGAR P. HEIMER CHING-TSO WANG THEODORE J. LAMBROS ALAIN FOURNIER THOMAS F. MOWLES SARAH MAINES ROBERT M. CAMPBELL BOGDA B. WEGRZYNSKI VOLDEMAR TOOME DAVID FRY VINCENT S. MADISON 《Chemical biology & drug design》1988,32(6):441-454
A novel cyclic GRF analog, cyclo(Asp8-Lys12)-[Asp8,Ala15]-GRF(1-29)-NH2, i.e. cyclo8.12[Asp8,Ala15]-GRF(1-29)-NH2, was synthesized by the solid phase procedure and found to retain significant biological activity. Solid phase cyclization of Asp8 to Lys12 proceeded rapidly (~2h) using the BOP reagent. Substitution of Ala12 with d -Ala2 and/or NH2-terminal replacement (desNH2-Tyr1 or N-MeTyr1) in the cyclo8.12[Asp8,Ala15]-GRF(1-29)-NH2 system resulted in highly potent analogs that were also active in vivo. Conformational analysis (circular dichroism and molecular dynamics calculations based on NOE-derived distance constraints) demonstrated that cyclo8.12[Asp8,Ala15]-GRF(1-29)-NH2 contains a long α-helical segment even in aqueous solution. A series of cyclo8.12 stereoisomers containing d -Asp8 and/or d -Lys12 were prepared and also found to be highly potent and to retain significant α-helical conformation. The high biological activity of cyclo8.12[N-MeTyr1,d -Ala2,Asp8,Ala15]-GRF(1-29)-NH2 may be explained on the basis of retention of a preferred bioactive conformation. 相似文献
36.
Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in athletes. Blood sampling and doping control 总被引:3,自引:0,他引:3
AGNES SOUILLARD MICHEL AUDRAN FRANÇOISE BRESSOLLE RAYNALD GAREAU ALAIN DUVALLET & JEAN-LOUIS CHANAL 《British journal of clinical pharmacology》1996,42(3):355-364
1 The pharmacokinetics of recombinant human erythropoietin (rHuEpo) were initially determined in two healthy volunteers after a single subcutaneous dose (50 u kg−1 ). Twenty subjects then received repeated subcutaneous administrations of high dose (200 u kg−1 ) rHuEpo and 10 subjects received placebo. An immunoradiometric assay was used to measure the concentrations of erythropoietin (Epo) in serum and urine.
2 Serum Epo concentration-time profiles were best described by a one-compartment open model with zero-order input. The mean elimination half-life (±s.d.) was 42.0±34.2 h. Clearance, uncorrected for bioavailability, was 0.05±0.01 l h−1 kg& minus;1 . Erythropoietin concentrations returned to normal values in serum and urine, 7 and 4 days after the last administration, respectively.
3 The recombinant hormone was well tolerated. Significant changes in reticulocytes and red blood cells, haemoglobin concentrations and haematocrit were observed after administration of rHuEpo. In the control group, these parameters remained unchanged.
4 The change in reticulocytes was used as an index of the therapeutic effect of rHuEpo. The concentration-effect relationship was best described by an exponential model.
5 These data show the limitations of the measurement of Epo concentrations in blood and urine samples, collected in athletes during competition, for antidoping control. Epo doping can be detected only during or within 4 to 7 days of ending, a course of rHuEpo. 相似文献
2 Serum Epo concentration-time profiles were best described by a one-compartment open model with zero-order input. The mean elimination half-life (±s.d.) was 42.0±34.2 h. Clearance, uncorrected for bioavailability, was 0.05±0.01 l h
3 The recombinant hormone was well tolerated. Significant changes in reticulocytes and red blood cells, haemoglobin concentrations and haematocrit were observed after administration of rHuEpo. In the control group, these parameters remained unchanged.
4 The change in reticulocytes was used as an index of the therapeutic effect of rHuEpo. The concentration-effect relationship was best described by an exponential model.
5 These data show the limitations of the measurement of Epo concentrations in blood and urine samples, collected in athletes during competition, for antidoping control. Epo doping can be detected only during or within 4 to 7 days of ending, a course of rHuEpo. 相似文献
37.
RENE SEYER ANDRE AUMELAS ALAIN CARATY PIERRE RIVAILLE BERTRAND CASTRO 《Chemical biology & drug design》1990,35(5):465-472
The coupling reagent (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium (BOP) hexafluorophosphate was tested in the synthesis of luliberin (LH-RH) with inexpensive classically protected Boc-amino acids, in slight excess, and benzhydryl amino resin, without any other additive. The good solubility of this reagent and its by-products is of particular interest for automated peptide synthesis. [D-H-S1]LH-RH was also synthesized and compared with LH-RH by proton nuclear magnetic resonance spectroscopy. As shown by the biological tests and the high performance liquid chromatography study, unprotected pyroClu and Boc-His can be used without any significant racemization but Boc-His(Boc) was found to be preferable since it gave no detectable racemization and no by-products. The difficult isolation of the minority D-derivative from the crude preparation of LH-RH was resolved by a recycling procedure in reversed phase HPLC. 相似文献
38.
ALAIN M. LAVOIPIERRE JOHN J. HATFIELD 《Journal of Medical Imaging and Radiation Oncology》1985,29(4):332-334
Haemoptysis can be difficult to diagnose. A case is reported where haemoptysis resulting from a false mycotic aneurysm consequent upon a lung abscess was diagnosed prior to surgery by C.T. scanning. The place of C.T. scanning in the diagnosis of paramediastinal masses is briefly reviewed and the need for bolus injection of contrast medium during dynamic C.T. scanning is stressed. 相似文献
39.
Early released lipid-soluble cardiodepressant factor and elevated oestrogenic substances in human septic shock 总被引:1,自引:0,他引:1
CLAUDINE BENASSAYAG NÉVÉNA CHRISTEFF MARIE-CLAUDE AUCLAIR CATHERINE VERNIMMEN CLAIRE CARLI-VIELLE† EMMANUEL NUNEZ ALAIN CARLI‡ 《European journal of clinical investigation》1984,14(4):288-294
A cardiodepressant factor (CDF) able to decrease contractile activity of cultured rat heart cells was determined to be located in the lipid-soluble fraction of sera from men in septic shock. This heat-stable CDF has a molecular weight under 1000. Repeated fractionations of sera gave evidence of an oestrone-like chromatographic behaviour. Oestrone, oestradiol and cortisol were immunologically quantified in two groups (recovery and death) of men in septic shock. All of them were elevated in sera from patients with shock. Highest levels of oestrone 4330 pmol 1(-1), (SEM +/- 851, n = 15), oestradiol 1030 pmol 1(-1), (SEM +/- 220, n = 15) and cortisol 1096 pmol 1(-1), (SEM +/- 94, n = 15), were found in patients who failed to recover from shock. However, oestrone levels were the most striking, especially in the male. This study gives evidence for a polarity relationship between the CDF and oestrone, but natural oestrone does not appear to be a direct CDF. Moreover, this study shows that radioimmunoassay of oestrone could be an important index evaluating the severeness of septic shock. 相似文献
40.
ALAIN J. DUCLOS ELIAS K. HADDAD MALCOLM G. BAINES 《American journal of reproductive immunology (New York, N.Y. : 1989)》1995,33(5):354-366
PROBLEM : Even though our knowledge of the phenomenon at play at the fetoplacental interface has greatly advanced during the past years, a complete understanding of the reasons why the developing embryo is not rejected by maternal immune effector cells remains largely unknown. METHODS : We have used immunohistochemistry with the macrophage-specific markers F4/80 and MHC II to study the relationship between decidual infiltration and resorption in murine models of embryo loss between days 6 and 10 of gestation. RESULTS : Analysis of day 8 CBA/J × DBA/2 pregnancies has revealed 2 distinct populations of embryos. The majority (69.4%) expressed low levels of F4/80+ cells, but a minority (30.6%) expressed much higher level of the macrophage marker. In CBA/J × BALB/c, most embryos (91.7%) expressed low numbers of F4/80+ cells. As earlier experiments established that products of activated macrophages (TNF-α and nitric oxide) were implicated in embryo loss in this model, the activation status of the F4/80+ macrophages was assessed through the cell surface expression of MHC II. Again, a similar association was established: 30.6% of the CBA/J × DBA/2 embryos were infiltrated by significantly more MHC II+ cells than the control CBA/J × BALB/c mating. Finally, when coordinate expression of F4/80, MHC II and CD11b was assessed, it was found that an embryo significantly infiltrated by cells bearing one of the 3 markers was also heavily infiltrated by cells bearing the 2 other markers. CONCLUSIONS : This study has shown that the augmented infiltration of the deciduum with maternal macrophages is an early event which precedes spontaneous abortion of the early embryo. 相似文献