Influence of Preparation Factors on the Sustained Release of Nifedipine from Eudragit RL/RS Microspheres

用乳剂—溶剂挥发法制备硝苯地平的丙烯酸树脂缓释微球。微球中药物的释放速度随丙烯酸树脂ＥｕｄｒａｇｉｔＲＬ／ＲＳ比率的增加以及制备时搅拌速率的增加而增大，随内相聚合物浓度的增加及微球粒径的增加而减小，释药５０％所需时间与微球粒径呈良好线性。微球的释药速率也随药物含量的增加（从４．２％到１６．７％）而增大，并快于药物结晶的溶解速率，但药物含量达２６．６％时，微球释药速率明显下降并低于药物结晶的溶解速率。用差热分析和Ｘ射线衍射分析证明，药物含量为４．２，９．４和１６．７％的微球中药物完全是以非晶态分散的，而含药２６．６％的微球中有药物结晶存在。不同微球释药低于７０％时，释放方式均符合Ｈｉｇｕｃｈｉ时间平方根方程。     

In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3 gene co-transfected leukemia cells

In vitro proliferation and in vivo tumorigenicity of IL-2 and/or IL-3 gene transfected FBL-3erythroleukemia cells were observed to investigate the anti-tumor effect of tumor vaccine. Methods: Leukemiacells were trans fected with IL-2 and/or IL-3 adenovlrus vector. The cytokine expressions were assayed, and the growth characteristics of the transfected FBL-3 cells were studied. Results: High levels of secreted IL-2 and IL-3remained for one week after transfection, and the trans fected leukemia cells became unchanged in growth in vitro and showed weak tumorigenicity in vlvo. The tumorigenicity of FBL-3 cells decreased more significantly when FBL-3 cells were transfected with both IL-2 gene and IL-3 gene than when FBL-3 cells were tran fected with IL-2or IL-3 gene only. The tumor growth was significantly delayed and survival time of the trans fected FBL-3 inoculat ed mice was significantly prolonged. Conclusion: The inhibition of tumor growth is most likely dependent on immune response induced by IL-2     

颌面部的十大间隙制作法

颌面部的十大间隙制作法方实邦（南京医科大学解剖学教研室，南京２１００２９）魏保庆（江苏职工医科大学解剖学教研室，南京２１００２９）关键词解剖学；标本制作；颌面部；间隙制作法颌面十大间隙的标本制作对于口腔专业解剖学十分重要，它可使学生对照理论难以理解的...     

四肢关节部位创面的修复

四肢关节部位创面的修复王剑利魏海温张成进王成琪１９７８年～１９９１年，共收治四肢各关节部位创面２１６例。急诊６９例，均在１２ｈ以上，创面污染严重；慢性感染创面１４７例，其中病程在１个月以内６４例，３个月以内４１例，６个以内２８例，１年以内１２...     

亚硒酸钠对HL—60细胞的分化诱导作用

目的观察亚硒酸钠对人急性髓系白血病ＨＬ－６０细胞系的诱导分化作用。方法ＨＬ－６０细胞在含８×１０－６ｍｏｌ／Ｌ亚硒酸钠的ＲＰＭＩ１６４０培养液中置３７℃、５％ＣＯ２、９５％空气、饱和湿度培养５天，于第５天查细胞形态学及硝基四氮唑蓝（ＮＢＴ）试验。结果硒在上述条件下可使ＨＬ－６０细胞形态学分类中较成熟细胞的比例增高（Ｐ＜０．０５），ＮＢＴ试验阳性率增高（Ｐ＜０．０１）。结论硒在一定条件下可能有潜在的诱导分化作用     

肾脏恶性肿瘤的根治性治疗

肾脏恶性肿瘤的根治性治疗大连铁路医院（１１６００１）孟庆国，魏熹元自１９８８年１０月至１９９４年１２月，我院采用经腹扩大根治术加系统性化疗治疗肾脏恶性肿瘤２４例，效果良好．现报告如下．临床资料１．一般资料２４例中，男１８例、女６例，年龄６～７２岁，平...     

儿童发育期含牙囊肿30例临床分析

含牙囊肿是牙源性囊肿中较多见的一种，发生于牙冠形成之后，在缩余釉上皮与牙冠面之间出现渗出液的聚积，而形成的一种囊肿，由于囊内有正在发育的恒牙胚，我们称它为发育期含牙囊肿，是儿童口腔科常见的疾病之一。含牙囊肿发病进程缓慢，早期不易被发现，临床中多因囊肿...     

用血浆分离法治疗蛇毒中毒一例

用血浆分离法治疗蛇毒中毒一例姜埃利魏世津张璐仁齐卫徐莹患者男，３２岁。因五步毒蛇咬伤右手无名指４４小时后，全身无力，来我院就医。查体：体温３６．７℃，呼吸２０次／分，脉搏８０次／分，血压１６／１２ｋＰａ（１２０／９０ｍｍＨｇ），体重为５０ｋｇ。眼睑无...