成人股骨头缺血性坏死的CT诊断分析

成人股骨头缺血性坏死（avascular necrosis of femoral head,ANFH）是由法国人Welfling 1951年首先提出。早期发现病变并了解其进展,及早进行有效地干预尤为重要。本文选取我院2003年至2008年行CT检查诊断的65例ANFH患者的临床资料进行回顾性分析,现报道如下。     

Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer

Objective:To investigate the anticancer effects of warming and relieving cold phlegm formula(温化寒痰复方,WRCP),a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis,Phytolacca acinosa,Panax notoginseng,and Gekko swinhonis G u enther,combined with 5-fluorouracil(5-FU)on human breast cancer in vivo.Methods:Seventy-two Nu/Nu mice inoculated with MDA- MB-231 breast cancer cells were randomized into the control group,5-FU group,high-dose WRCP(hWRCP)group, medium-dose WRCP(mWRCP)group,low-dose WRCP(IWRCP)group,or combination of mWRCP and 5-FU group in a 1:1:1:1:1:1 ratio.Drug administration was commenced on the day following tumor implantation.The control group was injected daily with normal saline(N.S.)intraperitoneally;the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments;the hWRCP group,mWRCP group and IWRCP group received daily doses of 5,1,and 0.2 g/kg of WRCP,respectively,by gastric perfusion;and the combination group was treated with 5-FU plus mWRCP on the same schedules as above.All treatments lasted for 22 days.Tumor volume,tumor weight,inhibition rate of tumor weight,necrosis rate of tumor,organ index,and change in body weight of nude mice were measured.Results:The combination group and the hWRCP group had significantly smaller tumor volumes(580±339 mm~3 and 587±249 mm~3 versus 1055±234 mm~3,respectively), lower tumor weights(0.42±0.29 g and 0.52±0.29 g versus 0.80±0.15g,respectively),and higher tumor necrosis rates(22.7%and 25.6%versus 9.4%,respectively)as compared with the control group(all P<0.05).Similar changes were found in the 5-FU,mWRCP,and IWRCP groups when compared with the control group but were not statistically significant,except for the tumor weight for the 5-FU group.The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group(778±202 mm~3,bothP<0.05).The combination group had the highest tumor inhibition rate(47.7%),followed by the hWRCP group(35.2%)and 5-FU group(28.3%).The 5-FU group had a lower body weight increase(1.37±2.06 g versus 5.60±0.72g,P<0.05) and a lower spleen index(4.064±1.774 mg/10g versus 5.294±1.796 mg/10g)as compared with the control group,whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52±1.80 g(P<0.05)and spleen index of 7.036±1.599 mg/10 g(P<0.05).The spleen indices in the hWRCP, mWRCP,and IWRCP group were all significantly higher than that in the 5-FU group(P<0.01 or P<0.05).No significant differences in body weight change were observed in WRCP groups compared with the control group (P>0.05).Conclusion:The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants.     

彩色多普勒超声诊断胎儿脐绕颈的价值研究

目的探究彩色多普勒在产前超声诊断胎儿脐绕颈（UCAN）中的临床应用价值。方法回顾性分析106例超声诊断脐绕颈的声像图资料观察其诊断符合率,并与无胎儿脐带绕颈的正常组进行对比分析。结果产前超声诊断106例,产后分娩和手术证实与临床符合率达93．4％（99／106）,误诊率为6．6％（7／106）。结论彩色多普勒超声对诊断胎儿脐带绕颈有较高的价值,能够为临床提供客观的影像学诊断依据,对选择分娩方式具有重要意义。     

镉对豚鼠心脏的毒性影响

不同浓度的CdCl_2可使豚鼠右心室乳头肌毒性表现不同。2×10~(-5)M对豚鼠快反应APA及Vmax无显著影响。10~(-4)和5×10~(-4)M可抑制APA、Vmax,缩短APD抑制FC。而在慢反应实验中均呈抑制作用。实验说明低剂量cd使心肌细胞兴奋收缩脱耦联,大剂量对心肌有直接的毒性作用。     

STK15 mRNA在胃癌组织中表达的实验研究

目的 探讨丝氨酸/苏氨酸激酶15(STK15)mRNA在胃癌组织中的表达情况.方法:采实时荧光定量PCR法分别对70例胃癌组织、35例胃癌旁正常组织、30例不典型增生胃组织中的STK15的mRNA表达进行检测.并探讨STK15 mRNA水平和胃癌临床病理特征间的关系.结果:胃癌组织中STK15 mRNA表达明显高于胃癌旁正常组织、不典型胃增生组织(P<0.05);胃癌旁正常组织与不典型胃增生组织比较,STK15mRNA表达差异不显著(P>0.05);STK15 mRNA胃癌中表达在浸润程度T3~T4、TNM分期Ⅲ~Ⅳ期患者中表达较高,与T1~T2、Ⅰ~Ⅱ期患者比较差异有统计学意义(P<0.05);STK15 mRNA胃癌中表达在性别、年龄、分化程度、肿瘤大小组内比较差异无统计学意义(P>0.05).结论:STK15 mRNA在胃癌组织中表达较高,可以成为胃癌细胞特异性指标;STK15 mRNA高表达与胃癌恶性程度及进展有关.