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目的:比较尼莫地平固体分散片(尼达尔)与进口尼莫地平片(Nimotop)和国产片的溶出度和生物利用度。方法:在4种溶剂系统中比较尼达尔和进口及国产片的溶出度;用HPLC测定8名健康受试者交叉一次po尼达尔和Nimotop的生物利用度。结果:尼达尔的溶出性能与Nimotop相似,溶出百分率接近,明显高于国产片;以体积分数为14.25%的乙醇溶液为溶剂,尼达尔45min的溶出度可达80%以上;尼莫地平在人体的血药浓度可用一室开放式模型拟合,尼达尔的相对生物利用度为进口片Nimotop的96.32%,两者的药动学参数相似。结论:尼达尔明显优于其它国产片,而与进口片生物等效。 相似文献
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Primary studies on heroin abuse and injury induced by oxidation and lipoperoxidation 总被引:17,自引:1,他引:17
Objective To further reveal serious risks of heroin abuse to human body and clarify grave injuries of oxidation, peroxidation and lipoperoxidation induced by nitric oxide and other free radicals to heroin abusers.Methods Determined and compared plasma levels of nitric oxide (P-NO), vitamin C (P-VC) , vitamin E (P-VE), β-carotene (P-β-CAR), lipoperoxides (P-LPO) a nd eryt hrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathi one peroxidase (E-GSH-Px) and erythrocyte level of lipoperoxides (E-LPO) in 1 37 cases of heroin abusers (HAs) and 100 cases of healthy volunteers (HVs), used linear regression and correlation, stepwise regression and correlation to analy ze correlation among heroin-abusing-duration (HAD), daily-heroin-abusing-qu antity (DHAQ) with above determination values in the HAs. Results Compared with the above average values in the HVs group, the average values of P -NO, P-LPO, E-LPO in the HAs group were significantly increased (P<0 .000 1), the average values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GS H-P x were significantly decreased (P<0.0001); the analysis of linear regressio n and correlation showed that with ascending of the HAD and DHAQ in the HAs, the values of P-NO, P-LPO, E-LPO were gradually increased (P<0.0001), t he values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, E-GSH-Px were gradu ally dec reased (P<0.0001); the analysis of stepwise regression and correlation sugg ested that the correlation among the HAD, DHAQ with the values of P-NO, P-VC, P-VE was the closest.Conclusion The balance between oxidation and antioxidation in the HAs was seriously destroy ed, and the injuries induced by nitric oxide and other free radicals, oxidation, peroxidation and lipoperoxidation reactions to the body of HAs gravely exacerba ted. In the abstaining from heroin dependence, therefore, it should consider th at sufficient quantum antioxidants such as VC, VE and β-CAR are dosed to the H As so as to abate the injuries to their bodies. 相似文献
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改良技术虫草头孢菌粉提取物对缺血性心律失常和心肌细胞动作电位的影响 总被引:1,自引:0,他引:1
目的 观察采用改良技术获得的虫草头孢菌粉(Cordyceps Cephalosporium Mycelia,CCM)提取物对豚鼠乳头肌动作电位的影响,探讨CCM提取物实验性抗室性心律失常的机制。 方法 利用垂体后叶素(Pit)诱发的大鼠缺血性心律失常模型,观察用药前后心电图的改变。采用标准玻璃微电极技术,记录豚鼠乳头肌跨膜动作电位(TAP)。在频率为1.0 Hz刺激下,观察不同浓度的CCM提取物(10,30,100 mg·L-1)对标准Tyrode液灌流心肌TAP的影响。 结果 大鼠在尾静脉注射Pit后,其心电图T波波幅发生双向性改变,CCM提取物可明显减弱Pit对T波的影响,并降低Pit诱导的心律失常发生率。不同浓度的CCM提取物可浓度依赖性地降低动作电位幅度(APA)以及0相最大上升速率(Vmax);可延长动作电位复极50%和90%的时间(APD50、APD90);但对静息电位(RP)无明显影响。 结论 改良技术获得的CCM对APA和Vmax的抑制及对心室肌APD的延长可能是其抗心律失常作用的电生理基础。 相似文献
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用RP-HPLC法测定曲尼司特血药浓度,对12名健康志愿者口服曲尼司特200和400mg(每个剂量组6人)的药代动力学进行了研究.结果表明,志愿者口服曲尼司特,药-时曲线符合一级吸收-房室模型,各药代动力学参数在二个剂量组无显著性差异,但Cmax和AUC与剂量成比例,提示该药在400mg剂量以下时在人体内呈线性消除动力学. 相似文献
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地佐辛、酮咯酸氨丁三醇、盐酸托烷司琼与0.9%氯化钠注射液配伍在硅橡胶材料镇痛泵储药囊中的稳定性研究 总被引:1,自引:1,他引:0
目的 研究地佐辛、酮咯酸氨丁三醇、盐酸托烷司琼3种注射液和0.9%氯化钠配伍在硅橡胶材料镇痛泵储药囊中的稳定性。方法 应用pH计、微粒分析仪、高效液相色谱仪分别测定4,25,35 ℃下硅橡胶储药囊中配伍溶液在72 h内pH值、不溶性微粒数和各成分含量的变化。结果 4,25,35 ℃下硅橡胶储药囊中配伍溶液的外观和pH值在72 h内均未见明显变化,不溶性微粒符合药典要求;地佐辛、酮咯酸氨丁三醇与托烷司琼的相对含量均在96%~102%。结论 地佐辛、酮咯酸氨丁三醇、托烷司琼注射液与0.9%氯化钠配伍在硅橡胶材料镇痛泵储药囊中72 h内稳定。 相似文献
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建立院内药物警戒制度的实践 总被引:1,自引:0,他引:1
药物警戒(pharmacovigilance)是发现、评估、理解和预防药物不良作用或任何其他药物相关问题的科学和活动~([1-2]).药物警成的概念较传统的药品不良反应监测更广泛,因为它还关注不合理用药和药品质量等问题~([3-4]).其最终目的是综合评价药物的风险效益,提高临床合理用药水平和保障公众用药安全.有资料表明,大量严重的不良反应事件发生在医院中,记录和预防医院中的不良反应事件非常重要,国外药剂师在这方面发挥了重要作用~([5]).国内不少医院及时转载了国家食品药品监督管理局发布的各期<药物警戒快讯>和<药品不良反应信息通报>,给临床提供了大量有价值的信息,但医院内部开展药物警戒目前还少有文献报道. 相似文献