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991.
粒细胞集落刺激因子(granulocyte colonysti mulating factor,G-CSF)主要用于各种粒细胞减少症的治疗,如放疗、化疗引起的粒细胞减少、再生障碍性贫血等,还用于干细胞移植、抗感染等治疗。 相似文献
992.
993.
一日,我带儿子在院子里和其他小朋友玩耍.小朋友里有一个叫贝贝的小女孩儿.长得乖巧可爱,一双黑黝黝的大眼睛闪着顽皮的光芒.她有两岁零四个月了.正让她爸爸带着玩跷跷板呢! 相似文献
994.
995.
目的总结了对一些反复发作的自发性气胸患者采用胸腔持续负压吸引加高渗葡萄糖灌注的方法进行治疗的体会。方法对42例反复发作两次以上的自发性气胸患者先给予胸腔引流管持续负压吸引,然后向胸腔内灌注50%葡萄糖注射液50mL一至三次。结果17例患者在灌注后第二天胸腔引流管中已无气体引出,15例在灌注后第三天漏气停止;8例患者虽仍有气体引出,但气体量明显减少,再次行胸腔灌注后漏气停止;3例患者先后进行灌注三次而痊愈。结论用胸腔持续负压吸引加高渗葡萄糖灌注来治疗进行非手术胸膜固定,是一种风险较小、简便易行、疗效满意的方法,尤其是在技术条件和设备条件差的基层医院,更值得推广。 相似文献
996.
Objective: Support Vector Machine (SVM) is a machine-learning method, based on the principle of structural risk minimization, which performs well when applied to data outside the training set. In this paper, SVM was applied to predict 5-year survival status of patients with nasopharyngeal carcinoma (NPC) after treatment, we expect to find a new way for prognosis studies in cancer so as to assist right clinical decision for individual patient. Methods: Two modelling methods were used in the study; SVM network and a standard parametric logistic regression were used to model 5-year survival status. And the two methods were compared on a prospective set of patients not used in model construction via receiver operating characteristic (ROC) curve analysis. Results: The SVM1, trained with the 25 original input variables without screening, yielded a ROC area of 0.868, at sensitivity to mortality of 79.2% and the specificity of 94.5%. Similarly, the SVM2, trained with 9 input variables which were obtained by optimal input variable selection from the 25 original variables by logistic regression screening, yielded a ROC area of 0.874, at a sensitivity to mortality of 79.2% and the specificity of 95.6%, while the logistic regression yielded a ROC area of 0.751 at a sensitivity to mortality of 66.7% and gave a specificity of 83.5%. Conclusion: SVM found a strong pattern in the database predictive of 5-year survival status. The logistic regression produces somewhat similar, but better, results. These results show that the SVM models have the potential to predict individual patient's 5-year survival status after treatment, and to assist the clinicians for making a good clinical decision. 相似文献
997.
目的克隆人的OVCA1基因并探讨其对卵巢癌细胞生长的影响。方法从健康人卵巢组织中提取总RNA,采用逆转录酶-聚合酶链反应(RT-PCR)方法扩增OVCA1基因并克隆。脂质体法将含有OVCA1质粒和空载体分别转染入A2780细胞,G418筛选稳定转染细胞。MTT法检测OVCA1对A2780细胞生长的影响。结果测序证实获得了OVCA1基因;过表达OVCA1的细胞与对照组相比,生长速度明显减慢(P<0.05)。结论得到了OVCA1基因克隆;OVCA1在体外明显抑制卵巢癌细胞系A2780的生长。 相似文献
998.
999.
阿魏酸对骨髓基质干细胞的成骨分化与增殖的影响实验研究 总被引:1,自引:0,他引:1
目的探讨阿魏酸对骨髓基质干细胞的成骨分化与增殖的影响。方法通过大鼠骨髓基质干细胞(BM—SCs)的成骨诱导与培养进行分组实验,实验分4组:A组(对照组);B组(成骨诱导组);C组(阿魏酸组);D组(联合培养组,阿魏酸联合成骨诱导剂),观察对比分析各组细胞特征、细胞计数、BMSCs的碱性磷酸酶(ALP)活性和细胞内骨钙素含量测定。结果D组ALP活性最强和细胞内骨钙素含量测定最高,与A组、B组和c组对比,差异均有统计学意义(P〈0.05)。结论阿魏酸联合成骨诱导剂可以有效的促进骨髓基质干细胞的成骨分化与增殖的功能,需要进一步研究阿魏酸的临床应用。 相似文献
1000.
Objective To investigate prognostic factors of immunosuppressive therapy (IST) in children acquired severe aplastic anemia(SAA). Methods Data of 56 consecutive children cases with SAA who had received rabbit anti-thymocyte globulin (R-ATG) [3-5 mg/(kg·d)×5 d] and cyclosporine A (CSA) from January 2000 to June 2006 were retrospectively analyzed. No repeated courses of R-ATG were given for nortresponders. All the patients also received stanozolol or testosterone propionate. The dose of CSA was adjusted to maintain trough drug levels above 100 μg/L and peak drug levels above 300 μg/L. Results The overall response rate to the immtmosuppressive therapy (IST) was 62.5% and the complete remission rate was 37.5%. The 5-year overall survival for IST regimens was 66.27%±6.84%, patients who had infections when using ATG had significandy lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥ 10% had good prognosis. Patients whose granulocytes population in bone marrow was ≥10% had lower mortality. Conclusion Patients who had infections when using ATG had significantly lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥10% had good prognosis. 相似文献