排序方式: 共有85条查询结果,搜索用时 552 毫秒
41.
Objective To study the clinicopathologic features,immunophenotype,differential diagnosis and prognosis of uterine epithelioid trophoblastic tumor(ETT).Methods From 2000 to 2007,5 ETTs cases were diagnosed in the affiliated Women's Hospital,School of Medicine,Zhejiang University.The pathologic characteristics and immunophenotype of the tumors were analyzed by histological examination and immunohistochemistry of CK18,p63,inhibin-α,HCG,HPL,PLAP and Ki-67.The clinical prognostic factors were evaluated based on a following-up data with a period of 11-SO months.Results The overall prevalence of ETT was 0.48% among all the gestational trophoblastic diseases patients received in the same period.Five ETT patients were in the reproductive ages with a median of 33 years.Histologically,the tumor showed an invasive,nodular growth consisting of uniform mononuclear trophoblastic cells.There were zones of hyaline material in the tumour nests.Necrosis was commonly seen with a characteristic geographic pattern.Immunohistochemically,all cases displayed a diffuse CK18 and p63 positivity,to be either positive focally or negative for HCG,HPL and PLAP staining.Inhibin-a staining was positive or negative either in the 5 cases.Two patients died of the tumour relapse:one died after 1 year with the tumor having a high mitotic activity(averagely 15 mitotic figures per 10 high-power fields),and the other died of lung metastasis 2 years after the diagnosis.Conclusions ETT is a rare trophoblastic disease with distinct clinicopathological features and immunostaining patterns.A high mitotic index and lung metastasis are indicators for an unfavorable prognosis. 相似文献
42.
43.
44.
脆性组胺酸三聚体蛋白在上皮性卵巢肿瘤中的表达 总被引:2,自引:0,他引:2
目的 :探讨脆性组胺酸三聚体 (FHIT)蛋白在上皮性卵巢肿瘤组织中的表达及其意义 ,分析FHIT与P5 3蛋白、nm2 3 H1产物表达之间的相关性。方法 :应用免疫组化二步法检测 83例上皮性卵巢肿瘤蜡块组织标本中FHIT蛋白、P5 3蛋白及nm2 3 H1产物的表达。结果 :FHIT蛋白缺失仅见于恶性上皮性卵巢肿瘤 ,缺失率为 17.0 %。在良性与交界性上皮性卵巢肿瘤中未见FHIT蛋白缺失。在上皮性卵巢癌不同组织学分级中FHIT蛋白的缺失率分别为G10 / 6、G2 8.0 %、G331.8% ,低分化肿瘤FHIT蛋白缺失率显著高于高中分化肿瘤 (P <0 .0 5 ) ;在不同组织学类型中 ,FHIT蛋白缺失仅见于浆液性癌和透明细胞癌 ,缺失率分别为 2 5 .0 %和 1/ 3,在粘液性癌和子宫内膜样癌中未见FHIT蛋白缺失 ,但差异无显著性 (P >0 .0 5 ) ;FHIT蛋白缺失与淋巴结转移、残留癌灶大小及nm2 3 H1产物表达有明显相关性 ,与FIGO分期、有无腹水及P5 3蛋白表达无明显相关性。结论 :FHIT蛋白缺失是恶性上皮性卵巢肿瘤的特征 ,FHIT蛋白表达缺失在卵巢肿瘤的发生发展过程中有一定的作用 ,可能与上皮性卵巢癌的恶性进展及转移有关 相似文献
45.
目的:探讨卵巢子宫内膜样癌中增殖细胞核抗原(PCNA)的表达及其病理特征之间的关系。方法:应用免疫组织化学S-P法对56例卵巢子宫内膜样癌,30例在位子宫内膜的石蜡标本进行PCNA检测。结果:卵巢子宫内膜样癌PCNA阳性率为94.6%,明显高于在位子宫内膜阳性率46.7%(P<0.001),PCNA阳性指数评分和细胞分化程度及临床期别有关,高分化肿瘤的PCNA阳性指数评分低于中,低分化肿瘤(P<0.05),I/II期卵巢子宫内膜样癌PCNA阳性指数评分低于Ⅲ/Ⅳ期(P<0.01),经随访发现,存活组PCNA阳性指数评分低于死亡组评分。结论:PCNA的检测可作为估计卵巢子宫内膜样癌的预后指标。 相似文献
46.
47.
子宫内膜异位是指子宫腔正常位置以外的异位内膜组织为特征的良性病变,与在位子宫内膜相似,对性激素有反应性改变。1异位子宫内膜与在位子宫内膜的组织病理学比较正常在位子宫内膜由苗勒管衍生而来,连接输卵管黏膜和宫颈管黏膜。 相似文献
48.
49.
[目的]探讨预防气管切开术后痰液所致接触性皮炎的护理。[方法]对40例气管切开的病人按入住时间单双日进行分组,给予不同的护理措施。[结果]观察组接触性皮炎发生率为15%,对照组接触性皮炎的发生率为75%,两组比较差异有统计学意义(P〈0.01)。[结论]对气管切开术后病人,在治疗过程中必须采取有效的预防和治疗措施。 相似文献
50.