苯那普利治疗高血压病的疗效观察及其对血脂、血糖的影响

原发性高血压患者６８例，盐酸苯那普利１０～２０ｍｇ／ｄ，少数治疗１周后疗效未达理想标准者加用适量钙拮抗剂或β－受体阻滞剂，疗程４周，观察其对原发性高血压的治疗作用以及对血脂、血糖等与高血压有关的血液因子的影响。结果显示，治疗后血压显著下降（Ｐ＜０．０１），同时可改善原发性高血压患者的肝肾功能和胰岛素抗性，而对心率和血脂无不良影响。认为，与其它血管紧张素转换酶抑制剂类药物一样，盐酸苯那普利有其独到的优势，有着良好的应用前景。     

泌尿系曲菌病的诊断与治疗(附5例报告)

提高泌尿系曲菌病的诊治水平。方法对１９９３年以来诊治的５例泌尿系曲菌病患者临床资料进行分析。     

中药提取液体外抗肠道念珠菌的作用

目的:观察27种中药醇提液及5种中药提取油对肠道念珠菌(白念、热带、克柔氏)的体外抗菌活性.方法:采用试管药基法将27种中药醇提取液倍比稀释成浓度50-3.125 g/L.中药提取油倍比稀释成5-0.0097 mL/L,对肠道念珠菌进行MIC观察.结果:27种中药醇提取液中有6种(土槿皮、黄连、黄柏、五倍子、桂皮、丁香)MIC均值为1.56-3.25 g/L,4种(广藿香、川芎、菖蒲、蛇床子)MIC均值12.5 g/L,2种(五味子、小茴香)MIC均值50 g/L,对念珠菌有不同程度的抑制作用,其他15种中药醇提取液无抑制作用.5种中药提取油(桂皮油、藿香油、丁香油、小茴香油、五味子油)对念珠菌均有较强的抑制作用.结论:6种中药醇提取液及5种中药提取油对念珠菌(白念、热带、克柔氏)均有较强的抑制作用.     

五种抗深部真菌药物对烟曲霉体外抗菌活性的实验研究

目的 测定五种抗深部真菌药物对烟曲霉体外抗菌活性,为临床治疗侵袭性烟曲霉感染提供理论依据.方法 应用美国临床实验室标准化协会(CLSI)的微量液基稀释法 M38-A方案,测定烟曲霉临床株对伊曲康唑(ICZ)、两性霉素B(AmB)、伏立康唑(VRC)、卡泊芬净(CBF)、 氟康唑(FCZ)的敏感性.结果 MIC几何均数VRC为 0.29 μg/ml、CBF为0.45 μg /ml、ICZ为0.52 μg /ml、AmB为0.55 μg /ml、FCZ为62.58 μg /ml.结论 VRC、CBF、ICZ、AmB均有很强的抗烟曲霉作用,FCZ对烟曲霉均耐药.     

肉桂油对小鼠胃白念珠菌感染的治疗作用

目的: 探讨肉桂油治疗胃白念珠菌感染的可行性.方法: 制作胃白念珠菌感染小鼠120只, 随机分为4组, 每组30只. 肉桂油治疗组分3组, 每天给予1 mL 1.25、1.88、2.5 g/L肉桂油溶液灌胃, 对照组每天给予50 g/L葡萄糖溶液1 mL灌胃, 10 d后取小鼠胃组织行真菌镜检及组织病理检查, 发现白念珠菌菌丝为阳性.结果: 3个浓度的肉桂油治疗组的真菌镜检及组织病理检查阳性率均显著低于对照组(χ2 = 14.14, 6.97, 7.04;30.08, 25.36, 28.09, 均P<0.01), 肉桂油治疗组之间比较无差异(χ2 =2.04, 0.28, P>0.05).结论: 三种浓度肉桂油均可杀死小鼠胃内的白念珠菌, 肉桂油可用来治疗胃白念珠菌感染.     

药敏试验中丝状真菌定量接种的实验探索——菌丝生成法

真菌感染日益增多，抗真菌新药不断推出，耐药菌株也不断出现，真菌药敏试验亟需统一和推广。准确定量接种是获得可靠药敏试验结果的前提，而丝状真菌定量接种较为困难。本实验选用须癣毛癣菌就丝状真菌药敏试验定量接种问题作一探索。材料与方法１．菌种须癣毛癣菌（Ｔｍ）１株，为购于协和医科大学南京皮肤病研究所菌种保藏中心的标准株。２．药物特比萘芬（瑞士山德士制药厂生产）。蒸馏水溶解特比萘芬，将特比萘芬溶液加入新鲜制备沙堡琼脂培养基中，使其药物浓度为０．１ｕｇ／ｍｌ，首次稀释１０倍，再倍比稀释４次，高压灭菌，得浓度…     

伊曲康唑治疗生殖器念珠菌病36例

目的探讨伊曲康唑治疗生殖器念珠菌病的方法.方法口服伊曲康唑200 mg,1次/d,外用达克宁霜或洁尔阴,连用7天.结果治愈88.89 %(32/36),好转8.33 %(3/36),无效2.78 %(1/36),总有效率97.22 %(35/36).结论口服伊曲康唑外用达克宁霜或洁尔阴7日疗法,治疗生殖器念珠菌病疗程短,治愈率高.     

科玛嘉显色培养基检测深部念珠菌感染538例分析

目的 对科玛嘉念珠菌显色培养基在深部念珠菌标本检测中应用的评价。方法 对直接镜检阳性的538例患者的便、痰、尿标本，采用科玛嘉显色培养25℃ 48—72h，根据培养基表面菌落不同的颜色，鉴定念珠菌的种类。结果 538例深部标本，白念珠菌266株，热带念珠菌105株，光滑念珠菌77株，克柔氏念珠菌59株。结论 科玛嘉念珠菌显色培养基优于常规沙氏生化法，且快速、简便、准确地分离鉴定各种念珠菌，可做为检测深部念珠菌的首选方法。     

Mechanisms,clinically curative effects,and antifungal activities of cinnamon oil and pogostemon oil complex against three species of Candida

The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of the complexes against Candida using proportionally-diluted test-tube medium and examined the evolution of the morphology and structures of Candida albicans using scanning electronic microscopy(SEM) and transmission elec tronic microscopy(TEM).We found that the aver age MIC values of the complexes against the fung were 0.064 mg/mL(cinnamon oil),0.032 mg/mL(pogostemon oil) for Candida albicans,0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil for Candida tropicalis,and 0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil),for Candida krusei.SEM examination over a 24-48 h period showed that the morphology of Candida albicans cells changed significantly.Irregular hollows ap peared on the surfaces,inside organelles were destroyed and the cells burst after treatment.TEM examination over a 48-72 h period indicated that the cell walls were damaged,organelles were destroyed and most cytoplasms became empty bubbles.Sixty intestinal Candida-infected patients were treated with a capsule containing cinnamon and pogostemon oil.The curative ratio was 71.67%(43/60),and the improvement ratio was 28.33%(17/60),giving a to talratio of 100%.Thus,the cinnamonoil and pogostemon oil complexes had strong anti-funguseffectsag ainst Candida albicans,Candidatropicalis,and Candidakrusei.They impacted the morphology and sub-micro structures of the fungus within48-72h,and eventually denatured and killed the cells.The complexes have also shown considerable curative effects to intestinal Candida infections.