排序方式: 共有46条查询结果,搜索用时 15 毫秒
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目的探讨复方感冒冲剂体外对流感病毒(H3N2)的抑制作用,为临床合理用药提供科学依据。方法使用狗肾传代细胞(Madin-Darby canine kidney,MDCK)建立体外病毒感染模型。将病毒与药物通过三种不同给药方式,通过细胞病变法观察复方感冒冲剂对流感病毒的抑制及对被感染细胞的保护作用。结果复方感冒冲剂在感染病毒同时加药方式下对流感病毒(H3N2)感染的MDCK细胞有明显的保护作用;在先给药再感染病毒的方式下对MD-CK细胞的保护作用较弱;在先加病毒后加药的方式下,复方感冒冲剂对病毒感染的MDCK细胞无明显保护作用。结论复方感冒冲剂具有体外抗流感病毒作用,其药效发挥可能依赖机体的代谢并与给药方式有关。 相似文献
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目的 研究新城疫病毒(Newcastle disease virus,NDV)19417株体外对小细胞肺癌细胞NCI-H446及正常人胚肺成纤维细胞HFL-1的杀伤作用. 方法 应用四甲基偶氮唑盐比色法检测NDV D417株对NCI-H446和HFL-1的杀伤效应.D417株感染NCI-H446后,于光镜和电镜下检查细胞病理变化. 结果 NDV D417株对NCI-H446有杀伤作用,杀伤作用与病毒剂量和作用时间呈正相关.13417株对HFL-1也有杀伤作用,但比同等条件下对NCI-H446的杀伤作用弱.D417株感染NCI-H446后光镜下可见细胞病变及细胞融合现象,电镜下可见细胞呈凋亡形态. 结论 NDV D417株对小细胞肺癌细胞有较强的杀伤作用,对正常细胞影响较小. 相似文献
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6株NDV鄱阳株对肝癌细胞杀伤作用的初步研究 总被引:2,自引:0,他引:2
目的:研究从江西鄱阳湖野鸭分离的6株NDV对肝癌细胞的杀伤效应,进一步筛选NDV溶瘤毒株。方法:用MTT法研究6株NDV鄱阳株对两株传代肝癌细胞株Novikoff和HepG-2及一株正常肝细胞株HL-7702的杀伤效应。结果:6株NDV鄱阳株对肝癌细胞株Novikoff和HepG-2有显著杀伤效应,而对人正常肝细胞HL-7702无明显影响;病毒对细胞的杀伤活性与病毒作用剂量和病毒作用时间成正比;病毒在肝癌细胞中有明显复制增殖现象;Novikoff肝癌细胞对NDV敏感性强于HepG-2肝癌细胞。结论:6株NDV鄱阳株对Novikoff及HepG-2肝癌细胞产生显著的杀伤作用,而对正常肝细胞HL-7702未见明显影响。 相似文献
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Objective To study the anti-tumor effects of Newcastle disease virus (NDV) strain D817 on human colon carcinoma model in nude mice. Methods The nude mouse model of human colon carcinoma was established by subcutaneous inoculation of human colon cancer LOVO cells. The tumor-bearing mice were given PBS, 5-Fu, high-dose NDV D817, moderate-dese NDV D817 or low-dose NDV D817 via caudal vein injection. The tumor size and weight of mice were measured. The liver damages were examined by histopathology. Apoptosis and necrosis of tumor ceils were detected by flow cytometry. The endotumoral content of TNF-α was detected using a mouse TNF-a ELISA kit. The live vires was detected by bemagglutination (HA) test. Results The moderate-dose NDV D817 inhibited the tumor growth more apparently than 5-Fu. The tumor growth inhibition rate reached to 48.1%. The liver damage and the weight change caused by NDV were less severe. NDV D817 made an increased apoptosis index and induced production of TNF-α. Live virus was not detected in important organs except in the tumor of nude mice by HA test. Conclusion In the anti-tumor process in nude mice bearing xenografts of human colon carcinoma, a suitable dose of NDV D817 is more safe and effective. 相似文献
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新城疫病毒7793株对结肠癌小鼠肝转移的抑制效果及其可能的机制 总被引:1,自引:0,他引:1
目的:以脾脏保留法建立结肠癌小鼠肝转移模型,评价新城疫病毒(Newcastle disease virus,NDV)7793株对小鼠结肠癌肝转移的抑制效果,并初步探讨NDV抑瘤的免疫激活机制。方法:经脾注入1×107/ml小鼠结肠癌细胞CT26的单细胞悬液0.1 ml,建立结肠癌CT26小鼠肝脏转移瘤模型;建模小鼠随机分3组(每组20只): PBS阴性对照组、NDV7793给药组和5-FU给药组,于建模当天起连续5 d经腹腔分别注射PBS(0.1 ml/d)、NDV7793(512 HU/kg)和5-FU(20 mg/kg)。观察各组小鼠的生存状态,分析肝脏成瘤情况,计算抑瘤率和胸腺指数。ELISA法检测模型小鼠肝脏的IFN-γ水平。结果:成功构建小鼠结肠癌肝转移模型。NDV7793给药组小鼠未观察到明显的不良反应,生活状态好于PBS组和5-FU组。NDV7793组和5-FU组小鼠的肝转移瘤数量较PBS组均显著减少\[ (20.40±5.20) 、(205.50±19.21) vs (265.30±35.73)个,均 P <0.01\],NDV7793组的抑瘤率明显高于5-FU组(75.4% vs 48.0%, P <0.05),NDV7793组小鼠的肝脏癌灶范围小,癌细胞以坏死或凋亡为主。NDV7793组和5-FU组小鼠的中位生存期明显长于PBS阴性对照组(30、22 vs 17 d, P <0.01)。NDV7793组小鼠肝脏IFN-γ的表达和胸腺指数均显著高于5-FU组和PBS组(均 P <0.05)。结论:NDV7793株对结肠癌小鼠的肝转移具有较强的抑制效果,并可能通过上调肝脏的IFN-γ以及提升胸腺指数来抑制结肠癌的肝转移。 相似文献