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目的:初步探索生血散保护骨髓造血功能的作用机制。方法:采用大剂量CTX一次性腹腔注射法建立小鼠骨髓抑制模型,观察生血散对正常及模型小鼠骨髓CFU—GM形成率和骨髓造血组织容量的影响。结果:生血散对正常小鼠CFU—GM形成率和骨髓造血组织容量均有上调作用,同时对CTX所致小鼠CFU—GM生成抑制有明显保护和缓解作用,并能显著提高模型鼠骨髓造血组织容量。结论:生血散的作用机理在于对骨髓造血干细胞的保护和刺激作用。 相似文献
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[目的]观察升血灵胶囊联合抗淋巴细胞球蛋白/抗胸腺细胞球蛋白和环胞菌素A治疗重型再生障碍性贫血的临床疗效。[方法]收集我院治疗的重型再生障碍性贫血60例,其中升血灵胶囊联合ALG/ATG和CSA治疗27例为治疗组,以ALG/ATG+CSA治疗33例为对照组.比较患者治疗前后血常规,骨髓象,造血干/祖细胞生长等指标。[结果]治疗组有效率77.8%,对照组有效率66.7%.两组疗效无明显差异(P〉0.05)。治疗组在减轻临床症状,改善生活质量等方面优于对照组。[结论]升血灵胶囊能缩短ALG/ATG+CSA治疗重型再生障碍性贫血的反应时间,为治疗重型再生障碍性贫血的有效中成药。 相似文献
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目的:探讨糖皮质激素受体(glucocorticoidreceptor,GR)、雄激素受体(androgenreceptor,AR)表达对再生障碍性贫血(aplasticanemia,AA)影响。方法:利用酶联免疫吸附试验(ELISA)法检测急性再生障碍性贫血(acuteaplasticanemia,AAA)、慢性再生障碍性贫血(chronicaplasticanemia,CAA)以及对照组的外周血单个核细胞胞浆和胞核内AR、GR阳性表达水平。结果:与对照组相比,AAA组、CAA组的AR、GR显著低于对照组(P〈0.05);AAA组与CAA组相比,AAA组AR、GR阳性水平显著高于CAA组(P〈0.05)。结论:AA患者的AR、GR表达水平下降,提示AA的发病与受体水平密切相关。 相似文献
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Objective: To explore differences in bone marrow angiogenesis seen in aplastic anemia (AA) patients presenting with differential Chinese medicine (CM) syndrome, and to correlate these differences with clinical pathology. Methods: Thirty-five patients were enrolled, including 18 with "yang deficiency syndrome" and 17 with "yin deficiency syndrome." Bone marrow biopsies and serum were collected. Microvessel density (MVD) and positive expression of vascular endothelial-derived growth factor (VEGF) were detected by immunohistochemisty. Hypoxia inducible factor -α (HIF-α ), and VEGF expression were assayed by enzyme-linked immunoabsorbent assay (ELISA), serum lactate dehydrogenase (LDH) was tested by enzyme method and liquid chip technology was used to detected the expression of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-'y and tumor necrosis factor (TNF)-α. Results: Counts for leukocytes, absolute neutrophils and platelets in "yin deficiency syndrome" were lower than those found in "yang deficiency syndrome" (P〈0.05). MVD and VEGF expression, and the positive rate of CD34 and VEGF in bone marrow were lower in hA, especially in "yin deficiency syndrome" (P〈0.01 or P〈0.05). "Yin deficiency syndrome" displayed decreased VEGF and LDH expression, and enhanced expression of HIF-α as compared to "yang deficiency syndrome" (P〈0.05). Levels of IL-4 and IL-6 were higher in AA (P〈0.01), but IL-10 was decreased (P〈0.05). High TNF-c~ expression was seen in "yang deficiency syndrome" and IFN- γ expression was decreased in "yin deficiency syndrome" as compared with normals (P〈0.01 and P〈0.05, respectively). Conclusion: AA patients have lower MVD than normals, especially in "yin deficiency syndrome." MVD might differentially correlate to disease severity, and could be dependent on bone marrow or serum VEGF expression and LDH. Additionally, IL-2, IL-10, IL-4 and IFN- γ were negatively associated while IL-6 and TNF- α were positively associated with MVD. 相似文献
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目的:观察达那唑、阿赛松联合中药参血胶囊治疗难治免疫性血小板减少症的疗效对其机制进行探讨。方法:65例入组患者分为达那唑联合阿赛松治疗组与达那唑联合阿赛松及参血胶囊治疗组分别进行统计。达那唑、阿赛松治疗组:达那唑5mg/(kg.d)(0.2-0.4/d)、阿赛松0.5mg/(kg.d)(24mg-36mg/d); 达那唑、阿赛松联合参血胶囊组:达那唑、阿赛松用法同上,同时再给予中药参血胶囊1.4/d,分2次口服; 两组治疗观察时间均为4个月,检测各组患者治疗前后CD4+CD25+细胞和CD4+CD25+Foxp3+细胞的表达水平。结果:达那唑联合阿赛松治疗组有效率31.2%,达那唑联合阿赛松及参血胶囊治疗组有效率57.6%。两组差异有显著统计学意义(相似文献