正交实验法优选复方三七胶囊的提取工艺

目的：优选复方三七胶囊的提取工艺。方法：采用L9（3^4）正交试验,以人参皂苷Rg1转移率和出固率为指标,考察提取用醇浓度、加醇量、提取时间对提取效果的影响。结果：最佳工艺为药材加70％乙醇,提取两次,第一次用8倍量,第二次用7倍量,每次提取1小时。结论：本法为复方三七胶囊醇提工艺的确定提供实验依据。     

电针结合星状神经节阻滞治疗椎动脉型颈椎病

目的:观察电针结合合星状神经节阻滞治疗椎动脉型颈椎病患者的临床疗效。方法:120例椎动脉型颈椎病患者随机分为3组,电针组40例用电针刺激体穴结合C3-5夹脊穴治疗;阻滞组40例采用利多卡因注射液5ml及0.9%生理盐水5ml的混合液星状神经节阻滞治疗;综合组40例则结合2种方法综合治疗。治疗前后以临床症状评分量表评定疗效。结果:治疗2周后临床症状积分,综合组明显低于电针组和阻滞组(P<0.05),治愈率和总有效率高于电针组和阻滞组(P<0.05,0.01)。结论:电针配合星状神经节阻滞治疗椎动脉型颈椎病能明显改善患者临床症状,提高治疗效果。     

杂色蛤核苷部位的保肝作用研究

目的研究杂色蛤核苷类部位在体内、体外的保肝作用。方法采用CCK-8法测定核苷对细胞存活率的影响,四氯化碳(CCl_4)诱导肝细胞损伤和过氧化氢(H_2O_2)诱导肝细胞损伤的体外实验以及CCl_4诱导急性化学性肝损伤模型和D-半乳糖致衰老抗氧化模型的体内实验来测定谷丙转氨酶(ALT)、谷草转氨酶(AST)、超氧化物歧化酶(SOD)、丙二醛(MDA)、还原性谷胱甘肽(GSH-Px)来评价杂色蛤核苷部位的保肝作用。结果杂色蛤核苷部位可显著提高肝细胞的存活率,显著降低肝损伤的ALT、AST水平,显著升高SOD的活性,降低MDA的含量(P0.05~0.01)。结论杂色蛤核苷部位可保护CCl_4诱导的小鼠化学性肝损伤,对抗D-半乳糖致小鼠衰老,在体外对CCl_4、H_2O_2诱导的肝细胞均有显著的保护作用,为开发和利用杂色蛤资源,研制保肝产品提供了实验依据。     

Clinical observation on electroacupuncture plus <Emphasis Type="Italic">Jiawei Jinhuanggao</Emphasis> (Supplemented Golden Yellow Paste) for gouty arthritis

Objective

To observe the clinical effect of electroacupuncture (EA) plus self-made Jiawei Jinhuanggao (Supplemented Golden Yellow Paste) for gouty arthritis.

Methods

A total of 80 cases with gouty arthritis were randomly allocated into an observation group (n=40) and a Western medication group (n=40). Cases in the observation group received EA and external application of self-made Jiawei Jinhuanggao (Supplemented Golden Yellow Paste), whereas cases in the Western medication group took Colchicine and Allopurinol tablets orally. After 10 d of treatment, the pain, joint swelling and uric acid in blood were observed. In addition, the follow-up was conducted 6 months after end of the treatment to evaluate the long-term effect.

Results

After treatment, there were no between-group statistical differences in pain and uric acid in blood (P>0.05); and there were between-group statistical differences in joint swelling and relapse rate (P<0.05). The total effective rate was 97.5% in the observation group, versus 95.0% in the Western medication group, showing no statistical difference (P>0.05).

Conclusion

EA plus Jiawei Jinhuanggao (Supplemented Golden Yellow Paste) has safe and long-term efficacy for gouty arthritis efficacy.

     

中西医结合综合治疗肺心病急性期122例

目的 现察肺心痛急性发作期中西医结合综合治疗方案的临床疗效.方法 将122例肺心病急性发作期患者随机分为2组,治疗组采用中西医结合综合方案(西医常规化治疗基础上,辨证分型为痰湿壅肺证者给予基础方:三拗汤十瓜蒌薤白半夏汤十桔梗汤;肺脾两虚型者在基础方上加香砂六君子;阳虚水泛型在基础方上加苓桂术甘汤)治疗,对照组采用西医常规化治疗.2组均治疗14d.观察2组患者综合疗效评定、主要症状、体征、血气分析结果、基于患者报告的结局评价(PRO)的差异.结果 治疗组在综合疗效评定、主要症状、体征、血气分析结果、基于患者报告的结局评价(PRO)等方面均优于对照组,差异有统计学意义(P＜0.05).结论 肺心痛急性发作期采用中西医结合治疗方案能提高总体疗效,改善症状、体征、血气分析结果,提高生活质量.