慢性前列腺炎患者在庆大霉素治疗中前列腺液及精液中的浓度

急、慢性男性生殖系统的感染在临床上较常见,其中慢性前列腺炎是发生反复尿路感染的重要原因,而在治疗上却是一个棘手的问题。抗生素在慢性前列腺炎的治疗中有一定的地位,Stamey等进行动物实验对十五种药物(包括抗生素、磺胺药及萘啶酸等)进行了前列腺液及血浆中的浓度测定。但未见有庆大霉素的报道。目前关于抗生素在人类前列腺液及精液中分布情况的文献极少。     

成人及儿童无症状菌尿的调查

无症状菌尿是一种隐匿性的尿路感染,完全没有尿路感染的症状,发生在健康人群中。但是对人体有潜在性危害,特别是对儿童、妊娠妇女及老年人影响尤其重大。尽早发现和治疗可避免许多后患。为了解无症状菌尿在现阶段的发病情况,我们从1980年5月～1983年6月在学龄前儿童、中老年科技人员和干部体检中进行了此项调查,现总结并结合文献讨论如下:     

儿茶酚胺增多症9例临床分析

嗜铬细胞瘤和肾上腺髓质增生临床表现与实验室检查基本相似。肾上腺髓质与皮质一样,其功能亢进同样可由增生与肿瘤引起,因而可把单纯性肾上腺髓质增生与嗜铬细胞瘤二者总称为儿茶酚胺增多症。我院自1977年～1984年共收治儿茶酚胺增多症9例,给手术病理证实1例为肾上腺髓质增生,8例为嗜铬细胞瘤。临床分析如下。 临床资料 一、9例病人中男性3例,女性6例,男女之比为1:2。 二、肿瘤发生于肾上腺部位5例,右侧人     

复方丹参注射液改善大鼠内毒素休克血液流变学

目的 探讨复方丹参注射液对内毒素休克血液流变学的影响。方法 ＳＤ大鼠随机分成４组：空白对照组（Ⅰ组）,内毒素休克组（Ⅱ）及按每千克体重注射４ｇ和８ｇ复方丹参注射液防治组（Ⅲ组和Ⅳ组）,静注大肠杆菌内毒素后４ｈ,取血行血液流变学检测,并观察复方丹参注射液对检测结果的影响。结果 内毒素休克时,全血粘度（ηｂ）、血浆粘度（ηＰ）,红细胞聚集指数（ＥＡＩ）和红细胞刚性指数（ＥＲＩ）明显升高;Ⅳ组上述指标均     

曲尼司特对环孢素A诱导的人肾小管上皮细胞向间充质转变的抑制作用

Objective To study the effect of tranilast on cyclosporine A (CsA)-induced epithelial-to-mesenchymal transition in human renal tubular epithelial cells, and investigate the mechanism of its antifibrotic effect. Methods Cultured HK-2 cells were divided into four groups: (1)In the control group, cells were treated without any medicine; (2) The cell were treated with CsA (4. 2μmol/L) for 72 h; (3) The cells were treated with a combination of CsA (4. 2 μmol/L) and tranilast (100μmol/L); (4) The cells were treated with tranilast (100 μmol/L) alone for 72 h.Morphological changes of the cells were assessed by phase-contrast microscopy. The immunofluorescence and Western blotting were adopted to detect the expression of E-cadherin, α-SMA and OPN mRNA and proteins respectively. Results Tranilast could markedly ameliorate the morphological changes of HK-2 cells stimulated by CsA. The irmmunofluorescence staining revealed the expression of E-cadherin was markedly decreased in HK-2 cells stimulated with CsA for 72 as compared with the control group, while the expression of α-SMA and OPN was significantly higher in CsA group than the control group. The expression of E-cadherin in the CsA + Tranilast group was higher than the CsA group, while the expression of α-SMA and OPN in the CsA + Tranilast group was lower than the CsA group. Western blotting showed that protein expression level of E-cadherin in CsA group was dramatically lower than that in the control group (P＜0. 05), while that of α-SMA and OPN in CsA group was significantly higher than in the control group (P＜0.05). The protein expression level of E-cadherin in HK-2 cells in the CsA + Tranilast group was markedly higher than in the CsA group (P＜0.05), and that of α-SMA and OPN in CsA + Tranilast group was significantly lower than in the CsA group (P＜0. 05). Conclusion Tranilast can block the CsA-induced epithelialto-mesenchymal transition in HK-2 cells probably by suppressing the expression of OPN.     

巨大成人型肾母细胞瘤3例报告并文献复习

目的探讨巨大型成人肾母细胞瘤的诊断和治疗方法,提高该病的诊断率与治愈率。方法回顾性分析南京医科大学第一附属医院2007至2008年间收治的3例巨大成人肾母细胞瘤的临床表现、分期、治疗及预后。结果 3例患者按照美国国家肾母细胞瘤研究组分期：Ⅱ期2例,Ⅲ期1例。3例均行根治性肾切除术,术后辅以放疗和化疗。所有病例均获得随访,随访2～3年,3例均生存。结论成人肾母细胞瘤是一种比较少见的恶性肿瘤,早期诊断、手术治疗、辅以放疗和化疗等可明显提高治愈率并改善其预后。     

原位回肠新膀胱手术的临床研究

目的:探讨全膀胱切除原位回肠代膀胱术治疗浸润性膀胱肿瘤的临床疗效及术后并发症的预防?方法:回顾性分析南京医科大学第一附属医院泌尿外科2005年1月~2008年3月21例膀胱肿瘤行全膀胱切除原位回肠代膀胱术的临床资料?结果:所有病人均得到满意随访,本组患者除2例外均无瘤存活?手术时间为 5.5~7.5 h,平均5.9 h;术中出血量为150~1 200 ml,平均为 450 ml;所有患者术后均能自控排尿,无上尿路积水,代膀胱残余尿量20~80 ml,功能状态良好?结论:全膀胱切除原位回肠代膀胱术具有术后代膀胱容量大?内压低?可控性能好等优点,是一种较理想膀胱全切术后的膀胱替代术式?     

输尿管内支架引流减少肾移植术后并发症104例分析

肾移植术后出现尿瘘或吻合口狭窄、梗阻是肾移植后严重的手术并发症。利用特殊类型的双“Ｊ”管作为肾移植病人的内引流支架，对减少和预防肾移植术后尿路并发症，提高围手术期安全度，促进病人恢复，均取得较好的临床效果。我院自１９９５年１０月至１９９８年１２月期间...