糖尿病低镁血症

于111名糖尿病患者中测血清镁、红细胞镁与尿镁,以探讨糖尿病低镁血症的发生率和发生机理。发现糖尿病患者平均血清镁与红细胞镁浓度显著低于正常对照组而24小时尿镁则显著高于正常对照组。血清镁浓度与红细胞镁浓度呈正相关,与尿镁呈负相关,并与胰岛素面积和胰岛素面积/血糖面积呈正相关。10例用胰岛素治疗的糖尿病患者平均血清镁浓度显著     

HYPOMAGNESEMIA AND HEART COMPLICATIONS IN DIABETES MELLITUS

In order to establish the relationship between hypomagnesemia and heart complications in diabetes mellitus, the magnesium levels of serum, erythrocytes, and urine in 109 diabetics and 130 normal controls were studied. It was found that serum and erythrocyte magnesium levels were significantly lower, and urine magnesium significantly higher in the diabetics than in the controls. Serum magnesium in diabetics with heart complications (n=17) was significantly lower than that in diabetics without heart complications (n=92). The results obtained by mulltiple regression analysis suggested that hypomagnesemia, hypertension, and body mass index contribute to the occurrence of heart complications in diabetics. It was believed that hypomagnesemia may be one of the risk factors for heart complica- tions in diabetes mellitus.     

NIDDM患者白细胞变形能力与糖尿病微血管病变的关系

测定80例NIDDM患者的WCD,结果显示其降低与尿AER水平增高和糖尿病视网膜病变严重程度呈显著相关性,且同时并发上述两种病变组的WCD显著低于仅有白蛋白尿或糖尿病视网膜病变组,而后者WCD又显著低于无上述病变组。提示糖尿病患者WCD降低可能在糖尿病微血管并发症的发生与发展中是一重要的环节。     

糖尿病患者心脏自主神经功能改变及其相关分析

目的 探讨糖尿病患者心脏自主神经功能的改变及其相关分析。方法 采用心率功率谱分析测定70例糖尿病患者心脏自主神经功能,并检测空腹血糖,糖化血红蛋白(GHbA_1c)和尿白蛋白排泄率(AER)等。结果 糖尿病患者心脏交感神经活性(SA),副交感神经活性(PA)明显低于正常对照组,且糖尿病患者中AER增高组SA,PA明显低于AER正常组;糖尿病患者SA,PA均与年龄、空腹血糖、GHbA_1和AER呈显著负相关。结论 糖尿病患者SA,PA减退,且与年龄增高,代谢控制不良和AER增高有密切关系。     

糖尿病结膜微血管病变与血清镁和血脂的关系

本文报道62例非胰岛素依赖型糖尿病患者血清镁、血脂与糖尿病结膜微血管病变的关系。与无结膜微血管病变者比较,有结膜微血管病变者(13例)血清镁和高密度脂蛋白胆固醇水平显著降低,而血清低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值显著升高,提示低镁血症和高密度脂蛋白胆固醇降低可能是糖尿病病人发生微血管病变的危险因素之一。     

席汉氏病危象的误诊〔附104例分析〕

席汉氏病危象是席汉氏病的严重并发症，若不及时诊治，常危及病人生命。我院1958年5月—1984年5月收治席汉氏病患者104例，，发生危象者24例，占23％，由于其临床表现复杂多变，常可以误诊。本文就我院10例席汉氏病危象的误诊作一分析，以供参考。     

肺心病患者肾功能观察

严重肺心病患者合并肾功能衰竭并不少见。在肺心病并发症中居第四位,仅次于肺性脑病、消化道出血和感染性休克。但在轻型肺心病患者中,是否累及肾脏则缺乏了解。本文对15例缓解期轻、中型肺心病患者用放射性肾图、酚红排泌试验与13小时尿浓缩后渗透压测定等检查方法,观察肾功能改变,结果如下。方法及结果一、15例缓解期肺心病人中。轻型14例、中型1例(按1977年全国肺心病统一诊断标准和分期分级标准),均进行了酚红排泌试验、放射性同位素肾图检查。 16例患者酚红排泌试验,2小时排泌率都在     

糖尿病大鼠视网膜血管蛋白激酶C同工酶表达模式

目的 :探讨糖尿病大鼠视网膜血管蛋白激酶C(PKC)活性变化及其同工酶表达特性。方法 :采用渗透休克法获取正常及链脲佐菌素诱导的糖尿病大鼠视网膜血管。原位PKC催化活性分析法测定两组大鼠视网膜血管PKC活性 ,α、β、γ、δ、ε、ζ-PKC同工酶表达水平则采用Westernblot法。结果 :病程 2月时糖尿病大鼠视网膜血管PKC活性为 346± 18.1PmolesPimin-1·mgprotein-1(单位下同 )较正常对照组 131± 10 .5显著为高 (P <0 .0 5 )。α、β、δ、ζ -PKC分布于正常和糖尿病大鼠血管细胞浆、膜部 ,而γ、ε则无信号 ,α、β、ζ同工酶在糖尿病大鼠视网膜血管膜部较正常对照大鼠显著为高 (P <0 .0 5 ) ,尤以α、β为著 ,光密度 (OD)值分别为对照的 2 82 %± 32 %、340 %± 2 6 %、187%± 14 %。而糖尿病大鼠视网膜血管浆部α、β、ζ -PKC同工酶表达则较对照组显著为低 (P <0 .0 5 ) ,其OD值分别为对照的 71%± 11%、6 3%± 8%、84 %± 6 %。但δ -PKC浆部则较对照组显著增高 ,其OD值为正常对照之 2 0 8%± 13% ,但膜部δ -PKC与正常对照相比较无显著性差异。结论 :糖尿病视网膜病变 (DR)靶组织———视网膜血管中PKC显著激活 ,呈α、β、ζ同工酶从胞浆至胞膜 ,而δ -PKC则从胞膜至胞浆移位激活特征。     

抗坏血酸对糖尿病大鼠肾脏PKC-β1活化的影响

目的：探讨抗坏血酸对糖尿病大鼠肾脏蛋白激酶C—βl(PKC—β1)活化的影响e方法：Wistar大鼠随机分为3组，正常对照组、糖尿病组和糖尿病治疗组。实验第9周测定血浆和肾脏抗坏血酸水平，免疫荧光检测和激光共聚焦显微镜观察PKC—βl活化水平：结果：与正常对照组相比，糖尿病组血浆、肾脏抗坏血酸水平显著降低(P＜0.05)；肾脏PKC—β1活化水平显著增加(P＞0.05)；糖尿病治疗组8周后血浆、肾脏抗坏血酸水平明显增高，肾脏PKC—β1活化水平显著下降，与正常对照组相比差异无显著性(P＞0．05)。结论：糖尿病时肾脏PKC—βl活化增加可能与体内抗坏血酸水平降低有关，补充抗坏血酸可抑制糖尿病大鼠肾脏PKC—β1活化。     

INDIRECT FLUORESCENCE ANTIBODY TES''T IN DIAGNOSIS OF IDIOPATHIC ADDISON''S DISEASE

By using indirect immunofluorescence antibody test, we detected adrenal, thyroid and antinuclear antibo;dies in 40 patients with Addison's disease and 91 patients with other endocrinopathies. In 25 patients with idiopathic Addison's disease antiadrenal autoantibody (AA) was found to be positive in 68To, whereas in 15 patients with tuberculous Addison's disease it was positive in 13%. There was significant difference between the two. In 91 patients with other endocrinopathies, AA was positive in only l.10lo. The antibody detected in all the positive cases was IgG. AA positivity in patients with idiopathic Addison's disease was unrelated to agc, sex, duration o;f disease and treatment. In patients with idiopathic Addison's disease the titcr of thyroid and antinuclear antibodies was significantly higher than that in those with tuberculous Addison's disease, particularly in the female. We believe that positive AA in some degree is l_elpful in the diagnosis of idiopathic Addison's disease, particularly in suspected cases. Besides, in patients with Addison's disease but no evidence of tuberculosis positive AA indicates that anti tuberculous therapy might not be used as conven- tionarlly.