超声乳化吸除术治疗Fuchs综合征并发白内障的疗效

目的:探讨超声乳化吸除术治疗Fuchs综合征并发白内障的临床效果.方法:分析在我院行超声乳化吸除术的Fuchs综合征并发白内障患者18例18眼,术中观察并发症的情况,术前及术后测量视力、眼压、角膜内皮细胞密度,术后观察眼内炎症反应程度、并发症等情况.结果:平均随访时间为9.8±3.3mo.术中唯一的并发症为周边虹膜出血(17%).最佳矫正视力(LogMAR)术前为0.98±0.85,术后6mo为0.08±0.14,差异具有统计学意义(P<0.001).眼压术前为15.11±2.63mmHg,术后有2眼一过性高眼压,术后6mo为14.94±2.49mmHg,与术前相比,差异无统计学意义(P>0.05).术后角膜内皮细胞丢失率为10%±6%.术后2眼出现轻度的瞳孔区纤维素样渗出,1眼囊袋收缩综合征以及4眼后发性白内障.结论:超声乳化吸除术治疗Fuchs综合征并发白内障安全有效、并发症少.     

准分子激光上皮下角膜磨镶术研究的进展

准分子激光上皮下角膜磨镶术是一种表面角膜切削术,适合于大部分行准分子激光治疗屈光不正的患者,尤其对特殊的患者更有优势,其手术疗效与准分子激光原位角膜磨镶术类似.它可以避免角膜瓣相关的并发症和减少术后发生角膜扩张的危险,但是会引起术后疼痛和角膜上皮下混浊等并发症.为了探讨准分子激光上皮下角膜磨镶术的相关问题,现对该手术患者的术前评估、适应证、疗效和并发症等相关情况等作一综述.     

准分子激光原位角膜磨镶术的并发症

准分子激光原位角膜磨镶术是目前最常见的一种角膜屈光手术,但是它仍然存在并发症,如角膜瓣相关并发症、准分子激光消融的并发症、弥漫性角膜炎、感染性角膜炎、角膜瓣下上皮植入、干眼、医源性圆锥角膜及视网膜病变等,只有尽早作出诊断并进行相关处理,才能提高手术成功率.     

Rac1通过调控JAK2/STAT1信号通路参与神经炎症

目的 研究BV2小胶质细胞上Ras相关C3肉毒菌素物底物1(ras-related C3 botulinum toxin,Rac1)参与神经炎症的作用.方法 采用脂多糖(lipopcly saccharide,LPS)诱导BV2小胶质细胞,加入Rac1抑制剂EHT1864,用MTT法检测细胞活力;G-LISA和免疫荧光...     

近视屈光手术人群角膜非球面特性及其相关因素分析

目的 研究近视屈光手术人群眼角膜非球面特性(Q值)的分布特征以及相关因素对Q值的影响.方法 随机收集近视屈光手术患者300例(600眼),使用Orbscan Ⅱz眼前节分析系统K&Q计算软件获得眼角膜6 mm分析区域的Q值,并针对Q值的分布特征及其与相关的屈光度、角膜曲率和角膜直径等因素进行相关分析.结果 300例600眼角膜Q值分布范围-0.51～1.03,平均(-0.16±0.15).Q值与角膜曲率、模拟角膜镜读数、5 mm区不规则指数和角膜前表面Diff值之间呈负相关,与前房深度和角膜直径呈正相关,而与球镜度数、等效球镜度、柱镜度数、3 mm区不规则指数、角膜后表面Diff值、年龄、眼压和角膜厚度之间不相关.同一个体双眼的Q值差异无统计学意义,但是男女之间的Q值差异有统计学意义.结论 近视屈光手术人群眼角膜Q值呈近似正态分布,角膜Q值不是一个独立的参数,与眼部多个因素相关. Abstract： Objective To study the distribution characters of corneal asphericity (Q-value) in myopia population for corneal laser refractive surgery and the related influencing factors.Methods Six hundred eyes of 300 patients with myopia for corneal laser refractive surgery were enrolled in this study with each patient selected randomly. The K&Q calculator of Orbscan Ⅱz anterior segment system was used to obtain the Q-value of 6 mm optical zone in 300 cases (600 eyes),and statistical analysis was used to comprehend the distribution characters of Q-value and its relations with diopter,cornea curvature and cornea diameter and so on. Results The Q-value of 600 eyes ranged from -0.51-1.03 with the mean value -0.16±0.15.The Q-value showed a negative correlation with cornea curvature, simulated keratometry, irregular index of 5 mm zone, diff value of anterior surface and a positive correlation with anterior chamber depth and cornea diameter, but no relate with spherical diopter,spherical equivalent,astigmatism diopter, irregular index of 3 mm zone, diff value of posterior surface,age, intraocular pressure, cornea thickness. There was no significant difference between right and left eyes individually,but significant differences between men and women.Conclusions The Q-value of 600 eyes of 300 cases are approximately normal distribution.The Q value is not an absolute parameter,it is related with many factors.     

PLGA纳米粒抗肿瘤药物载体的研究进展

目的：阐述近年来PLGA 纳米粒作为抗肿瘤药物载体的研究进展。方法归纳国内外最新的文献报道,对PLGA纳米粒作为抗肿瘤药物载体在主动与被动靶向方面的应用研究进展进行综述。结果由于纳米材料可以增强抗肿瘤药物的靶向作用,而PLGA是经FDA认证的具有生物降解性及生物相容性的功能高分子有机聚合物,已经被广泛地应用于抗肿瘤药物的载体研究。结论 PLGA纳米粒作为抗肿瘤药物载体具有广阔的应用前景。     

Study on the RFLPs and amplication and rearrangement of the transforming genes in primary hepatic carcinoma,gastric carcinoma and brain tumor with six human oncogene probes

By using c-Ha-ras-1, N-ras Wigler (left sequence) and P52C.(right sequence), c-sis, v-erbB, c-myc and v-fos oncogenes as probes, restriction fragment length polymorphisms (RFLPs) of tumor tissue DNAs of 95 patients with gastric carcinoma, primary hepatic carcinoma and brain tumor, and those of 90 normal individuals were studied with the techniques of Southern blot and dot blot. Gene amplification and recombination were also examined in some tumors simultaneously. Some alleles of oncogene are reported in Chinese population for the first time. Moreover, the characteristic frequency of some "rare" alleles and genotypes occurred in some tumor samples is significantly higher than that occured in normal individuals. Pedigree analysis for 2 patients showed that some "rare" alleles are also abandant. Besides, gene amplification and recombination were found in some tumors.