A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia

Objective

To identify whether sarsasapogenin, a sapogenin from the Chinese medicinal herb Anemarrhena Asphodeloides Bunge, would augment the efficacy of risperidone and significantly improve cognitive functions in patients with negative symptoms dominated schizophrenia.

Methods

The trial was a double-blind, placebo-controlled, parallel-group design. The eligible patients were randomized into 2 treatment groups: sarsasapogenin group (sarsasapogenin plus risperidone for 8 weeks, n = 41) and placebo group (risperidone only for 8 weeks, n = 39). At the baseline, as well as at weeks 2, 4 and 8 of treatment, the therapeutic response was measured by using scales including Positive and Negative Symptoms Scale (PANSS), Wechsler Memory Scale (WMS), modified Chinese Wechsler Adult Intelligence Scale (mWAIS), Clinical Global Impression (CGI) and Brief Psychiatry Rating Scale (BPRS). The study period for each subject was 8 weeks and duration of overall trial was 2 years.

Results

Patients treated with sarsasapogenin plus risperidone demonstrated no statistically significant differences in changes in PANSS, WMS or mWAIS score at the end-point of the trial compared with patients treated with placebo plus risperidone. The incidence of treatment-emergent adverse events in patients treated with sarsasapogenin was not different from that observed in placebo group.

Conclusion

Sarsasapogenin did not augment the efficacy of risperidone in treating negative symptoms dominated schizophrenia. Sarsasapogenin at a dosage of 200 mg per day added to a flexible dosage of risperidone at 2–4 mg per day is safe and well tolerated by patients with negative symptoms dominated schizophrenia.     

安全文化在医院保卫工作中的推广与实践

1安全文化"安全文化"的概念产生于20世纪80年代的美国。1986年国际核安全检查组(INSAG)认为安全文化是存在于单位和个人中的素质和态度的总和,是种超越一切之上的观念[1]。国际健康安全委员会(HSCASNI)认为安全文化是个人和集体的价值观、态度、能力和行为方式的综合产物,决定于健康安全     

强制隔离戒毒人员心理健康状况分析

目的:了解强制隔离戒毒人员的心理健康状况,及不同强戒次数对其心理健康状况的影响。方法:对80例强制隔离戒毒人员进行SCL-90评定,评定分值与全国常模进行对照分析,用SPSS11.5社会统计软件进行统计。结果:强制隔离戒毒人员SCL-90评定结果总分、躯体化、强迫、人际关系、抑郁、焦虑、敌对、恐怖、偏执、精神病性与常模比较差异有显著性,P<0.01;接受强制戒毒3次及以上人员的心理健康状况明显差于初次强制戒毒人员,两者在总分、强迫症状、抑郁、焦虑、敌对、精神病性及其他等因子上比较,差异有显著性(P<0.05)。结论:强制隔离戒毒人员进入强制隔离戒毒所后,有较突出的心理健康问题,尤以抑郁、强迫、躯体化因子为著;强戒次数对强戒人员的心理健康状况有着明显的影响。     

晚发型抑郁障碍与轻度认知功能损害患者的认知功能差异研究

目的 探讨晚发型抑郁障碍患者与轻度认知功能损害患者的认知功能损害的差异.方法 研究对象为2012年7月～2013年8月上海市精神卫生中心老年科住院与门诊就诊符合DSM—Ⅳ诊断标准且起病年龄≥60岁的抑郁障碍患者,共26例为晚发型抑郁障碍组（LOD组）,另选择26例轻度认知功能损害的患者（MCI组）与26例正常老年人（NC组）.认知功能评估采用简明精神状态量表（MMSE）、蒙特利尔量表（MoCA）.结果 MMSE总分、MMSE分测验中计算力与注意力及MoCA总分、MoCA分测验中连线、注意、持续注意、计算、复述、延迟回忆在LOD组与MCI组差比较异无统计学意义（P＞0.05）,两组与NC组比较差异有统计学意义（P＜0.05）.三组在MMSE分测验的时间定向、延迟回忆、三步指令、书写书面指令及MoCA分测验的复制图、画钟、命名比较,MCI组均值最低,与NC组比较差异有统计学意义（P＜0.05）,与LOD组比较差异无统计学意义（P＞0.05）.结论 LOD组认知功能在注意力、延迟回忆、连线测验方面与MCI组损害程度相当.MCI组认知功能受损范围较LOD组广泛.